Organic Chemistry Of Drug Degradation
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Organic Chemistry of Drug Degradation
Author | : Min Li |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 306 |
Release | : 2015-10-20 |
Genre | : Medical |
ISBN | : 9781782625636 |
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The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.
Drug Stability and Chemical Kinetics
Author | : Muhammad Sajid Hamid Akash,Kanwal Rehman |
Publsiher | : Springer Nature |
Total Pages | : 284 |
Release | : 2020-11-01 |
Genre | : Medical |
ISBN | : 9789811564260 |
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This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics.
Stability of Drugs and Dosage Forms
Author | : Sumie Yoshioka,Valentino J. Stella |
Publsiher | : Springer Science & Business Media |
Total Pages | : 270 |
Release | : 2007-05-08 |
Genre | : Medical |
ISBN | : 9780306468292 |
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Drug products are complex mixtures of drugs and excipients and, as such, their chemical and physical stability kinetics are complex. This book discusses the stability of these dosage forms with preformulation studies through to the studies on the final products. The book is intended for graduate students, researchers and professionals in the field of Pharmaceutics and Pharmaceutical Chemistry.
Compendium of Drug Degradation
![Compendium of Drug Degradation](https://youbookinc.com/wp-content/uploads/2024/06/cover.jpg)
Author | : Min Li |
Publsiher | : Wiley |
Total Pages | : 600 |
Release | : 2022-12-05 |
Genre | : Science |
ISBN | : 1118832930 |
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The Organic Chemistry of Drug Design and Drug Action
Author | : Richard B. Silverman,Mark W. Holladay |
Publsiher | : Academic Press |
Total Pages | : 537 |
Release | : 2014-03-29 |
Genre | : Medical |
ISBN | : 9780123820310 |
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The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Medicinal Chemistry
Author | : Stanley M. Roberts,Barry J. Price |
Publsiher | : Unknown |
Total Pages | : 328 |
Release | : 1985 |
Genre | : Medical |
ISBN | : UOM:39015009576177 |
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The Organic Chemistry of Drug Design and Drug Action
Author | : Richard B. Silverman |
Publsiher | : Elsevier |
Total Pages | : 650 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 9780080513379 |
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Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
The Organic Chemistry of Drug Design and Drug Action
![The Organic Chemistry of Drug Design and Drug Action](https://youbookinc.com/wp-content/uploads/2024/06/cover.jpg)
Author | : Richard B. Silverman |
Publsiher | : Academic Press |
Total Pages | : 0 |
Release | : 1992 |
Genre | : Bioorganic chemistry |
ISBN | : 0443158622 |
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