Regenerated Organs

Regenerated Organs: Future Perspectives provides the translational-research aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field. Discusses recent advances in tissue and organ fabrication Provides translational-research aspects that are often lacking in existing literature Contains chapters that are multi-authored by international experts in the field

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

This well-illustrated monograph is the first summary in English of L.V. Polezhaev's important but lesser known work on the regenerative phenomena in mammalian forms, conducted since World War II. During this period Soviet research underwent a pronounced shift in emphasis from basic biological studies based primarily upon amphibians to more practically oriented problems in mammalian systems. Polezhaev's experimentation underwent a corresponding shift, but the focus on restoration of lost regenerative capacity was retained since his earlier work, which is also reviewed here, on limb regeneration in frogs. Following a theoretical discussion, the monograph centers upon the author's most profound innovations: a successful method for producing bone to heal large skull defects, original research on heart regeneration, and trials in the restoration of limb regeneration following X-irradiation.

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Biointegration is essential for the successful performance of implanted materials and devices within the human body. With an increasing number and wide range of implant procedures being performed, it is critical that materials scientists and engineers effectively design implant materials which will create a positive biological and mechanical response with the host tissue. Biointegration of medical implant materials provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration. Part one discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering and vascular grafts. Part two then reviews particular techniques in drug delivery including inorganic nanoparticles for targeted drug delivery and alginate based drug delivery devices. Part three covers design considerations with coverage of themes such as biocompatibility of materials and its relevance to drug delivery and tissue engineering, mechanisms of failure of medical implants during long term use and rapid prototyping in biomedical engineering. With its distinguished editor and team of international contributors, Biointegration of medical implant materials: science and design is a standard reference for medical materials scientists and engineers in industry and the academic sector. Provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration Discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering, vascular grafts and replacement materials for facial reconstruction Reviews particular techniques in drug delivery featuring inorganic nanoparticles and functionalized nanoparticles for targeted drug delivery