Pediatric Pharmacology And Drug Therapy An Issue Of Pediatric Clinics Of North America

Dr. Aranda is an top expert in the area of pharmacology in the pediatric population. His issue has knowledgeable authors presenting clinical reviews on a wide variety of topics, from "hot areas " of drug therapy to drug abuse in children as well as current areas of debate in neonatal drug therapy. Articles are devoted to the following topics: New and Current Drug Therapies For Asthma In Children; Psychopharmacology Of Bipolar Disorders in Children and Adolescents; Designer Drug Abuse in School Children; Dietary Supplements in Children; Anticoagulant Therapies in Children; New Antimicrobials for Gram-Positive Infections in Children; Probiotics in Newborns And Children; Anticonvulsant Therapies in Newborns and Children; Immunomodulator Drug Therapies in Inflammatory Bowel Diseases in Children; Non-Steroidal Anti-Inflammatory Drugs in Newborns and Children; Metformin Use in Pre-Diabetic Children and Adolescents; Problems in Drug Dosing of Obese Children; Inhaled Drugs and Systemic Steroids for Bronchopulmonary Dysplasia; Antifungal Drugs in Newborns and Children; Antiviral Drugs In Newborns and Children; and Development of Drug Therapies for Newborns and Children. Readers will come away with the latest clinical information to help inform them when diagnosing and prescribing for children.

Dr. Aranda is an top expert in the area of pharmacology in the pediatric population. His issue has knowledgeable authors presenting clinical reviews on a wide variety of topics, from "hot areas " of drug therapy to drug abuse in children as well as current areas of debate in neonatal drug therapy. Articles are devoted to the following topics: New and Current Drug Therapies For Asthma In Children; Psychopharmacology Of Bipolar Disorders in Children and Adolescents; Designer Drug Abuse in School Children; Dietary Supplements in Children; Anticoagulant Therapies in Children; New Antimicrobials for Gram-Positive Infections in Children; Probiotics in Newborns And Children; Anticonvulsant Therapies in Newborns and Children; Immunomodulator Drug Therapies in Inflammatory Bowel Diseases in Children; Non-Steroidal Anti-Inflammatory Drugs in Newborns and Children; Metformin Use in Pre-Diabetic Children and Adolescents; Problems in Drug Dosing of Obese Children; Inhaled Drugs and Systemic Steroids for Bronchopulmonary Dysplasia; Antifungal Drugs in Newborns and Children; Antiviral Drugs In Newborns and Children; and Development of Drug Therapies for Newborns and Children. Readers will come away with the latest clinical information to help inform them when diagnosing and prescribing for children.

The need for safe and effective use of medicines in children and WHO's initiative "Make Medicines Child Size" have boosted research and educational activities in the area of pediatric clinical drug research. This issue focuses on both general and specific aspects of neonatal and pediatric clinical pharmacology including ethics, pharmacogenomics, metabolomics, adverse drug reactions, pain medication, pulmonary hypertension and several other hot topics. The editors have been able to find outstanding authors for the different parts on neonatal and pediatric pharmacology.

The topics in this issue represent the most current research areas of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). The CPCCRN is a national pediatric critical care research network that is charged with investigating the efficacy of treatment and management strategies to care for critically ill and injured children, as well as to better understand the pathophysiological basis of critical illness and injury in childhood. The proposed authors are past and present principal and co-investigators affiliated with the CPCCRN; the proposed topics represent the individual author’s area of clinical and research expertise. Each review article is an up-to-date review of the topic relevant to practicing clinicians and trainees in critical care medicine, with incorporation of the most recently published research findings pertinent to the topic, some of which may be the author’s own. The specific articles are devoted to the following topics: Cardiopulmonary resuscitation in pediatric and cardiac ICU; Approach to the critically ill pediatric trauma patient; Transfusion Decision Making in Pediatric Critical Illness; Pathophysiology and management of ARDS in children; Ventilator associate pneumonias in critically ill children; Mechanical ventilation and decision support in pediatric intensive care; Inflammation, pathobiology, phenotypes and sepsis: From meningococcemia to H1N1-MRSA, to Ebola; Immune paralysis in pediatric critical care; Molecular biology of critical illness; Sedation in pediatric critical illness; Delirium in pediatric critical illness; Challenges of drug development in pediatric intensive care; Potential of All Steroid Hormone Subclasses as Adjunctive Treatment for Sepsis; Morbidity: Changing the outcome paradigm; and End-of-Life and Bereavement Care in Pediatric Intensive Care Units.

The Guest Editors have tapped top key opinion leaders to provide current reviews on the clinical diagnosis and treatment of gastrointestinal disease in children. They have focused on topics related to GERD; Celiac Disease and Gluten Sensitivity; IBD; Motility Disorders; GI Bleeding and Management; Pancreatic Disorders; Hepatitis B and C; Liver Transplant; Abdominal Pain; Complications from Obesity; and Neonatal Cholestasis.These articles will provide a state-of-the-art overview of diagnosis and treatment of GI diseases that are impactful for the general pediatrician.

The guest editors have compiled expert authors to provide current updates on the clinical management of inborn errors of metabolism. Authors have contributed clinical review articles on the following topics: Inborn errors of metabolism overview: pathophysiology, manifestations, evaluation, and management; Inborn errors of metabolism with acidosis: organic acidemias and defects of pyruvate and ketone body metabolism; Inborn errors of metabolism with hyperammonemia: urea cycle defects and related disorders; Inborn errors of metabolism with hypoglycemia: glycogen storage diseases and gluconeogenesis defects; Inborn errors of metabolism with myopathy: defects of fatty acid oxidation and carnitine transport; Inborn errors of metabolism with seizures: defects of glycine and serine metabolism and co-factor related disorders; Inborn errors of metabolism with hepatopathy: metabolism defects of galactose, fructose, and tyrosine; Inborn errors of metabolism with cognitive impairment: metabolism defects of phenylalanine, homocysteine and methionine, purine and pyrimidine, and creatine; Inborn errors of metabolism with movement disorders: defects in metal transport and neurotransmitter metabolism; Inborn errors of metabolism involving complex molecules: lysosomal and peroxisomal storage diseases; Inborn errors of metabolism with complex phenotypes: mitochondrial disorders and congenital disorders of glycosylation; and Newborn screening: history, current status, and future directions.

This issue will provide a current update on diagnosis, treatment, and management of children with being hematological disorders. Dr. Callaghan has put together a comprehensive issue with clinical reviews written by top experts in the field. Articles are devoted to the following topics: Hemophilia; Sickle cell acute chest; Sickle cell drugs; Sickle cell gene therapy; Sickle cell menses and pain; Pediatric DVT; Atypical HUS; von Willebrand Disease; Female bleeding; Functional platelet disorders; Hemolytic anemia; Advocacy in hematology; ITP; and Acquired aplastic anemia. Readers will come away with the current clinical information they need to improve clinical outcomes.