Organization And Assembly Of Plant And Animal Extracellular Matrix

Organization and Assembly of Plant and Animal Extracellular Matrix presents a state-of-the-art view of some of the experimental systems in plant and animal matrix biology. It discusses certain principles underlying establishment of complex three-dimensional architecture cross broad evolutionary boundaries. The opening chapter reviews studies on the cellular mechanisms responsible for storage, release, assembly, and function of extracellular matrices during early sea urchin development. The subsequent chapters describe the structure, assembly, disassembly, and molecular biology of the Chlamydomonas reinhardtii cell wall. The chapters also summarize the status of work on basement membrane assembly. Important insights into approaches to identify critical molecular domains and the complexity of relating defined molecular associations to establishment of matrix architecture are provided. A family of discovered cell wall genes that encode protein products containing up to 70% glycine is presented in Chapter 4. This is followed by a discussion on the role of alginate self-assembly in cell wall formation in Fucus. The book goes on to address the issue of protein-carbohydrate recognition with a detailed discussion of plant and animal lectins. Chapter 7 tackles a family of genes encoding higher plant hydroxyproline-rich glycoproteins (HRGPs) and the relationship between the HRGP genes cloned and their products. The final two chapters are devoted to one of the most important classes of protein modifying enzymes for extracellular matrix formation and function, the prolyl hydroxylases. This book will be of help to workers in plant and animal matrix in understanding information, approaches, and ideas that they may not normally encounter.

The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling

The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries being revised and updated * Includes new entries on proteinases involved in the deposition of the extracellular matrix * Presents 3D ribbon diagrams in cases where the protein structure is now known

Discussing methods of enzyme purification, characterization, isolation, and identification, this book details the chemistry, behavior, and physicochemical properties of enzymes to control, enhance, or inhibit enzymatic activity for improved taste, texture, shelf-life, nutritional value, and process tolerance of foods and food products. The book cov

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Extracellular Matrix Genes provides some of the interesting complexities of the structure of the entire family of extracellular matrix genes. This book illustrates the permanent role that molecular biology and molecular genetics play in the detailed understanding of the normal biology of extracellular matrix. Organized into 10 chapters, this book begins with an overview of the structural and sequence aspects of the entire family of genomic sequences with a view to establishing common functional domains among collagens and their genes. This text then examines the status of the literature concerning human types. III and V. Other chapters consider the FACIT collagen gene family. This book discusses as well the development in understanding the structure of small proteoglycan core proteins and their role in proteoglycan biosynthesis and function as a result of their molecular cloning and expression. The final chapter deals with mutations in collagen genes. This book is a valuable resource for biochemists.

Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers.