Retinal And Optic Nerve Stem Cell Surgery

This is a concise how-to of successfully treating previously deemed "untreatable" retinal and optic nerve conditions with stem cell therapies. Based on the results of 11 years of experience treating approximately 600 patients, this text will serve as a template for others to develop similar stem cell based treatments in their specialty. Author, Jeffrey N. Weiss, MD is specifically poised to offer dependable insight on stem cell surgery for both the retina and the optic nerve, having performed the first retinal stem cell surgery in 2010, with Institutional Review Board (IRB) approved studies that are registered with the National Institute of Health (NIH), and listed on ClinicalTrials.gov. Featuring all original work from Dr. Jeffrey Weiss's specialization in stem cell ophthalmology, this book is primarily written for ophthalmologists, but structured so that specialists across disciplines can take the model presented and create their own studies and clinical trials using stem cell therapies.

The book was written to educate and guide patients wishing to learn about retinal and optic nerve stem cell surgery.

This is a concise how-to of successfully treating previously poorly or untreatable neurologic conditions with stem cell therapies. The text examines the IRB approved protocols of NEST (Neurologic Bone Marrow Derived Stem Cell Treatment Study), SCiExVr (Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study), and ACIST (Alzheimer’s and Cognitive Impairment Stem Cell Treatment Study). The discussion focuses on the protocols and informed consents and may be used as a template for specialists to develop clinical trials utilizing stem cell based therapy. Other potential noninvasive treatments for brain injury are also discussed. Neurologic Stem Cell Surgery, the sister text to the recently published Retinal and Optic Nerve Stem Cell Surgery, is an invaluable reference for all physicians with an interest in the development of stem cell based treatments.

This book is a compendium of the worldwide ocular stem cell, gene therapy, and other studies treating Optic Nerve Disease that are registered with Clinicaltrials.gov. The study and the Clinical Trial number is provided in order to make it easier for the reader to obtain further information. The book contains an introduction to Optic Nerve Disease as well as a summary of common optic nerve conditions. Clinical Trials in Optic Nerve Disease Treatment is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.

This book is a concise guide that provides an easy to follow template for other physicians to develop similar stem cell based treatments within their specialty. It identifies and summarizes the current world-wide orthopedic stem cell trials. Organized into three sections, Orthopedic Stem Cell Surgery presents clinical studies that examine the procedures for setting up and implementing stem cell surgery within the specialty of orthopedics. Chapters maintain an accessible narrative while also addressing complex studies related to orthopedic stem cell surgery. A sister text to the recently published, Retinal and Optic Nerve Stem Cell Surgery, and Neurologic Stem Cell Surgery this expertly written book examines critical Institutional Review Board (IRB) approved studies.

In this volume, some of the leading authorities present their exploration of applications of stem cell therapy to the treatment of major causes of blindness, including degenerative diseases and glaucoma. The diagnostic approach to patients, general concepts of cell-based therapy, immunological considerations, approaches to cell delivery (including engineered scaffolds), combined cell and gene therapy, nanomedicine applications to cell therapy and regulatory issues pertaining to manufacture and production are all considered in detail. The book serves as an excellent introduction to a field that is now entering early-stage clinical trials and promises to operate at the leading edge of regenerative medicine. Retina specialists, general ophthalmologists as well as researchers will find here a wealth of information on the translational aspects of cell-based therapies. Further, business executives and students interested in understanding the potential applications of stem cell therapy to retinal degenerative disease and glaucoma will also find this book informative reading.

This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.

This book is a compendium of the worldwide ocular stem cell studies registered with clinicaltrials.gov. The study title is provided, along with the country of origin and the clinical trial number in order to make it easier for the reader to locate the study and obtain further information. An analysis of the type of stem cell utilized and study support is also provided. The final section deals with issues encountered by the stem cell researchers. Ocular Stem Cell Studies: A Comprehensive Overview of Global Clinical Trials is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.