Robotic Radiosurgery

With contributions by numerous experts

Covers a wide range of topics on robotic radiosurgery. General topics on robotic radiosurgery include: 9 chapters on history, physics, radiobiology and technology and 24 chapters on CNS, non-CNS and future applications in robotic radiosurgery. Includes 157 figures and 93 tables,

Harold C. Urschel, Jr. (Editor-in-Chief) John J. Kresl · James D. Luketich Lech Papiez ·Robert D. Timmerman (Co-Editors) Raymond A. Schulz (Contributing Editor) Treating Tumors that Move with Respiration With Contributions by Numerous Experts Foreword by E. Thomson With 116 Figures in 168 Separate Illustrations, 120 in Color and 31 Tables 123 IV Foreword Editor-in-Chief: James D. Luketich, MD Sampson Family Endowed Professor of Surgery Harold C. Urschel Jr. , MD Chief, The Heart, Lung and Chair of Cardiovascular and Thoracic Surgical Esophageal Surgery Institute Research, Education and Clinical Excellence University of Pittsburgh Medical Center, PUH, C-800 Baylor University Medical Center 200 Lothrop Street 1201 Barnett Tower Pittsburgh, PA 15213 3600 Gaston Avenue USA Dallas, TX 75246 USA Lech Papiez, PhD Associate Professor Department of Radiation Oncology University of Texas Southwestern Medical Center 5801 Forest Park Road Dallas, TX 75390 Co-Editors: USA John J. Kresl, MD, PhD Arizona Oncology Services at Robert D. Timmerman, MD St. Joseph’s Hospital & Medical Center Professor and Vice-Chairman Department of Radiation Oncology Ef? e Marie Cain Distinguished Chair in CyberKnife Center Cancer Therapy Research Barrow Neurological Institute Department of Radiation Oncology Gamma Knife Center University of Texas Southwestern Medical Center 350 West Thomas Road 5801 Forest Park Road Phoenix, Arizona 85013 Dallas, TX 75390 USA USA Library of Congress Control Number: 2007920177 ISBN 978-3-540-69885-2 Springer Berlin Heidelberg New York This work is subject to copyright.

The treatment of prostate cancer continues to be problematic owing to serious side-effects, including erectile dysfunction and urinary incontinence. Robotic radiosurgery offers a novel, rapid, non-invasive outpatient treatment option that combines robotics, advanced image-guided spatial positioning, and motion detection with submillimeter precision. This book examines all aspects of the treatment of prostate cancer with robotic radiosurgery. It explains how image-guided robotic radiosurgery overcomes the problem of patient motion during radiation therapy by continuously identifying the precise location of the prostate tumor throughout the course of treatment. Hypofractionated radiation delivery by means of robotic radiosurgery systems is also discussed in detail. The book closes by examining other emerging genitourinary applications of robotic radiosurgery. All of the authors are experts in their field who present a persuasive case for this fascinating technique.

The treatment of prostate cancer continues to be problematic owing to serious side-effects, including erectile dysfunction and urinary incontinence. Robotic radiosurgery offers a novel, rapid, non-invasive outpatient treatment option that combines robotics, advanced image-guided spatial positioning, and motion detection with submillimeter precision. This book examines all aspects of the treatment of prostate cancer with robotic radiosurgery. It explains how image-guided robotic radiosurgery overcomes the problem of patient motion during radiation therapy by continuously identifying the precise location of the prostate tumor throughout the course of treatment. Hypofractionated radiation delivery by means of robotic radiosurgery systems is also discussed in detail. The book closes by examining other emerging genitourinary applications of robotic radiosurgery. All of the authors are experts in their field who present a persuasive case for this fascinating technique.

Harold C. Urschel, Jr. (Editor-in-Chief) John J. Kresl · James D. Luketich Lech Papiez ·Robert D. Timmerman (Co-Editors) Raymond A. Schulz (Contributing Editor) Treating Tumors that Move with Respiration With Contributions by Numerous Experts Foreword by E. Thomson With 116 Figures in 168 Separate Illustrations, 120 in Color and 31 Tables 123 IV Foreword Editor-in-Chief: James D. Luketich, MD Sampson Family Endowed Professor of Surgery Harold C. Urschel Jr. , MD Chief, The Heart, Lung and Chair of Cardiovascular and Thoracic Surgical Esophageal Surgery Institute Research, Education and Clinical Excellence University of Pittsburgh Medical Center, PUH, C-800 Baylor University Medical Center 200 Lothrop Street 1201 Barnett Tower Pittsburgh, PA 15213 3600 Gaston Avenue USA Dallas, TX 75246 USA Lech Papiez, PhD Associate Professor Department of Radiation Oncology University of Texas Southwestern Medical Center 5801 Forest Park Road Dallas, TX 75390 Co-Editors: USA John J. Kresl, MD, PhD Arizona Oncology Services at Robert D. Timmerman, MD St. Joseph’s Hospital & Medical Center Professor and Vice-Chairman Department of Radiation Oncology Ef? e Marie Cain Distinguished Chair in CyberKnife Center Cancer Therapy Research Barrow Neurological Institute Department of Radiation Oncology Gamma Knife Center University of Texas Southwestern Medical Center 350 West Thomas Road 5801 Forest Park Road Phoenix, Arizona 85013 Dallas, TX 75390 USA USA Library of Congress Control Number: 2007920177 ISBN 978-3-540-69885-2 Springer Berlin Heidelberg New York This work is subject to copyright.

Lung cancer, which was rare at the beginning of the 20th century, is now a major cause of cancer-related deaths in men and women. It is the most frequently diagnosed cancer in the world. With conventional radiation therapy, small doses of radiation are delivered on a daily Monday-to-Friday schedule over a period of approximately a month and a half. After receiving this therapy, some reversible side effects, such as local skin irritation, are common. Robotic stereotactic radiotherapy is based on the principle of delivering high doses of radiation to the tumor while sparing or avoiding the surrounding tissues, which has been one of the greatest limiting factors of conventional radiation therapy historically. Given the advancements in technology, the reproducibility of patient positioning and the capability to deliver radiation from hundreds of different directions while synchronizing respiration-induced target motion, this technology is now proposed as a new local treatment, completed in less than one week, with promising results.

Compensating for Quasi-periodic Motion in Robotic Radiosurgery outlines the techniques needed to accurately track and compensate for respiratory and pulsatory motion during robotic radiosurgery. The algorithms presented within the book aid in the treatment of tumors that move during respiration. In Chapters 1 and 2, the book introduces the concept of stereotactic body radiation therapy, motion compensation strategies and the clinical state-of-the-art. In Chapters 3 through 5, the author describes and evaluates new methods for motion prediction, for correlating external motion to internal organ motion, and for the evaluation of these algorithms’ output based on an unprecedented amount of real clinical data. Finally, Chapter 6 provides a brief introduction into currently investigated, open questions and further fields of research. Compensating for Quasi-periodic Motion in Robotic Radiosurgery targets researchers working in the related fields of surgical oncology, artificial intelligence, robotics and more. Advanced-level students will also find this book valuable.