Small Molecule Dna And Rna Binders

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.

The field of materials science and technology has undergone revolutionary advances due to the development of novel analytical tools, functional materials, and multidisciplinary approaches to engineering. Additionally, theoretical predictions combined with increasingly improved models and computational capabilities are making impressive contribution

with contributions by numerous experts

The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.

This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.