Prostate Cancer New Horizons In Research And Treatment

In recent years the pace of research in prostate cancer has increased dramatically. Creative ideas in combination with new and emerging technologies have led to an explosion of discovery. These types of advances in prostate cancer research presage an era of new treatment strategies based on an understanding of the cellular and molecular mechanisms of disease. In creating this book, we aimed to cover a broad "bench to bedside" research spectrum ranging from: genetic, molecular and cellular analyses to epidemiological studies, refinements in local treatment strategies and new biologically based non-hormonal treatments for systemic disease. Researchers and clinicians will find in this book a group of timely and clinically relevant chapters on prostate cancer research and treatment.

Although much has been written on surgical treatment for prostate cancer, this is the first book to present a comprehensive review of the new non-surgical therapies currently available in the management of prostate disease. This volume provides a detailed account of the key areas of treatment including, screening, early diagnosis of malignant disease, and the application of hormonal therapies for advanced prostate cancer. A 'continuum' approach to the management of malignant prostate disease is emphasized throughout the text. The editors are recognised international, as opinion leaders in the field of prostate cancer. In this single volume they offer the first balanced account of the new molecular and hormonal therapies currently available in the management of prostate cancer. It is intended that this volume should become the primary source of reference for all those, either in research or clinical practice who have an interest in combination therapy and the non-surgical treatment of prostate cancer. This book is published in full colour, with illustrations by Dee Mclean who is widely recognised as one of the leading medical artists working in this field.A unique feature of this volume is the inclusion of a CD.Rom which cross references to the text, providing a PowerPoint presentation, that also includes video clips, and animated graphics.

Prostate Cancer, Science and Clinical Practice, Second Edition, continues to be an important translational reference that bridges the gap between science and clinical medicine. It reviews the biological processes that can be implicated in the disease, reviews current treatments, highlights the pitfalls where relevant, and examines the scientific developments that might result in future treatments. Key chapters from the previous edition have been updated, and a plethora of new chapters describe new concepts of prostate cancer biology and newly developed therapeutics. Each chapter has been written by internationally recognized specialists on prostate cancer epidemiology, genetic susceptibility, cancer metastases, prostate physiology, proteomics, new therapeutics, and clinical trials. Presents a comprehensive, translational source for all aspects of prostate cancer in one reference work Provides a common language for cancer researchers, oncologists, and urologists to discuss prostate tumors and how prostate cancer metastases affects other major organ systems Offers insights to research clinicians, giving them a key understanding the molecular basis of prostate cancer Offers insights to cancer researchers into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers

This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current chemotherapy and immunotherapy regimens for genitourinary malignancies and discusses indications, outcomes, and toxicities, as well as clinical trial concepts. Each of the book’s chapters offers a bulleted box of clinical pearls on the particular role of the APP. Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider is a resource for urologists, uro-radiologists, medical clinicians and family practitioners alike, familiarizing its audiences with systemic therapy regimens for urologic malignancies, as well as their expected outcomes and side effects.

New Horizons in Natural Compound Research provides the latest updates in natural compound research (plant, microbes, algae, fungi) and their novel applications in health, agriculture and environment. The book gives recent advances in the extraction of natural compounds, cutting-edge approaches for natural compound purifications, and emerging trends in natural compound screening and identification. In addition, it provides a detailed explanation of the databases and libraries of natural compounds, as well as their significance. Sections focus on research and multidisciplinary practical techniques of natural product research, encouraging young scientists to pursue unique research while also generating strong research ideas. From a future perspective, this book acts as a guide to identify potential areas and new research opportunities in the field of natural products and their service towards human beings, animals and the environment. Provides a one–stop solution for concepts, cutting-edge techniques, methods, and novel applications of natural products in health and the environment Focuses on current gaps in natural product research, as well as methodologies and techniques to assist researchers in resolving existing challenges and speeding up the pace of drug discovery from natural sources Highlights new avenues of natural product research Contains contributions from well-experienced researchers from academia, research institutes and top-notch young scientists from industry

Prostate cancer continues to be a major threat to men's health, thesecond most common cancer in men, in many countries. Therefore itis increasingly important that those faced with difficult clinicalquestions make the right decisions. Since the first volume waspublished in 2000, many debates persist but new controversies havealso emerged, reflected in the chapters of this new volume. Newauthors have been recruited to give their insight into newer areasof this controversial topic. Challenges in prostate cancer provides a series ofstate-of-the-art review articles, each of which addresses andanswers a contentious question. It includes chapters on medical andsurgical management of all stages of prostate cancer, clinicalinvestigation, epidemiology, clinical trials and basic scientificresearch and covers issues such as the genetic basis of cancer,clinical economics and influence. The authors have used their expertise to distil the availableevidence into practical advice to be used by busy urologists intheir day-to-day practice. And as well as being an overview ofcurrent practice many chapters attempt to give insights into thefuture direction of prostate cancer research and clinicalmanagement.