Pharmacology Of Intestinal Permeation Ii
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Pharmacology of Intestinal Permeation II
Author | : Anonim |
Publsiher | : Springer Science & Business Media |
Total Pages | : 600 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9783642695087 |
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The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200 m ) through which the body is exposed to its environ ment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a "leaky" epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. "Permeability" is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines the bioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a signigicant alteration of the physiological process of intestinal permeation.
Pharmacology of Intestinal Permeation II
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Author | : J. G. Banwell |
Publsiher | : Unknown |
Total Pages | : 616 |
Release | : 1984-09-01 |
Genre | : Electronic Book |
ISBN | : 3642695094 |
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Pharmacology of Intestinal Permeation I
Author | : Anonim |
Publsiher | : Springer Science & Business Media |
Total Pages | : 719 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9783642695056 |
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The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200m ) through which the body is exposed to its environment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a "leaky" epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. "Permeability" is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines thebioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a significant alteration of the physiological process of intestinal permeation.
Pharmacology of Intestinal Permeation
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 624 |
Release | : 1984 |
Genre | : Drugs |
ISBN | : UOM:39015007155164 |
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Pharmacology of Intestinal Permeation
Author | : W. McD. Armstrong |
Publsiher | : Springer |
Total Pages | : 746 |
Release | : 1984 |
Genre | : Medical |
ISBN | : UOM:39015007155156 |
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Pharmacology of Intestinal Permeation
Author | : W. McD. Armstrong |
Publsiher | : Springer |
Total Pages | : 744 |
Release | : 1984 |
Genre | : Medical |
ISBN | : NWU:35558000025805 |
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Oral Drug Absorption
Author | : Jennifer B. Dressman,Christos Reppas |
Publsiher | : CRC Press |
Total Pages | : 432 |
Release | : 2016-04-19 |
Genre | : Medical |
ISBN | : 9781420077346 |
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Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Protein Delivery
Author | : Lynda M. Sanders,R. Wayne Hendren |
Publsiher | : Springer Science & Business Media |
Total Pages | : 433 |
Release | : 2006-04-11 |
Genre | : Science |
ISBN | : 9780306468032 |
Download Protein Delivery Book in PDF, Epub and Kindle
Thirteen chapters by industrial and academic authorities in this rapidly evolving field present detailed case histories and reviews of current sophisticated protein-drug delivery technologies. Highlights include a comprehensive overview of insulin delivery and a discussion of the use of biodegradable microspheres.