Research Priorities For Zoonoses And Marginalized Infections

This report provides a review and analysis of the research landscape for zoonoses and marginalized infections which affect poor populations, and a list of research priorities to support disease control. The work is the output of the disease reference group on zoonoses and marginalized infectious diseases (DRG6), which is part of an independent think tank of international experts, established and funded by the Special Programme for Research and Training in Tropical Diseases (TDR), to identify key research priorities through the review of research evidence and input from stakeholder consultations. The report covers a diverse range of diseases including zoonotic helminth protozoa, viral and bacterial infections considered to be neglected and associated with poverty. Disease-specific research issues were elaborated under individual disease sections and many common priorities were readily identified among the disease such as need for new and/or improved drugs and regimens, diagnostics and, where appropriate, vaccines. The disease specific priorities are described as micro priorities compared with the macro level priorities which will drive such policies as the need for improved surveillance; the need for inter-sectoral interaction between health, livestock, agriculture, natural resources and wildlife in tackling the zoonotic diseases; and the need for a true assessment of the burden of the zoonoses. This is one of ten disease and thematic reference group reports that have come out of the TDR Think Tank, all of which have contributed to the development of the Global Report for Research on Infectious Diseases of Poverty.

This report provides a review and analysis of the research landscape for zoonoses and marginalized infections which affect poor populations, and a list of research priorities to support disease control. The work is the output of the disease reference group on zoonoses and marginalized infectious diseases (DRG6), which is part of an independent think tank of international experts, established and funded by the Special Programme for Research and Training in Tropical Diseases (TDR), to identify key research priorities through the review of research evidence and input from stakeholder consultations. The report covers a diverse range of diseases including zoonotic helminth protozoa, viral and bacterial infections considered to be neglected and associated with poverty. Disease-specific research issues were elaborated under individual disease sections and many common priorities were readily identified among the disease such as need for new and/or improved drugs and regimens, diagnostics and, where appropriate, vaccines. The disease specific priorities are described as micro priorities compared with the macro level priorities which will drive such policies as the need for improved surveillance; the need for inter-sectoral interaction between health, livestock, agriculture, natural resources and wildlife in tackling the zoonotic diseases; and the need for a true assessment of the burden of the zoonoses. This is one of ten disease and thematic reference group reports that have come out of the TDR Think Tank, all of which have contributed to the development of the Global Report for Research on Infectious Diseases of Poverty.

The Thematic Reference Group on Environment, Agriculture and Infectious Diseases of Poverty (TRG 4) addresses the nature of the intersections and interactions between environment, agriculture and infectious diseases of poverty in order to identify research priorities for improved disease control. This report reviews the connections between environmental change, modern agricultural practices and the occurrence of infectious diseases--especially those of poverty--and proposes a methodology that can be used to prioritize research on such diseases. Although there is some comprehension of the underlying and growing systemic influence of today s large-scale social and environmental changes on some infectious diseases, the significance and potential future impacts of these changes are poorly understood. Nevertheless, such changes now constitute a significant influence on the working of the Earth's systems that will have increasing consequences for patterns of occurrence of infectious diseases. Many of these changes are illustrated in this report. A common theme of this report is bidirectional causation, effectively "trapping" complex, linked eco-social systems in stable states that are resistant to intervention. For example, poverty is associated with ill health, low education and often with poor diets, either because of under-nutrition (and diarrhoea) or intakes that have excessive calories but insufficient micronutrients. In either case, poverty impairs health; and ill health impairs the escape from poverty. Another example is provided by a recent abundant agricultural harvest in India that has far exceeded storage capacity. A substantial fraction of this harvest will be wasted due to inadequate storage. Some grain that is badly stored will be contaminated by aflatoxins and other fungi, which increases the risk of cancer. This report presents the case for a more integrated approach across sectors, research disciplines and diseases, taking greater account of the increasingly widespread and systemic influences on disease emergence and spread.

This second fully revised and extended edition of “Zoonoses - Infections Affecting Humans and Animals” covers the most important pathogens impacting both human and animal public health and debates current developments in this interdisciplinary field from a One Health perspective. Following a "setting" approach, the individual chapters each review zoonoses occurring in a specific group of animals, such as production animals, pets or wildlife, or in a defined ecosystem. A focus is put on zoonoses emerging along the food chain and on antibiotic resistance as an increasing challenge in infectious disease management. Special interest chapters debate non-resolved and currently hotly debated zoonoses, foremost COVID-19, influenza, Crohn/paratuberculosis and chronic botulism, also taking into account the economic and ecological aspects of zoonotic disease outbreaks. This second edition includes brand-new chapters on emerging pathogens such as SARS-CoV-2, chlamydia and helminths, it reviews historic zoonoses, provides additional insights into pathogens of reptiles and highlights significant neglected tropical diseases. This reference work is a must-read for researchers, health professionals and students in Microbiology and Veterinary Medicine. The book’s ambition to spread knowledge on zoonoses and on strategies on how to tackle them complies with the United Nations Sustainable Goals, in particular Goal 3 – Good Health and Well-Being.

Global public health is of growing concern to most governments and populations, nowhere more so than in Asia, the world’s largest and most populous continent. Whilst major advances have been made in controlling infectious diseases through public health measures as well as clinical medical treatments, the world now faces other challenges including ageing populations and the epidemic crisis of obesity and non-communicable diseases. New emerging infections continue to develop and the growing threats to health due to environmental pollution and climate change increase the need for resilience and sustainability. These threats to health are global in nature, and this Handbook will explore perspectives on current public health issues in South, Southeast and East Asia, informing global as well as regional debate. Whilst many books cite Western examples of the development of global public health, this Handbook brings together both Western and Eastern scholarship, creating a new global public health perspective suitable to face modern challenges in promoting the population’s health. This Handbook is essential reading not only for students, professionals and scholars of global public health and related fields but is also written to be accessible to those with a general interest in the health of Asia.

This book provides updated information on helminth infections, with proposals for new treatments and biological factors of risk, the development of vaccines for the control of helminthiasis and explains the latest research on the field. It also delves into multi-omics, diagnosis, immunology, and novel molecule targets. In addition, the book examines topics such as host-parasite interaction. Key Features: • Provides basic and clinical evidence based on molecular interactions to address the risks and benefits of helminthiasis • Presents the results of new vaccine development • Discusses new and old therapeutic approaches in helminth infections • Delves into advances in the molecular and immune response in helminth infection • Proposes a One Health approach to study helminth infections • Analyzes the controversies and confusions in the management, biology, and control strategies of helminth infections • Examines the basic biology of helminth parasites

This textbook, which is the first volume in the series Microbial Zoonoses, provides a comprehensive overview of the diagnosis, treatment and control of zoonotic parasitic diseases. The book is divided into two sections; the first section discusses the classification of parasitic zoonoses and includes general information on the diagnosis, treatment, epidemiology, prevention, and control of parasitic zoonoses. It also describes the biological features of these organisms, host-parasite interactions, and the disease spectrum, as well as the importance of public health control measures, such as surveillance, and prophylactic measures in controlling these diseases.The second section explores the important zoonotic diseases caused by ectoparasites, protozoan and helminths parasites. It also reviews the life cycle, pathogenesis, pathology, immunology and clinical manifestations, modern diagnostic methods, treatment regimen, prevention, control, and epidemiology of these parasites.Cutting across the disciplines, this book serves as a guide to postgraduate students, faculty members, public health experts, and medical administrators who are interested in the management of these parasitic zoonotic infections.