Reconstruction For The Next Generation

Through my day-to-day living, I saw a concerning development within our societal sphere. My concern is on a break among the generations that runs deeper than the normal trends of the younger generations being technologically savvy and the more mature generations talking about the "old days." We look at the greatest generation that faced the Great Depression as children then World War II as young adults. We look at the baby boomers as they ushered in an era of a strong work ethic and resourcefulness. The Gen X expanded technology. The millennials show their street smarts and are avid consumers. Then we see how the Gen Z develops their social media consumption habits and how they are always wired. This writing is to construct a new generation for looking forward to a change in our present-day generations. I hope my perspective will bring about some insight as to why we, as a generation, have been disconnected and why it is important to reconnect with all generations. The discussions here are the causes of the generational divide and some methods on how to bridge the gap among the generations. In the early stage of any writing, I examine how Martin Luther King Jr. sought to bridge the gap between the races to bring about a more perfect union. My goal is to bridge the generational gap to bring about a more harmonious people. Now is the time for us to evaluate and reevaluate our focus toward the goal of recovering our connection with all generations.

One of our preeminent historians of race and democracy argues that the period since 2008 has marked nothing less than America’s Third Reconstruction In The Third Reconstruction, distinguished historian Peniel E. Joseph offers a powerful and personal new interpretation of recent history. The racial reckoning that unfolded in 2020, he argues, marked the climax of a Third Reconstruction: a new struggle for citizenship and dignity for Black Americans, just as momentous as the movements that arose after the Civil War and during the civil rights era. Joseph draws revealing connections and insights across centuries as he traces this Third Reconstruction from the election of Barack Obama to the rise of Black Lives Matter to the failed assault on the Capitol. America’s first and second Reconstructions fell tragically short of their grand aims. Our Third Reconstruction offers a new chance to achieve Black dignity and citizenship at last—an opportunity to choose hope over fear.

Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applications This book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational challenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest work in leading labs actively contributing to the fast-growing field of NGS. The book is divided into four parts: Part I focuses on computing and experimental infrastructure for NGS analysis, including chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling strategies for massive viral sequencing, and high-fidelity sequencing protocols. Part II concentrates on analysis of DNA sequencing data, covering the classic scaffolding problem, detection of genomic variants, including insertions and deletions, and analysis of DNA methylation sequencing data. Part III is devoted to analysis of RNA-seq data. This part discusses algorithms and compares software tools for transcriptome assembly along with methods for detection of alternative splicing and tools for transcriptome quantification and differential expression analysis. Part IV explores computational tools for NGS applications in microbiomics, including a discussion on error correction of NGS reads from viral populations, methods for viral quasispecies reconstruction, and a survey of state-of-the-art methods and future trends in microbiome analysis. Computational Methods for Next Generation Sequencing Data Analysis: Reviews computational techniques such as new combinatorial optimization methods, data structures, high performance computing, machine learning, and inference algorithms Discusses the mathematical and computational challenges in NGS technologies Covers NGS error correction, de novo genome transcriptome assembly, variant detection from NGS reads, and more This text is a reference for biomedical professionals interested in expanding their knowledge of computational techniques for NGS data analysis. The book is also useful for graduate and post-graduate students in bioinformatics.

Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.

This book constitutes the refereed proceedings of the 6th International IFIP-TC6 Networking Conference, NETWORKING 2007, held in Atlanta, GA, USA in May 2007. The 99 revised full papers and 30 poster papers cover ad hoc and sensor networks, wireless networks, and the next generation internet.

Cheap and plentiful genome sequence data is transforming biology, and will surely transform systematics. This volume explores how.

Viruses are the most numerous and deadliest biological entities on the planet, infecting all types of living organisms—from bacteria to human beings. The constantly expanding repertoire of experimental approaches available to study viruses includes both low-throughput techniques, such as imaging and 3D structure determination, and modern OMICS technologies, such as genome sequencing, ribosomal profiling, and RNA structure probing. Bioinformatics of viruses faces significant challenges due to their seemingly unlimited diversity, unusual lifestyle, great variety of replication strategies, compact genome organization, and rapid rate of evolution. At the same time, it also has the potential to deliver decisive clues for developing vaccines and medications against dangerous viral outbreaks, such as the recent coronavirus pandemics. Virus Bioinformatics reviews state-of-the-art bioinformatics algorithms and recent advances in data analysis in virology. FEATURES Contributions from leading international experts in the field Discusses open questions and urgent needs Covers a broad spectrum of topics, including evolution, structure, and function of viruses, including coronaviruses The book will be of great interest to computational biologists wishing to venture into the rapidly advancing field of virus bioinformatics as well as to virologists interested in acquiring basic bioinformatics skills to support their wet lab work.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.