Statin Associated Muscle Symptoms

This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.

The Essential Guide to Recognizing and Treating Acute Endocrine and Metabolic Illness Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. Endocrine and Metabolic Medical Emergencies: A Clinician’s Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. Already the definitive and most comprehensive guide to endocrine emergency care, this new second edition: provides acute care guidance for a range of both common and unusual endocrine emergencies; details the effects of acute medical and critical illness on metabolic and endocrine systems, and their impacts on endocrine investigations; discusses special patient populations, including the impacts of aging, pregnancy, transplantation, late-effects, perioperative, inherited metabolic disorders and HIV/AIDS on presentation and management; and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more. Packed with case studies, images, and chapters written by distinguished authors, this guide is designed for both quick reference and study. Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more. Blending the latest science with clinical and practical advice, this invaluable resource helps clinicians stay up to date with the field’s relevant body of knowledge while providing the practical, clinical insight they need in order to provide their patients with the utmost level of care.

In this newly updated and re-edited 2012 edition, the side effects of cholesterol lowering statins are thoroughly assessed. Also reviewed are dietary and supplement choices that may offer benefit in the prevention of heart disease and in combating and preventing statin damage. The cholesterol lowering drugs known as statins are of proven benefit for some groups of people for the prevention of heart attacks and stroke, but statins also have a dark side. Tens of thousands of people have been victims of a huge array of statin drugs side effects, ranging from permanent cognitive dysfunction and severe personality change to disabilities from permanent peripheral neuropathy, permanent myopathy and chronic muscular degeneration. It has recently been reported that muscle pain cases frequently become permanent and many neurologists now regard statin neuropathy as predictably resistant to traditional treatment. When statins were first marketed there was seemingly no awareness of possible mitochondrial DNA effect or the importance of glial cell cholesterol to cognitive function and little or no concern that to inhibit cholesterol means to interrupt its pathway shared by both CoQ10 and dolichols and many other vital substances. Nor was it known that statins are powerful anti-inflammatory agents, the fundamental reason for their benefit in cardiovascular risk. The outmoded concept of looking at cholesterol numbers as a predictor of cardiovascular risk is increasingly being dismissed as studies point to cholesterol levels as being seemingly irrelevant to the process of atherosclerosis. In addition to the crisis of thousands of people disabled by statin associated neuro-muscular problems is the fact that many physicians still remain unaware that statins can even do this. Then there is the crisis of the growing trend of the insurance industry to use cholesterol levels as a reason to deny health care coverage or life insurance coverage. Some employers even require cholesterol levels to be below a certain number as a condition of employment. Plus the crisis of patients being forced into taking a statin because not to do so would result in having to find a new doctor. The Statin Damage Crisis looks at how statins work, the importance of cholesterol in the body, inflammation and atherosclerosis, anti-inflammatory alternatives to statins, serious side effects of statins, and dietary supplements of possible benefit to those taking statins or that were forced to stop taking a statin due to unpleasant and even disabling side effects.

'The Oxford Textbook of Neuromuscular Disorders' covers the scientific basis, clinical diagnosis, and treatment of neuromuscular disorders, with a particular focus on the most clinically relevant disorders

A key text for all those involved in pharmacovigilance. Detection of new adverse drug reactions is fundamental to the protection of patients from harm that may occur as a result of medication. This book explores the methods used to investigate new adverse drug reactions, discussing all elements from the scientific background and animal toxicology through to worldwide regulatory and ethical issues. Stephens' Detection of New Adverse Drug Reactions provides comprehensive and up-to-date coverage of material fundamentally important to all those active in the field, whether they work in the pharmaceutical industry, drug regulatory authorities or in academia. The fifth edition of this classic reference work includes new chapters on: vaccine safety surveillance managing drug safety issues with marketed products operational aspects of drug safety function safety of biotechnology products future of pharmacovigilance Reviews of previous editions: "This book surpasses all its educational aims. Not only is the subject matter covered comprehensively but the material is presented in a very user-friendly manner. The editors have succeeded in producing a highly-specific, definitive reference book which doubles as a most enjoyable read." —Commended by the 1999 BMA Medical Book Competition "For anyone entering the field of adverse reaction monitoring one could not wish for a better primer" —International Journal of Risk and Safety in Medicine

Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria