Synuclein and the Coelacanth

Synuclein and the Coelacanth
Author: James M. Gruschus
Publsiher: Academic Press
Total Pages: 314
Release: 2021-01-31
Genre: Medical
ISBN: 9780323899680

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Most neurodegenerative diseases have animal parallels such as Alzheimer’s in chimpanzees, multiple sclerosis in macaques, Lou Gehrig’s disease in dogs, but nothing like Parkinson’s has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson’s disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson’s and actually halt the disease. Proposes a new hypothesis on the origins of Parkinson’s disease Examines genetic risk factors, environmental toxins, and neuroanatomy of PD Highlights new therapeutic treatment options in development for patients

Evolution of the Protein Synthesis Machinery and Its Regulation

Evolution of the Protein Synthesis Machinery and Its Regulation
Author: Greco Hernández,Rosemary Jagus
Publsiher: Springer
Total Pages: 564
Release: 2016-08-10
Genre: Science
ISBN: 9783319394688

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The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.

From Fossils to Mind

From Fossils to Mind
Author: Anonim
Publsiher: Elsevier
Total Pages: 254
Release: 2023-02-23
Genre: Psychology
ISBN: 9780323991087

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From Fossils to Mind, Volume 275 in the Progress in Brain Research series, presents chapters on a variety of interesting topics, including What could our premammalian ancestors hear, see, smell, and touch? A review of ten years of research about cynodont paleoneurology, Endocasts of ornithopod dinosaurs: anatomy and comparison, Adaptationism and Structuralism in Brain Evolution Research, Genomic approaches for tracing the evolution of brain ageing and neurodegenerative diseases, Investigating the Coevolution of Language and Tools in the Brain: An ALE Meta-analysis of Neural Activation During Syntactic Processing and Tool Use, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research serials Updated release includes the latest information on From Fossils and Mind

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones
Author: Gregory Lloyd Blatch,Adrienne Lesley Edkins
Publsiher: Springer
Total Pages: 276
Release: 2014-12-08
Genre: Medical
ISBN: 9783319117317

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Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.