Placebo Effects Through The Lens Of Translational Research

"The challenge of improving health outcomes for individuals and populations remains daunting. Fortunately, collaboration among multiple disciplines accelerates our appreciation of innate and external determinants of health for individuals and populations. Interprofessional research, education and practice also strengthens our capacity to design, disseminate, and deliver effective strategies and policies to prevent and treat diseases, and improve health"--

Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biological process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics. Latest placebo studies in clinically relevant models Current research and projects on the involved brain circuitry and neurotransmitter systems Specific chapters on applications

Placebo effects have been recognised by medicine and by science, yet only recently has systematic research begun to fully understand what they are and how they work. Sport and exercise scientists started systematic research to better understand the potential performance-enhancing effects of placebos as well as how a range of treatments are used in sport, from nutritional supplements to psychological interventions to sports medicine treatments. Placebo Effects in Sport and Exercise synthesises this field of research of the influence placebo effects have in sport and exercise. This book brings together many of the world’s leading and emerging placebo effect researchers to help readers gain an understanding of core research findings from within sports and exercise science as well as sport and exercise-related contributions from experts in anthropology, medicine, and neuroscience. Readers will gain an insight of what placebo and nocebo effects are, how they might influence sport and exercise performance and outcomes, and how they might significantly influence the effectiveness of performance and health interventions. The book investigates various practical and ethical implications for the sport and exercise practitioner, student, and researcher to consider. Can a placebo work if the athlete knows it’s a placebo? Should practitioners use placebos to enhance performance? Can the use of placebos reduce doping? Are some sports medicine treatments little more than placebos? With the rapid growth of applied sports medicine, as well as the concept of exercise as a mental health treatment in its own right, Placebo Effects in Sport and Exercise is key reading for students and researchers of sport psychology as well as those out in the field.

Firmly grounded in contemporary clinical practice and research, this pragmatic guide for professionals and students is now in a revised and expanded second edition. The book explains the theory underlying psychodynamic approaches and lays out a model for understanding psychopathology. Vivid case examples demonstrate how to tailor psychodynamic therapy effectively for individual patients. The authors provide a framework for diagnosing the patient’s core psychodynamic problem and engaging the most useful mechanisms of change, using an integrative approach. Special topics include remote and hybrid treatment, combining therapy with psychopharmacology, and working with couples and families. New to This Edition *Incorporates cutting-edge research on psychotherapy process and mechanisms of change. *Chapter on telepsychotherapy, including clear recommendations for practice. *More attention to the social determinants of health--the psychic effects of adversity and various forms of oppression. *New and revised case examples, with diversity in age, gender, race, culture, and sexual identity. See also Practicing Psychodynamic Therapy: A Casebook, edited by Summers and Barber, which features 12 in-depth cases that explicitly illustrate the approach in this book.

This work critically reviews the mechanisms of placebo effects across all medical conditions, diseases, and therapies. Exhaustive in its coverage, and written by a world authority in the field, it is the definitive text on the placebo effect, and essential for researchers and clinicians in all medical specialities.

This is the first book to critically review the mechanisms of placebo effects across all medical conditions, diseases and therapies. It is the definitive text on the placebo effect, and will be essential for researchers and clinicians in all medical specialities.

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

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