Sex Steroids

Research on health involves evaluating the disparities that are systematically associated with the experience of risk, including genetic and physiological variation, environmental exposure to poor nutrition and disease, and social marginalization. This volume provides a unique perspective - a comparative approach to the analysis of health disparities and human adaptability - and specifically focuses on the pathways that lead to unequal health outcomes. From an explicitly anthropological perspective situated in the practice and theory of biosocial studies, this book combines theoretical rigor with more applied and practice-oriented approaches and critically examines infectious and chronic diseases, reproduction, and nutrition.

It is the object of this series of monographs to present the experiments and interpre tations of a given laboratory. We have attempted in this volume to present our view of receptor-steroid interactions and their relation to steroid-induced responses. This view is necessarily biased by our own experimental results. While we have tried to in clude the views and results of others, this volume is not meant to be comprehensive. Rather it is selective and examines those topics within the general field of steroid hor mone action which we have addressed at the laboratory bench. The work reviewed in this volume would not exist without the help and support of many associates. Our mentors included Jorge Awapara, Jack Gorski, Henry Komer, Bill Ray, and Mike Zarrow. Associates instrumental in this work include George Barr, John Burgner, Sam Campbell, Constance Cardasis, Hitkan Eriksson, Stan Glasser, Jim Hardin, Mohammed Kalimi, Bruce Lester, Barry Markavarich, Shirley McCormick, Tony Means, Dan Medina, Ann Miller, Bert O'Malley, Helen Padyku la, Zigmund Paszko, Dale Snow, Susan Upchurch and Marian Walters. Students who have contributed to this effort include John Anderson, Joe DeLibero, Aaron Hsueh, Katrina Kelner, Debbie Metzger, Randy Richards, Jim Schaeffer, Mike Tytell, Lane von Brunt, and Cheryl Watson. Technicians without whose assistance this work could not exist include Toni Cetti, Wendy D'Attilio, Jeanie Haselby, Lily Hsueh, Helen Hyland, Jim Kovar, Kathy O'Connor, and Peggy Sansone."

Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. The proceedings provide new insights and concepts gained by molecular, cellular and neuroendocrine research into mechanistic interactions of the reproductive and somatotrophic axes. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; sex steroids, growth hormone releasing factor, and somatostatin; how sex steroids modulate growth hormone action on target issues; and differential effects of growth hormone secretagogues in men and women. This volume is designed for physicians, scientists and other health professionals interested or trained in clinical and basic endocrinology, growth or reproduction.

This book analyzes the effects of estrogens and progesterone on brain cells, the immune system, neuro inflammation, myelin formation and steroid receptor distribution, as well as their clinical impacts. It also explores the relationship between sex-steroid withdrawal and the development of brain symptoms such as hot flushes, sleep disorders, mood changes, depression and also cognitive disorders and dementia, as well as the effects of hormone menopause therapy on such symptoms and diseases. Starting with obstetrical history and cardiovascular risk in later life, the second part of the book examines the effects of estrogens and progestogens on vascular tissues, atherosclerosis and coronary heart diseases, as well as the impact of hormone replacement therapies on cardiovascular risks and mortality. This volume is a useful, clear and up-to-date tool for gynecologists, endocrinologists, neurologists and cardiologists, and serves as a valuable source of information for all physicians involved in women’s health.

Prominent clinicians and researchers from diverse disciplines discuss the basic cell and molecular biology of steroid action and sex steroids' effects on the nervous and immune systems. Provides an integrated evaluation of the advantages and disadvantages of hormone replacement therapy.

We inherit mechanisms for survival from our primeval past; none so obviously as those involved in reproduction. The hormone testosterone underlies the organization of activation of masculinity: it changes the body and brain to make a male. It is involved not only in sexuality but in driving aggression, competitiveness, risk-taking - all elements that were needed for successful survival and reproduction in the past. But these ancient systems are carried forward into a modern world. The ancient world shaped the human brain, but the modern world is shaped by that brain. How does this world, with all its cultural, political, and social variations, deal with and control the primeval role of testosterone, which continues to be essential for the survival of the species? Sex, aggression, winning, losing, gangs, war: the powerful effects of testosterone are entwined with them all. These are the ingredients of human history, so testosterone has played a central role in our story. In Testosterone, Joe Herbert explains the nature of this potent hormone, how it operates in mammals in general and in humans in particular, what we know about its role in influencing various aspects of behaviour in men, and what we are beginning to understand of its role in women. From rape to gang warfare among youths, understanding the workings of testosterone is critical to enable us to manage its continuing powerful effects in modern society.

Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. The proceedings provide new insights and concepts gained by molecular, cellular and neuroendocrine research into mechanistic interactions of the reproductive and somatotrophic axes. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; sex steroids, growth hormone releasing factor, and somatostatin; how sex steroids modulate growth hormone action on target issues; and differential effects of growth hormone secretagogues in men and women. This volume is designed for physicians, scientists and other health professionals interested or trained in clinical and basic endocrinology, growth or reproduction.