Reconstructing The Tree Of Life

To document the world's diversity of species and reconstruct the tree of life we need to undertake some simple but mountainous tasks. Most importantly, we need to tackle species rich groups. We need to collect, name, and classify them, and then position them on the tree of life. We need to do this systematically across all groups of organisms and b

The Great Tree of Life is a concise, approachable treatment that surveys the concept of the Tree of Life, including chapters on its historical introduction and cultural connection. The Tree of Life is a metaphor used to describe the relationships between organisms, both living and extinct. It has been widely recognized that the relationship between the roughly 10 million species on earth drives the ecological system. This work covers options on how to build the tree, demonstrating its utility in drug discovery, curing disease, crop improvement, conservation biology and ecology, along with tactics on how to respond to the challenges of climate change. This book is a key aid on the improvement of our understanding of the relationships between species, the increasing and essential awareness of biodiversity, and the power of employing modern biology to build the tree of life. Provides a single reference describing the properties, history and utility of The Tree of Life Introduces phylogenetics and its applications in an approachable manner Written by experts on the Tree of Life Includes an online companion site containing various original videos to enhance the reader’s understanding and experience

In this New York Times bestseller and longlist nominee for the National Book Award, “our greatest living chronicler of the natural world” (The New York Times), David Quammen explains how recent discoveries in molecular biology affect our understanding of evolution and life’s history. In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important; we now know that roughly eight percent of the human genome arrived sideways by viral infection—a type of HGT. In The Tangled Tree, “the grandest tale in biology….David Quammen presents the science—and the scientists involved—with patience, candor, and flair” (Nature). We learn about the major players, such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health. “David Quammen proves to be an immensely well-informed guide to a complex story” (The Wall Street Journal). In The Tangled Tree, he explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life—including where we humans fit upon it. Thanks to new technologies, we now have the ability to alter even our genetic composition—through sideways insertions, as nature has long been doing. “The Tangled Tree is a source of wonder….Quammen has written a deep and daring intellectual adventure” (The Boston Globe).

This book presents an overview of current views on the origin of life and its earliest evolution. Each chapter describes key processes, environments and transition on the long road from geochemistry and astrochemistry to biochemistry and finally to the ancestors of today ́s organisms. This book combines the bottom-up and the top-down approaches to life including the origin of key chemical and structural features of living cells and the nature of abiotic factors that shaped these features in primordial environments. The book provides an overview of the topic as well as its state of the art for graduate students and newcomers to the field. It also serves as a reference for researchers in origins of life on Earth and beyond.

Through comparative analysis, the genomes of a number of species are providing a deeper understanding of the human genome. This is highly useful in drug research, especially in the treatment of otherwise intractable conditions. Compiling first-hand descriptions of the pioneering achievements of prominent researchers, this text focuses on revolutionary advances in DNA-sequencing technology, new approaches to the organization and analysis of large phylogenetic data sets, new perspectives on evolution, and the development of novel antimicrobial drugs. This seminal volume demonstrates both the means and the fruits of cooperation across a number of fields, and in doing so lays the groundwork for continued progress.

Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields.Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including wholeproteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized toprovide insights and inform future research.This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.

In December 2004, the National Academy of Sciences sponsored a colloquium on "Systematics and the Origin of Species" to celebrate Ernst Mayr's 100th anniversary and to explore current knowledge concerning the origin of species. In 1942, Ernst Mayr, one of the twentieth century's greatest scientists, published Systematics and the Origin of Species, a seminal book of the modern theory of evolution, where he advanced the significance of population variation in the understanding of evolutionary process and the origin of new species. Mayr formulated the transition from Linnaeus's static species concept to the dynamic species concept of the modern theory of evolution and emphasized the species as a community of populations, the role of reproductive isolation, and the ecological interactions between species. In addition to a preceding essay by Edward O. Wilson, this book includes the 16 papers presented by distinguished evolutionists at the colloquium. The papers are organized into sections covering the origins of species barriers, the processes of species divergence, the nature of species, the meaning of "species," and genomic approaches for understanding diversity and speciation.

This is the first book on "phylogenetic supertrees", a recent, but controversial development for inferring evolutionary trees. Rather than analyze the combined primary character data directly, supertree construction proceeds by combining the tree topologies derived from those data. This difference in strategy has allowed for the exciting possibility of larger, more complete phylogenies than are otherwise currently possible, with the potential to revolutionize evolutionarily-based research. This book provides a comprehensive look at supertrees, ranging from the methods used to build supertrees to the significance of supertrees to bioinformatic and biological research. Reviews of many the major supertree methods are provided and four new techniques, including a Bayesian implementation of supertrees, are described for the first time. The far-reaching impact of supertrees on biological research is highlighted both in general terms and through specific examples from diverse clades such as flowering plants, even-toed ungulates, and primates. The book also critically examines the many outstanding challenges and problem areas for this relatively new field, showing the way for supertree construction in the age of genomics. Interdisciplinary contributions from the majority of the leading authorities on supertree construction in all areas of the bioinformatic community (biology, computer sciences, and mathematics) will ensure that this book is a valuable reference with wide appeal to anyone interested in phylogenetic inference.