Recent Advances In Application Of Synthetic Biology For Production Of Bioactive Compounds

Biotechnological Production of Bioactive Compounds provides insights on the most recent innovations, trends, concerns, solutions and practical challenges encountered in the fields of enzyme technology and nanobiotechnology for the production of bioactive materials with extra health benefits. As nanobiotechnology has improved the bioactive extraction process significantly, many bioactives, including bioflavonoids, omega-3 fatty acids, biopigments and low calorie sugar substitutes are a pivotal part of the food industry. The book highlights the production of extra health benefits “bioactives’’ from plants and microbes and explains how the extraction efficiency of bioactives molecules improves significantly with the recent advances in nanobiotechnology. Researchers in the fields of biochemical engineering, biotechnology, bioremediation, environmental sustainability and those in pharma industries will find the information in this book very helpful and illuminating. Outlines technological advances in bioactives extraction Covers bioflavonoids, biopigments, omega-3-fatty acids and low sugar substitutes Explains the mechanisms of Green cargo (biogenic nanoparticles) for the delivery of bioactive molecules

This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.

Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

Many plant-derived bioactive compounds are the foundation effective drugs to cure diseases. Usually, the bioactive compounds in plant biomass are low, and the extraction of bioactive compounds from plants is not eco-friendly, which limits their application in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast. Engineering biology for microbial biosynthesis of plant-derived bioactive compounds summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing this content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks. With a comprehensive coverage of the field, Engineering biology for microbial biosynthesis of plant-derived bioactive compounds is of great interest to undergraduate and graduate students, scientists, researchers as well as engineers who work on the microbial production of plant-derived bioactive compounds. Provides valuable information for engineers, scientists, and industrial researchers who want to obtain microbial strains with the ability of plant-derived bioactive compound production Guides microbial production of plant-derived bioactive compounds at the laboratory and industrial levels Ideal resource for anyone who works on the microbial production of plant-derived bioactive compounds

This book delves into microbial production and its implications for various industries and presents the latest advancements in the field of bioactive compound production by microorganisms. Divided into 16 chapters, the book covers a wide range of topics, starting with the emerging trends in microbial production techniques, followed by the potential of fungi and algae in producing bioactive compounds, and the applications of bioactive compounds in medicine, agriculture, and industry. Contributions from expert scientists emphasize the significance of metabolic engineering and modern analytical techniques for the extraction, purification, and structural characterization of microbial bioactive compounds. The authors also present alternative technologies and methodologies for the recovery and extraction of these compounds from microbial sources and highlight the health-promoting benefits of natural plant-derived bioactive compounds. Particular attention is given to nanocarriers and their potential for managing the delivery of bioactive compounds in therapeutic applications. The importance of actinomycetes and their bioactive potential in the agricultural sector is also discussed. In this book, readers will also find out about the importance of microbial community dynamics in Antarctica, their ecological potential, and their industrial application. The last chapter of the book offers an industrial perspective of microbial pigments and their applications. This book is a valuable resource for researchers, academics, and industry professionals seeking to understand and harness the potential of microbial bioactive compounds for sustainable development, industrial applications, and improved human well-being.

Since ancient times, plants have been used as a prime natural source of alternative medicines and have played an important role in our lives. The old tradition of medicinal plant application has turned into a highly profitable business in the global market, resulting in the release of a large number of herbal products. People have tried to find different sources of medicines to alleviate pain and cure different illnesses. Due to severe constraints of synthetic drugs and the increasing contraindications of their usage, there is a growing interest world over in the usage of natural products based on medicinal herbs, hence, there is an ever expanding market of herbs and herbal based medicinal preparations all over the world. This has culminated into an exponential increase in number of research groups in different geographical locations and generation of volume of research data in the field in a short span of time. The path breaking advancement in research methods and interdisciplinary approaches is giving birth to newer perspectives. Therefore, it becomes imperative to keep pace with the advancement in research and development in the field of medicinal herbs. There are a large number of researchers in different parts of the world working on various aspects of medicinal plants and ‘herbal medicines’. The idea is to bring their recent research work into light in the form of a book. The proposed book contains chapters by the eminent researchers in different countries and working with different disciplines of medicinal plants. Articles pertain to different disciplines such as: 1. Resources and conservation of medicinal plants 2. Biosynthesis and metabolic engineering of medicinal plants 3. Tissue culture, propagation and bioreactor technology of medicinal plants 4. Phytochemical research on medicinal plants 5. Herbal medicines and plant-derived agents in cancer prevention and therapy 6. Herbal medicines and plant-derived agents in metabolic syndrome management 7. Herbal medicines and plant-derived agents in modulation of immune-related disorders 8. Herbal medicines and hepatotoxicity The book will prove itself an asset for the researchers, professionals and also students in the area of medicinal plants and mechanism of their action.