Psychiatric Neuroimaging

The past decade has witnessed tremendous progress in psychiatric neuroimaging research. Investigators have developed, in tandem with significant advances in imaging technology, innovative strategies for exploiting the awesome potential of these new tools. This volume brings you up to date on the latest developments by providing insight into the methodology of experimental design of the numerous neuroimaging articles being published in today's peer-reviewed journals. Revealing the remarkable wealth of neuroimaging's potential contributions to psychiatry, 49 distinguished contributors use accounts of their own research to illustrate the power of particular paradigmatic techniques. These techniques hold promise not only for delineating pathophysiology and advancing neuroscience, but also for yielding discoveries of direct clinical significance, such as diagnostic testing, predictors of treatment response, and new medications. Focused specifically on applications in psychiatry, these chapters are uniquely organized around experimental paradigms rather than psychiatric disorders: Using magnetic resonance imaging (MRI) to detect and characterize subtle, easily overlooked abnormalities in schizophrenia and schizotypal personality disorder. Testing specific hypotheses regarding the functional integrity of implicated neural systems within the brain as part of cognitive activation studies of schizophrenia and obsessive-compulsive disorder (OCD). Assessing the roles of the amygdala and striatum in anxiety disorders, including masked stimuli and other task manipulation methods to assay nonconscious brain activity. Investigating the neural correlates of psychiatric symptoms in anxiety disorders, using script-driven imagery and in vivo exposure to experimentally manipulate study conditions. Capturing the often elusive symptoms of hallucinations and psychomotor tics using innovative imaging techniques. Using transcranial magnetic stimulation (TMS) to investigate how the brain regulates mood. Other fascinating topics include using positron emission tomography (PET) and single photon emission computed tomography (SPECT) to discern the therapeutic mechanisms of psychotropic medications and enhance the development of new medications; integrating structural and functional imaging to treat major depression; using magnetic resonance spectroscopy (MRS) to quantify brain concentrations of exogenous compounds; using MRI to visualize circuits implicated in developmental disorders such as attention-deficit/hyperactivity disorder (ADHD) and anxiety, including ground-breaking studies of children; using functional MRI in animals and its applications in psychiatric research; and exploring the use of neuroimaging methods to investigate genetic contributions to normal cognitive function. Specialists and general clinicians alike will find much of interest in this definitive look at the exciting developments in neuroimaging today and how they can enhance our understanding and treatment of psychiatric disorders. This comprehensive text with its extensive illustrations and annotations will also prove a welcome addition to any course in the neurosciences.

New neuroimaging techniques are developing at a break neck pace-every academic journal contains glossy pictures of brain activity corresponding to a particular task emblazoned in glorious technicolor. Discoveries about brain function in psychiatric disorders have been made at an equally rapid rate. However, most books on the subject have been writt

This important volume is the first to address the use of neuroimaging in civil and criminal forensic contexts and to include discussion of prior precedents and court decisions. Equally useful for practicing psychiatrists and psychologists, it reviews both the legal and ethical consideraitons of neuroimaging.

Neuroimaging and Neurophysiology in Psychiatry is an invaluable guide through the methods and applications of neuroimaging and neurophysiology.

This book presents the state of the art in the use of neuroimaging technologies in the study of schizophrenia and other primary psychotic disorders. The contributions of neuroimaging in the characterization of these disorders are reviewed across diagnoses, by focusing on psychopathological domains and at-risk populations in order to understand the implications for treatment. The principal neuroimaging findings are described in detail, identifying those that are common to and specific for each disorder and highlighting important pitfalls. Attention is drawn to potential translational aspects of research in the field, with discussion of emerging innovative perspectives. Neuroimaging research has shown that abnormalities of brain structure and function associated with psychiatric disorders do not reflect the boundaries of current diagnostic categories. However, neuroimaging findings are being reconsidered in the light of recent research proposals aimed at re-conceptualizing classification systems in Psychiatry. Written by leading experts, this book will appeal to all with an interest in the field, including researchers, clinicians, and trainees.

An introduction to Neuroimaging and Neurophysiology in Psychiatry, this book explains the basic physics and physiology behind the main techniques of neuroimaging, including MRI and PET, and non-invasive neurophysiology. This title covers all the clinically relevant aspects of neuroimaging and neurophysiology methods. It includes individual chapters on techniques, diagnostic disease markers, and neurophysiological treatments to ensure psychiatrists are familiar with the clinical relevance of reported abnormalities. With the latest research, Neuroimaging and Neurophysiology in Psychiatry is an invaluable and easy-to-read reference that will help practising psychiatrists in the evaluation of the use of neuroimaging methods in clinical, research, and forensic settings.

The use of neuroimaging studies in psychiatry is exploding -- and offers tremendous potential for practicing clinicians. Yet if you're like many psychiatrists, you're sometimes uncertain about which studies to use in specific situations. Until now, you've had to sort through the only information available -- technical reviews in the literature -- for guidance. But no more. Essentials of Neuroimaging for Clinical Practice is an all-in-one resource that explains how to use these powerful techniques to improve outcomes. It demystifies neuroimaging with clear, concise, and practical advice on using today's most advanced applications in the diagnostic workup of patients. This practical clinical guide will help you achieve a solid understanding of the full range of neuroimaging modalities: Structural techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) Functional techniques such as positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and magnetic resonance spectroscopy (MRS) Other techniques such as electroencephalography (EEG) -- including quantitative EEG and event-related potentials -- and magnetoencephalography. For each modality, you'll find: A basic review of the technique -- trace the development of each modality, and become familiar with its underlying technology. Guidance on when to use it -- learn which techniques are best to use in specific clinical situations. Tips for ordering studies -- discover how to write up orders to obtain the most accurate and detailed information from each study, including when to use contrast and how to determine the best acquisition parameters. A look at its future potential in practice and research -- explore the current capabilities of each modality and the most promising strategies for improving diagnostic results. Filled with examples of real-life imaging studies, Essentials of Neuroimaging for Clinical Practice is a must-have tool for all practicing psychiatrists and psychologists. In addition, it will serve as an excellent clinical guide for residents -- and an outstanding text for courses in clinical neuroimaging for psychiatrists.