Protein Phosphorylation
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Protein Phosphorylation
Author | : D. Grahame Hardie |
Publsiher | : IRL Press |
Total Pages | : 336 |
Release | : 1993 |
Genre | : Science |
ISBN | : UOM:39015029947499 |
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Reversible phosphorylation is one of the major mechanisms by which protein activity is controlled in all eukaryotic cells. Networks of protein kinases and phosphatases, which catalyze phosphorylation and dephosphorylation respectively, are responsible for switching between different pathways of cell division, development, or differentiation in response to hormones or growth factors. This book provides a comprehensive description of current methods for studying protein phosphorylation and the protein kinases and phosphatases which catalyze it. It includes detailed protocols for studying phosphorylation in intact cells, approaches using enzyme inhibitors, purification of serine/threonine-specific protein kinases/phosphatases, analysis of kinase/phosphatase specificity, and cloning relevant cDNAs. Protein Phosphorylation: A Practical Approach will be of great value to all researchers in the fields of intracellular and intercellular signalling, including biochemists, molecular biologists and pharmacologists.
Signal Transduction and Protein Phosphorylation
Author | : L.M.G. Heilmeyer |
Publsiher | : Springer Science & Business Media |
Total Pages | : 370 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 9781475701661 |
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Protein Phosphorylation
Author | : Friedrich Marks |
Publsiher | : John Wiley & Sons |
Total Pages | : 404 |
Release | : 2008-09-26 |
Genre | : Science |
ISBN | : 9783527615025 |
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Protein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature.
Peptides and Protein Phosphorylation
Author | : B.E. Kemp |
Publsiher | : CRC Press |
Total Pages | : 332 |
Release | : 2018-01-18 |
Genre | : Medical |
ISBN | : 9781351083898 |
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This comprehensive volume focuses on the ways in which synthetic peptides have been exploited in order to expand our understanding of the molecular mechanisms involved in protein phosphorylation. It recognizes that virtually all physiological processes are regulated by protein phosphorylation. It discusses the use of synthetic peptides in studying the catalytic mechanism and regulation of protein kinases. It also includes the chemical synthesis of phosphorylated peptides and preparation of specific antisera. This incredible work has lead to the development of a new generation of peptide inhibitors with potencies of greater magnitude than those previously known. Everyone involved with biochemistry and molecular biology will find this one-of-a-kind resource fascinating and filled with useful information.
Protein Phosphorylation in Cell Growth Regulation
Author | : Michael J. Clemens |
Publsiher | : CRC Press |
Total Pages | : 300 |
Release | : 1996-12-03 |
Genre | : Medical |
ISBN | : 9057020300 |
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The aim of this text is to integrate the processes of protein phosphorylation and dephosphorylation into the complex pathways by which cellular proliferation is driven, bringing together the many different systems of control implicated in the regulation of cell growth. Presents a survey of protein phosphorylation roles in the control of cellular proliferation and differentiation. A large number of protein kinases and phosphatases have been characterised in higher cells, and have been shown to be involved in signal transduction pathways by which growth factors, mitogens, and extracellular agents exert proliferative effects on cells. Important subjects covered include control of gene expression at the transcriptional and translational levels, and roles of the cdk kinases and cyclins in cell cycles regulation. Describes all major families of protein kinases of significance to growth regulation.
Protein Phosphorylation in Health and Disease
Author | : Shirish Shenolikar |
Publsiher | : Academic Press |
Total Pages | : 464 |
Release | : 2012-02-28 |
Genre | : Medical |
ISBN | : 9780123964564 |
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This volume explores some of the most exciting recent advances in basic research on protein phosphorylation in health and disease and how this knowledge is leading to advances in the various fields. Contributions from leading authorities Informs and updates on all the latest developments in the field
Protein Phosphorylation in Human Health
Author | : Cai Huang |
Publsiher | : BoD – Books on Demand |
Total Pages | : 482 |
Release | : 2012-09-06 |
Genre | : Medical |
ISBN | : 9789535107378 |
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15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.
Reversible Protein Phosphorylation in Cell Regulation
Author | : R.L. Khandelwal,J.H. Wang |
Publsiher | : Springer Science & Business Media |
Total Pages | : 314 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 9781461526001 |
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This book, published in association with the journal MOLECULAR AND CELLULAR BIOCHEMISTRY, is dedicated to Ed Krebs and Eddy Fischer in celebration of their 1992 Nobel Prize in Physiology and Medicine. Reversible protein phosphorylation is a research field pioneered and developed by Krebs and Fischer. This book contains short reviews and original research papers contributed by Krebs and Fischer's coworkers, both former and current. The contents reflect the two-way interaction between protein phosphorylation and other biomedical research fields. The chapters are grouped into four sections. The first two deal with structure/function aspects of protein kinases and protein mechanisms. Unlike many other research fields, which undergo periods of intense activity and productivity followed by relative calm, the protein phosphorylation field enjoyed continued growth both in scope and intensity, and the pace of this growth has increased markedly in recent years. This volume will provide a glimpse of the dynamism and diversity of the research activity representative of the current state of the field.