Statin Associated Muscle Symptoms

This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.

The Essential Guide to Recognizing and Treating Acute Endocrine and Metabolic Illness Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. Endocrine and Metabolic Medical Emergencies: A Clinician’s Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. Already the definitive and most comprehensive guide to endocrine emergency care, this new second edition: provides acute care guidance for a range of both common and unusual endocrine emergencies; details the effects of acute medical and critical illness on metabolic and endocrine systems, and their impacts on endocrine investigations; discusses special patient populations, including the impacts of aging, pregnancy, transplantation, late-effects, perioperative, inherited metabolic disorders and HIV/AIDS on presentation and management; and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more. Packed with case studies, images, and chapters written by distinguished authors, this guide is designed for both quick reference and study. Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more. Blending the latest science with clinical and practical advice, this invaluable resource helps clinicians stay up to date with the field’s relevant body of knowledge while providing the practical, clinical insight they need in order to provide their patients with the utmost level of care.

Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

'The Oxford Textbook of Neuromuscular Disorders' covers the scientific basis, clinical diagnosis, and treatment of neuromuscular disorders, with a particular focus on the most clinically relevant disorders

In this newly updated and re-edited 2012 edition, the side effects of cholesterol lowering statins are thoroughly assessed. Also reviewed are dietary and supplement choices that may offer benefit in the prevention of heart disease and in combating and preventing statin damage. The cholesterol lowering drugs known as statins are of proven benefit for some groups of people for the prevention of heart attacks and stroke, but statins also have a dark side. Tens of thousands of people have been victims of a huge array of statin drugs side effects, ranging from permanent cognitive dysfunction and severe personality change to disabilities from permanent peripheral neuropathy, permanent myopathy and chronic muscular degeneration. It has recently been reported that muscle pain cases frequently become permanent and many neurologists now regard statin neuropathy as predictably resistant to traditional treatment. When statins were first marketed there was seemingly no awareness of possible mitochondrial DNA effect or the importance of glial cell cholesterol to cognitive function and little or no concern that to inhibit cholesterol means to interrupt its pathway shared by both CoQ10 and dolichols and many other vital substances. Nor was it known that statins are powerful anti-inflammatory agents, the fundamental reason for their benefit in cardiovascular risk. The outmoded concept of looking at cholesterol numbers as a predictor of cardiovascular risk is increasingly being dismissed as studies point to cholesterol levels as being seemingly irrelevant to the process of atherosclerosis. In addition to the crisis of thousands of people disabled by statin associated neuro-muscular problems is the fact that many physicians still remain unaware that statins can even do this. Then there is the crisis of the growing trend of the insurance industry to use cholesterol levels as a reason to deny health care coverage or life insurance coverage. Some employers even require cholesterol levels to be below a certain number as a condition of employment. Plus the crisis of patients being forced into taking a statin because not to do so would result in having to find a new doctor. The Statin Damage Crisis looks at how statins work, the importance of cholesterol in the body, inflammation and atherosclerosis, anti-inflammatory alternatives to statins, serious side effects of statins, and dietary supplements of possible benefit to those taking statins or that were forced to stop taking a statin due to unpleasant and even disabling side effects.

This short handbook summarises the clinical features, epidemiology, current treatment paradigms, and ongoing trials for the idiopathic inflammatory myopathies (IMM). Aimed at both trainees and physicians with an aim to improving the quality of care for people with IMM

The first real cases video atlas of neuromuscular disorders that is supplemented with multiple-choice questions, and updates on the illustrated topics. It is easy to search and read. It is perfect for preparation to the neurology and neuromuscular boards and an excellent way to update the experts. By replacing the descriptive text with vivid illustrative videos, the reader will have more time to face the intellectual challenges of these cases instead of trying to build a mental picture of these cases first. Short and well-edited video clips from real clinic stories supplemented with challenging multiple choice questions, provides an excellent way to bridge the gap between overflow of information and short attention span. The chapters are arranged according the symptoms instead of diseases, yet, diseases are listed in the index if one wants to see all videos relevant to a specific disease. Close to 300 video cases* taken directly from a real neuromuscular clinic, illustrating a myriad of disorders and shedding light on their diagnosis, and treatment and giving updates about many of them provides an invaluable approach that should benefit any one who is interested in neuromuscular disorders which comprises more than 50% of presenting disease to general neurologists and even to general practitioners. Some rare diseases are also described, giving an opportunity for the new trainees to see them so that they can diagnosed them if they see them again which may not happen very often. *Due to size limitations, the videos are not included with any eBook version.