Pharmaceutical Powder And Particles
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Pharmaceutical Powder and Particles
Author | : Anthony J. Hickey,Stefano Giovagnoli |
Publsiher | : Springer |
Total Pages | : 108 |
Release | : 2018-08-13 |
Genre | : Medical |
ISBN | : 9783319912202 |
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This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.
Particle particle Adhesion In Pharmaceutical Powder Handling
Author | : Fridrun Podczeck |
Publsiher | : World Scientific |
Total Pages | : 256 |
Release | : 1998-07-31 |
Genre | : Medical |
ISBN | : 9781783262311 |
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This monograph describes the physical principles of adhesion between particles and surfaces. These principles are applied to pharmaceutical processes involved in the manufacture of solid dosage forms such as powders, granules, tablets and dry powder inhalations. To help in the understanding of these systems, physical properties of solid surfaces, and an introduction to the theory of friction is given. Techniques for measuring particle adhesion and fracture mechanical properties of powders are introduced, as far as these are relevant to the processes discussed. The philosophy of the book deviates from that of standard pharmaceutical textbooks, in that it focuses primarily on physical principles involved in the manufacture of dosage forms rather than describing these processes purely by observation.
Particles and Nanoparticles in Pharmaceutical Products
Author | : Henk G. Merkus,Gabriel M. H. Meesters,Wim Oostra |
Publsiher | : Springer |
Total Pages | : 455 |
Release | : 2018-09-06 |
Genre | : Technology & Engineering |
ISBN | : 9783319941745 |
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This edited volume brings together the expertise of numerous specialists on the topic of particles – their physical, chemical, pharmacological and toxicological characteristics – when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and porosity of particles with respect to how they impact the formulations and products in which they are used and the effective delivery of pharmaceutical active ingredients. It considers all dosage forms of pharmaceuticals involving particles, from powders to tablets, creams to ointments, and solutions to dry-powder inhalers, also including the latest nanomedicine products. Further, it discusses examples of particle toxicity, as well as the important subject of pharmaceutical industry regulations, guidelines and legislation. The book is of interest to researchers and practitioners who work on testing and developing pharmaceutical dosage and delivery systems.
Powder Technology and Pharmaceutical Processes
Author | : Dominique Chulia,Michel Deleuil,Yvette Pourcelot |
Publsiher | : Elsevier Science & Technology |
Total Pages | : 557 |
Release | : 1994 |
Genre | : Science |
ISBN | : 0444815333 |
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Hardbound. This volume offers a multidisciplinary approach to the operations most commonly used in processing solids in the field of pharmacy and also in the fields of fine chemicals, cosmetics, foods, etc. The authors combine the triple standpoint of formulation, physical characterization of materials and process engineering and have selected the basic facts needed to understand the phenomena by which molecules become particles, particles become granules and granules become tablets, extrudates, microcapsules, etc. These operations are then described in very practical terms, including assessment of their effectiveness and limitations, and critical steps are highlighted.About twenty operations carried out on divided solids are described, ranging from crystallization to formulation, in a manner intended to be within the grasp of all involved: it is not a book solely for specialists, but offers a multidisciplinary background and a methodological help to p
Particle Size Enlargement
Author | : C. E. Capes |
Publsiher | : Elsevier |
Total Pages | : 205 |
Release | : 2013-10-22 |
Genre | : Science |
ISBN | : 9781483275079 |
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Handbook of Powder Technology, Volume 1: Particle Size Enlargement is the first of a series which will together form a Handbook of Powder Technology, primarily intended for engineers and scientists working in industry. The scope of the Handbook can be defined as being concerned with that part of chemical engineering which deals with processes involving the handling and treatment of material in solid particulate form. This book deals with methods used to create larger entities from fine particles so that the bulk properties of particulates can be improved. These so-called ""size enlargement"" methods evidently concern a broad spectrum of technical disciplines and industries ranging from the relatively small scale requirements of pharmaceutical manufacturers through the tonnage requirements of the fertilizer and minerals processing industries. A primary objective in preparing this book was to present a generalized account of the many size enlargement techniques scattered throughout these diverse industries, with emphasis on similarities and unifying characteristics whenever possible. The book devotes one chapter to each of the principal methods used to bring particles together into agglomerates: agitation methods— tumbling agglomeration, agitation methods—mixer agglomeration, pressure methods, thermal methods, spray and dispersion methods, and agglomeration from liquids.
Fine Particles in Medicine and Pharmacy
Author | : Egon Matijević |
Publsiher | : Springer Science & Business Media |
Total Pages | : 356 |
Release | : 2011-09-18 |
Genre | : Science |
ISBN | : 9781461403791 |
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Pharmaceutical manufacture is very exacting – for example, drugs must be uniform in size, shape, efficacy, bioavailability, and safety. The presence of different polymorphs in drug production is a serious problem, since different polymorphs differ in bioavailability, solubility, dissolution rate, chemical and physical stability, melting point, color, filterability, density, and flow properties. Fine Particles in Medicine and Pharmacy discusses particle size, shape, and composition and how they determine the choice of polymorph of a drug.
A Guide to Pharmaceutical Particulate Science
Author | : Anthony J. Hickey,Timothy M. Crowder,Margaret D. Louey,Norman Orr |
Publsiher | : CRC Press |
Total Pages | : 256 |
Release | : 2003-03-12 |
Genre | : Medical |
ISBN | : 113545793X |
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The pharmaceutical applications of powder technology have long been recognized. Yet while many books focus on aspects of powder formation and behavior, there has been no text that explores the power of particulate science in the design, manufacture, and control of quality medicines. Until now. A Guide to Pharmaceutical Particulate Science discusses key principles of particulate science and their practical applications. The authors cover particulate material, its form and production, sampling from bodies of powder, particle size descriptors and statistics, behavior of particles, instrumental analysis, particle size measurement and synergy of adopted techniques, physical behavior of a powder, and in vitro and in vivo performance criteria. They draw the components of particulate science into a single concise description of their current and potential uses in product development. Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, A Guide to Pharmaceutical Particulate Science gives readers the tools they need to grasp the science and its use in the industry.
Pharmaceutical Powder Compaction Technology
Author | : Metin Çelik |
Publsiher | : CRC Press |
Total Pages | : 360 |
Release | : 2016-04-19 |
Genre | : Medical |
ISBN | : 9781420089189 |
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Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists,