Precision Psychiatry

Precision psychiatry, as outlined in this groundbreaking book, presents a new path forward. By integrating findings from basic and clinical neuroscience, clinical practice, and population-level data, the field seeks to develop therapeutic approaches tailored for specific individuals with a specific constellation of health issues, characteristics, strengths, and symptoms.

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

This book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. The concluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.

The American Psychiatric Association Publishing Textbook of Psychiatry, first published more than 30 years ago, is a landmark text with a legacy of sound scholarship, expert knowledge, and effective pedagogy. Thoroughly revised and featuring new authors and content, the seventh edition raises the bar, adding age-related, cultural, societal, and population considerations in the practice of psychiatry to the authoritative text that generations of students, residents, and clinicians have heretofore relied upon. The book first focuses on foundational knowledge, with chapters on psychiatric interviewing, diagnostic formulation, developmental assessment, laboratory testing and neuroimaging, and ethical and legal aspects of clinical psychiatry, and then proceeds to a full presentation of psychiatric disorders in alignment with DSM-5. The third section offers an overview of treatment strategies and methods in present-day psychiatry, a combination of evidence-based biological interventions and psychotherapies, and gives a clear sense of exciting new directions in psychiatric therapeutics. The final section of the textbook is focused on the care of special patient populations, including women; children and adolescents; lesbian, gay, bisexual, and transgender individuals; older adults; and culturally diverse individuals. Many topics are new to this volume, including the following: Suicide risk assessment, a critically important subject, is addressed in a new chapter that provides the reader with up-to-date knowledge needed to conduct a thorough, attuned, and accurate psychiatric interview in line with best practices. A new chapter on the social determinants of mental health has been added, reflecting an increased emphasis on populations whose specific concerns have been historically underappreciated in American psychiatry, and illuminating factors that influence mental health needs and barriers to care in specific patient populations. Precision psychiatry, an integrative approach that pulls together the scientific foundation of the discipline and recent technological advances and directs them toward closing the gap between discovery and clinical translation, is explored in a new chapter. E-health strategies in mental health have become increasingly available to psychiatrists and other health professionals, especially in the mobile and monitoring spheres. A new chapter offers insights into these intriguing new options for delivering treatment. A chapter on complementary and integrative therapies explores the integration of conventional medicine with alternative treatments for which there is an evidence base, providing an overview of nutrients, phytomedicines, hormones, mind--body practices, and electromagnetic treatments. With features such as key clinical points and recommended readings for further study, The American Psychiatric Association Publishing Textbook of Psychiatry is a comprehensive course book, an indispensable reference, and the ultimate resource for clinical care.

The book provides complete information on the cornerstones of precision medicine through the omics approach. Clinical applications of genomics and precision medicine have progressed from a theoretical wish list to an impactful force in medical practice.Step-by-step descriptions are provided from basics to the future application and its benefit in clinical practice. Precision medicine aims to personalize health care by tailoring decisions and treatments to each individual in every possible way. Precision medicine includes pharmacogenomics. Essential information is provided on the role of precision medicine and pharmacogenomics in the clinical practice of cancer, cardiovascular disease, diabetes, psychiatric disease, and also the importance for healthcare professionals. This book will assist the practitioners how to integrate precision medicine and pharmacogenomics data into their clinical practice. It is hoped that physicians, pharmacists, and scientists with basic scientific knowledge of precision medicine will findthis book useful.

Narrative practice has come under attack in the current "post-truth" era. In fact, many associate "narrative hermeneutics"--the field of inquiry concerned with reflection on the meaning and interpretation of stories--directly with this putative movement beyond truth. Challenging this view, The Use and Abuse of Stories argues that this broad arena of inquiry instead serves as a vitally important vehicle for addressing and redressing the social and political problems at hand. Hanna Meretoja and Mark Freeman have gathered an interdisciplinary group of esteemed authors to explore how interpretation is relevant to current discussions in narrative studies and to the broader debate that revolves around issues of truth, facts, and narrative. The contributions turn to the tradition of narrative hermeneutics to emphasize that narrative is a cultural meaning-making practice that is integral to how we make sense of who we are and who we could be. Addressing topics ranging from the dangers of political narratives to questions of truth in medical and psychiatric practice, this volume shows how narrative hermeneutics contributes to topical debates both in interdisciplinary narrative studies and in the current cultural and political situation in which issues of truth have gained new urgency.

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.