Pharmaceutical Achievers

This biographical collection highlights individuals who made outstanding achievements in the arenas of pharmaceuticals and biotechnology. Pharmaceutical Achievers presents chronologically the major directions of pharmaceutical research and, in their historical context, the breakthroughs in treating various diseases. It concludes with a look at tomorrow's medicines. This work is particularly useful in the classroom, where its accounts of challenges and triumphs may inspire students to consider careers that support pharmaceutical research and development.

This book was designed to help teachers supplement science curricula with human stories of discovery in the chemical sciences. Chemical Achievers presents the lives and work of two types of achievers. First are the historical greats, those chemical scientists most often referred to in introductory courses. Second are those scientists who made contributions in areas of the chemical sciences that are of special relevance to modern life and the career choices students will make. The human faces summarized in this book range from Robert Boyle to Glenn Seaborg and Stephanie Kwolek. In this lively and comprehensive collection of photographs and biographies, Bowden illuminates how much the chemical sciences owe to the individual achiever. Over 150 images can be easily reproduced as overhead transparencies or other visual teaching aids.

BEST BOOKS OF MARCH - APPLE BOOKS TOP TEN PICKS FOR MARCH BOOKS - CHRISTIAN SCIENCE MONITOR BEST TRUE CRIME PICKS IN MARCH - CRIMEREADS MOST ANTICIPATED BOOKS OF 2020 - LITHUB Award-winning journalist and New York Times bestselling author Gerald Posner traces the heroes and villains of the trillion-dollar-a-year pharmaceutical industry and uncovers how those once entrusted with improving life have often betrayed that ideal to corruption and reckless profiteering—with deadly consequences. Pharmaceutical breakthroughs such as anti­biotics and vaccines rank among some of the greatest advancements in human history. Yet exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on pre­scription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry. Pharma introduces brilliant scientists, in-corruptible government regulators, and brave whistleblowers facing off against company exec­utives often blinded by greed. A business that profits from treating ills can create far deadlier problems than it cures. Addictive products are part of the industry’s DNA, from the days when corner drugstores sold morphine, heroin, and cocaine, to the past two decades of dangerously overprescribed opioids. Pharma also uncovers the real story of the Sacklers, the family that became one of America’s wealthiest from the success of OxyContin, their blockbuster narcotic painkiller at the center of the opioid crisis. Relying on thousands of pages of government and corporate archives, dozens of hours of interviews with insiders, and previously classified FBI files, Posner exposes the secrets of the Sacklers’ rise to power—revelations that have long been buried under a byzantine web of interlocking companies with ever-changing names and hidden owners. The unexpected twists and turns of the Sackler family saga are told against the startling chronicle of a powerful industry that sits at the intersection of public health and profits. Pharma reveals how and why American drug com­panies have put earnings ahead of patients.

Since ancient times the search for cures for the great scourges that have afflicted humankind has been an ongoing quest, but it is only within the last 200 years that major breakthroughs have occurred and the development of modern medicine has accelerated. The stories behind these miraculous cures are those of intense rivalries and jealousies, bitter public humiliation, unswerving dedication, subterfuge, and great personal struggles. Often these medical advances have truly changed the world. When Edward Jenner developed the concept of vaccination, and with it the cure for smallpox, he found a way to defeat a disease that had affected half a billion people — more than all those affected by wars and other epidemics combined. And while the Black Death still lingers in pockets around the world, it no longer threatens to destroy entire civilisations as it once did. SMALLPOX, SYPHILIS AND SALVATION uncovers the compelling stories of the men and women, innovations and accidents that have led to diseases from polio to syphilis, diphtheria to diabetes, tetanus to leukaemia no longer being the death sentences they once were. It also sounds a note of warning — for some of these diseases are fighting back. It is estimated that tuberculosis now claims one life every fifteen seconds, while new 'superbugs' are resistant to penicillin and other antibiotics. Diseases may once again threaten to crush the world's population, either in the form of biological warfare or simply because they want to survive as much as we do ...

Presents a history of chemistry, providing definitions and explanations of related topics, plus brief biographies of scientists of the 20th century.

This Brief takes the reader on a chemical journey by following the history for over two centuries of how an opiate became an opioid, thus spawning an empire and a series of crises. These imperfect resemblances of alkaloids are both natural and synthetic substances that, particularly in America, are continually part of a growing concern about overuse. This seemed an inviting prospect for those in pain, but as the ubiquitous media coverage continues to lay bare, the levels of abuse point to the fact that perhaps an epidemic is upon us, if not a culture war. Seeking answers to how and why this addiction crisis transpired over two hundred years of long development, this Brief examines the role that the chemistry laboratory played in turning patients into consumers. By utilizing a host of diverse sources, this Brief seeks to trace the design and the production of opioids and their antecedents over the past two centuries. From the isolation and development of the first alkaloids with morphine that relieved pain within the home and on the battlefield, to the widespread use of nostrums and the addiction crisis that ensued, to the dissemination of drugs by what became known as Big Pharma after the World Wars; and finally, to competition from home-made pharmaceuticals, the progenitor was always, in some form, a type of chemistry lab. At times, the laboratory pressed science to think deeply about society's maladies, such as curing disease and alleviating pain, in order to look for new opportunities in the name of progress. Despite the best intentions opioids have created a paradox of pain as they were manipulated by creating relief with synthetic precision and influencing a dystopian vision. Thus, influence came in many forms, from governments, from the medical community, and from the entrepreneurial aspirations of the general populace. For better, but mostly for worse, all played a role in changing forever the trajectory of what started with the isolation of a compound in Germany. Combining chemistry and history in a rousing new long-form narrative that even broadens the definition of a laboratory, the origins and future of this complicated topic are carefully examined.

The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful.

For millennia, human survival depended on our innate abilities to fight pathogens and repair injuries. Only recently has medical science prolonged longevity and improved quality of life. Physicians and academic researchers contribute to such progress, but the principal contributor is private industry that produces the tools – drugs and medical devices – enabling doctors to prevent and cure disease. Heavy regulation and biology’s complexity and unpredictability make medical innovation extremely difficult and expensive. Pharmaphobia describes how an ideological crusade, stretching over the last quarter century, has used distortion and flawed logic to make medical innovation even harder in a misguided pursuit of theoretical professional purity. Bureaucrats, reporters, politicians, and predatory lawyers have built careers attacking the medical products industry, belittling its critical contributions to medical innovation and accusing it of non-existent malfeasance: overselling product value, flaunting safety and corrupting physicians and academics who partner with it. The mania has imposed “conflict-of-interest” regulations limiting or banning valuable interactions between industry and physicians and researchers and diverting scarce resources from innovation to compliance. The victims are patients suffering from cancer, dementia, and other serious diseases for which new treatments are delayed, reduced, or eliminated as a result of these pointless regulations. With breathtaking detail, Thomas Stossel shows how this attack on doctors who work with industry limits medical innovation and inhibits the process of bringing new products into medical care.