Stimulation Of Fracture Healing With Ultrasound

Every bone fracture must be held rigid and, because of the long healing process, infringes on the individual's life-style. Treatment with ultrasound, however, may reduce the healing time 30-50% since the piezoelectric effect of ultrasound acts as a callus stimulator. This book documents more than twenty years of clinical experience with ultrasound treatment of fractures. The authors give statistical evidence and show numerous X-rays to document their success. They also include a summary of experimental studies. The method is described in detail so that the practicing physician can easily learn how to apply it.

This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.

Evidence-Based Orthopedics is an up-to-date review of the best evidence for the diagnosis, management, and treatment of orthopedic conditions. Covering orthopedic surgery as well as pre- and post-operative complications, this comprehensive guide provides recommendations for implementing evidence-based practice in the clinical setting. Chapters written by leading clinicians and researchers in the field are supported by tables of evidence that summarize systematic reviews and randomized controlled trials. In areas where evidence is insufficient to recommend a practice, summaries of the available research are provided to assist in decision-making. This fully revised new edition reflects the most recent evidence using the approved evidence-based medicine (EBM) guidelines and methodology. The text now places greater emphasis on GRADE—a transparent framework for developing and presenting summaries of evidence—to allow readers to easily evaluate the quality of evidence and the strength of recommendations. The second edition offers a streamlined presentation and an improved standardized format emphasizing how evidence in each chapter directly affects clinical decisions. Incorporating a vast amount of new evidence, Evidence-Based Orthopedics: Features thoroughly revised and updated content, including a new chapter on pediatric orthopedics and new X-ray images Provides the evidence base for orthopedic surgery as well as pediatric orthopedics and orthopedic conditions requiring medical treatment Covers the different methods for most orthopedic surgical procedures, such as hip replacements, arthroscopy, and knee replacements Helps surgeons and orthopedic specialists achieve a uniform optimum standard through a condition-based approach Aligns with internationally accepted guidelines and best health economic principles Evidence-Based Orthopedics is an invaluable resource for orthopedic specialists, surgeons, trauma surgeons, trainees, and medical students.

Many significant achievements in new ultrasound technologies to measure bone and models to elucidate the interaction and the propagation of ultrasonic waves in complex bone structures have been reported over the past ten years. Impaired bone remodeling affects not only the trabecular compartment but also the cortical one. Despite the crucial contribution of the cortical structure to the whole bone mechanical competence, cortical bone was understudied for a long time. A paradigm shift occurred around 2010, with a special focus placed on the importance of cortical bone. This has sparkled a great deal of interest in new ultrasound techniques to assess cortical bone. While our book ‘Bone Quantitative Ultrasound’ published in 2011 emphasized techniques to measure trabecular bone, this new book is devoted for a large part to the technologies introduced recently to measure cortical bone. These include resonant ultrasound spectroscopy, guided waves, scattering, and pulse-echo and tomography imaging techniques. Instrumentation, signal processing techniques and models used are detailed. Importantly, the data accumulated in recent years such as anisotropic stiffness, elastic engineering moduli, compression and shear wave speeds of cortical bones from various skeletal sites are presented comprehensively. A few chapters deal with the recent developments achieved in quantitative ultrasound of trabecular bone. These include (i) scattering-based approaches and their application to measure skeletal sites such as the spine and proximal femur and (ii) approaches exploiting the poro-elastic nature of bone. While bone fragility and osteoporosis are still the main motivation for developing bone QUS, this Book also includes chapters reporting ultrasound techniques developed for other applications of high interest such as 3-D imaging of the spine, assessment of implant stability and transcranial brain imaging. This book, together with the book ‘Bone Quantitative Ultrasound’ published in 2011 will provide a comprehensive overview of the methods and principles used in bone quantitative ultrasound and will be a benchmark for all novice or experienced researchers in the field. The book will offer recent experimental results and theoretical concepts developed so far and would be intended for researchers, graduate or undergraduate students, engineers, and clinicians who are involved in the field. The book should be considered as a complement to the first book publisher in 2011, rather than a second edition, in the sense that basic notions already presented in the first book are not repeated.

This comprehensive reference work provides a detailed overview of shockwave therapy, a relatively new clinical specialty in modern medicine. It follows the evolution of Extracorporeal Shockwave Therapy (ESWT) from its initial stage as the gold standard for the disintegration of kidney stones to its regenerative effects in biological tissues. Starting with the basic principles of shockwave treatment, the book goes on to review its application in musculoskeletal disorders, including osteonecrosis of the hip, tendinopathy, fracture treatment, and treatment of sports related injuries. The application of ESWT in cardiovascular diseases is discussed. This includes preclinical and clinical applications for ischemic cardiovascular disease and effects on angiogenesis and anti-inflammation-molecular-cellular signaling pathways. The treatment of urinary diseases and erectile dysfunction by ESWT is elaborated. The book concludes with a discussion of future prospects of the shockwave therapy. Scholars and research fellows interested in shockwave medicine will benefit greatly from this work. It is also a useful clinical resource for nephrologists, urologists, cardiologists, and orthopedists.

Bone is a complex and specialised connective tissue, with a degree of elasticity even with a high concentration of mineralised components in the extracellular space. After a fracture event, an acute response takes place with a molecular signalling cascade for bone induction, called fracture healing. This phenomenon represents a multistage repair process with a well defined temporal and spatial sequence, and it can lead to severe complications such as non-unions, delayed unions, and infections, whose treatment represents important negative consequences for patients and a socio-economic burden, particularly due to the high costs in health care. Besides the conventional X-rays and more recently computed tomography, ultrasound techniques have been proposed to evaluate and monitor fracture regeneration. On the other hand, recent studies show that ultrasound stimulation can be considered as a therapeutic tool for the enhancement of bone fracture healing. Therefore, ultrasound has a twofold perspective for bone fracture healing: therapy and diagnosis/follow-up. This book is intended to give an overview of the field and consists of chapters detailing theoretical and experimental aspects of the interaction phenomena between ultrasound waves and bone. It was prepared for medical doctors, physical therapists and other health professionals, biomedical engineers and ultrasound researchers, and it shows recent findings on the application of ultrasound in clinical diagnosis (ultrasound imaging and quantitative ultrasound) and therapy for fractures. The basics of bone histology, mechanics and regeneration are presented, as well as an introduction to ultrasound physics, giving more insight for the comprehension of the several mechanisms involved.

This book highlights the potential of low-intensity pulsed ultrasound, or LIPUS, to introduce a new era in dentistry by revolutionizing the approach to dental treatment and providing a cure for pathologic conditions long considered untreatable. Readers will find information on all aspects of LIPUS, from its mode of action and biologic mechanisms to the full range of emerging clinical applications. The role of LIPUS in promoting dental tissue repair and regeneration and in tissue engineering is fully explained in a series of chapters focusing on stimulation of cell metabolism in the dentocraniofacial region, bone healing, periodontal regeneration, the temporomandibular joint, pulp cell differentiation, the salivary glands, and orthodontics. The past two decades have witnessed numerous discoveries that have enhanced the scope for use of therapeutic ultrasound in dentistry. In summarizing the latest knowledge in this exciting field, the book will be of interest to dental surgeons, orthodontists, periodontists, and other practitioners.

Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.