Precision Medicine for Autoimmune Diseases

Precision Medicine for Autoimmune Diseases
Author: Georg Lautscham
Publsiher: Academic Press
Total Pages: 0
Release: 2021-06-01
Genre: Medical
ISBN: 0128195223

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Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 Americans will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future.

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
Author: Michael Mahler
Publsiher: Academic Press
Total Pages: 300
Release: 2021-03-12
Genre: Science
ISBN: 9780323854320

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Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

Clinical Precision Medicine

Clinical Precision Medicine
Author: Judy S. Crabtree
Publsiher: Academic Press
Total Pages: 114
Release: 2019-11-15
Genre: Medical
ISBN: 9780128204023

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Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Towards Precision Medicine for Immune Mediated Disorders Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses

Towards Precision Medicine for Immune Mediated Disorders  Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses
Author: Xu-jie Zhou,Lam Cheung Tsoi,Amanda S. MacLeod
Publsiher: Frontiers Media SA
Total Pages: 227
Release: 2022-08-16
Genre: Medical
ISBN: 9782889765836

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Topic Editor Dr. MacLeod is employed by Janssen. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Early Rheumatoid Arthritis

Early Rheumatoid Arthritis
Author: Paul Emery
Publsiher: Unknown
Total Pages: 0
Release: 2005
Genre: Rheumatoid arthritis
ISBN: 141602767X

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This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.

Precision Medicine Role of Autoantibodies in the Prediction and Care of Autoimmune Diseases

Precision Medicine   Role of Autoantibodies in the Prediction and Care of Autoimmune Diseases
Author: Karsten Conrad,Luis E. C. Andrade Andrade,Edward K. L. Chan,Marvin J. Fritzler,Ger J. M. Pruijn,Yehuda Shoenfeld,Günter Steiner
Publsiher: Unknown
Total Pages: 0
Release: 2020
Genre: Electronic Book
ISBN: 3958535321

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The Autoimmune Diseases

The Autoimmune Diseases
Author: Noel R. Rose,Ian R. Mackay
Publsiher: Academic Press
Total Pages: 1532
Release: 2019-10-15
Genre: Medical
ISBN: 9780128122426

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The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
Author: Christopher Chang,Qianjin Lu
Publsiher: Springer
Total Pages: 403
Release: 2021-05-23
Genre: Medical
ISBN: 9811534519

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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.