Pulmonary Drug Delivery Systems Material And Technological Advances

This book provides an insight into state-of-art developments in pulmonary drug delivery systems. It comprises several chapters covering a wide range of promising technologies and novel materials explored for developing effective pulmonary drug delivery systems. The initial book chapters elucidate role of thin film freezing, supercritical fluid technology, nano-in-micro particles system, crystal-engineered microstructures and porous particles in pulmonary drug delivery. The subsequent book chapters elaborate on various functional excipients such as chitosan, cyclodextrins, and Vitamin E-TPGS to attain local and systemic therapeutic action. There are book chapters focused on diverse novel carrier systems such as hydrogels, quantum dots, metal-organic framework, and prodrug approach. Additionally, book also contains chapters, exclusively dedicated to biologicals and numerical simulation in pulmonary therapeutics. The book chapters follow a sequential order, beginning with the pulmonary relevance of technology or polymeric materials, carrier synthesis schemes, current technical state-of-art, along with clinical, industrial, and regulatory aspects. Each chapter contains a future perspective section that will systematically reflect the current state of advances in pulmonary drug delivery. It also offers a practical basis for audience to understand the design and function of the delivery systems for better therapeutic outcomes. The book provides balanced views by considering the investigations from various scientific domains and industrial knowledge. Briefly, this book aims to collect, analyse, and bring together the latest developments in pulmonary drug delivery with more focus on materials and technologies. Indeed, this book is a valuable source for readers and researchers who wish to learn more about the advances in pulmonary drug delivery systems.

The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

Pulmonary drug delivery has been a rapidly expanding field, moving from the traditional propellant based metered dose inhaler delivery of small asthma drugs, to a broader landscape of new devices and novel drugs for local and systemic delivery. The field has greatly expanded yet the tools for pulmonary drug delivery systems have not kept pace with the potential applications. One of the key developments has been the use of polymers to achieve better control of pulmonary drug delivery. This has the potential to expand the toolbox available for researchers in the field to deliver their new chemical entities successfully to the lung. This book reviews the use of polymers in pulmonary drug delivery, encompassing polymers from their use in devices and packaging, in addition to their use as excipients in formulations delivered to the airways. The book is arranged by application and extensively reviews the technical and patent literature. This is the first volume totally dedicated to polymers in pulmonary drug delivery and should be the resource of choice for those in the field, especially managers in the pharma/biotech industry. Naturally, the text will be of great interest to academics and graduate students. Finally, regulatory affiliated scientists will also find this resource invaluable.

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.