Recent Applications Of Selected Name Reactions In The Total Synthesis Of Alkaloids

Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder, Friedel-Crafts, Heck, Mannich, Pauson-Khand, Pictet-Spengler, Sonogashira and Suzuki reactions. In this book, some selected name reactions in the total synthesis of alkaloids are covered, as they can be used as the key step/steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in both academia and industry. This book is also beneficial to biologists, pharmacists and botanists. Includes an introduction of alkaloids, their origins and biological properties Features the applications of special name reactions as the key step in the total synthesis of featured alkaloids Covers the pathway for the synthesis of alkaloids from commercially available or easily accessible starting materials by using at least one name reaction to achieve the desired target products

Studies in Natural Products Chemistry, Volume 78 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Heteropolyacids as Highly Efficient and Green Catalysts Applied in Organic Transformations introduces heteropolyacids (HPAs) as promising candidates for use as green catalysts. This book initially presents an overview of chemistry of HPAs, including the history of their discovery and applications, systematic classifications, solubility, coordination and binding chemistry, isomerization, stability, redox activity, acidic properties, basicity, skeleton structure, structure types, self-assemblage, surface area, electrochemical behavior, methods of investigation, and characterization. Other sections present and compare the applications of HPAs as homogeneous and heterogeneous catalysts. The book provides readers with a basic-to-advanced range of knowledge on how useful and green HPAs can be used for use as catalysts in organic transformations and even the synthesis of complex organic molecules. Focuses on applications of HPAs as catalysts, but also includes basic information on HPAs to make it useful to those researchers and scientists whose activities are focused on biochemical analysis, electrochemistry, electrochemical devices, protection of corrosion, medicine and photo-catalyzed reactions Includes a subdivision devoted to HPA-catalyzed multicomponent reactions for the synthesis of some biologically active compounds via a double-green strategy Illustrates reactions with approximately 100 chemical reaction schemes to aid understanding

Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.

References to literature (mostly journal articles) dealing with individual or classes of chemical compounds, name reactions, and specific processes or phenomena. Also includes foreign-language materials. Citations subdivided under each letter into sections dealing with compounds, name reactions, and processes or phenomena. Each entry gives chemical entity, author(s), and other bibliographical information.