Surface Engineering And Functional Nanomaterials For Point Of Care Analytical Devices

This book chronicles the role of advanced nanomaterials and surface engineering technologies in the development of point-of-care biosensors for health and environmental monitoring. All aspects of nanomaterial synthesis and characterization, functionalization methods, sensing surface engineering, signal amplification strategies, use of innovative technologies to enhance sensor efficiency and performances, and innovative applications of nanobiosensors to tackle real-life problems are discussed in this book with a focus on optical and electrochemical based sensing. It also covers the detection of infectious diseases and various disease biomarkers, smartphone-based biosensing, and portable diagnostics module developments with a discussion on the working mechanisms of these devices in various domains. The book also illustrates the recent trends in biosensing, and an overview of the challenges and probable solutions for the translation of biosensors from laboratory prototypes to commercial success. ​

This book highlights the recent advancement in point-of-care testing (POCT) technologies utilizing ‘smart’ nanomaterials for the analysis of biomarkers related to disease, which includes metabolites, enzymes, proteins, nucleic acids, cancer cells and multidrug-resistant pathogen. The POCT refers to medical diagnostic tests performed near the place and time of patient care. During the recent pandemic of COVID-19, many realized the importance of affordable, rapid and accurate POCT devices and their usefulness to combat the spread of the infection. The chapters in this book describe the emergence of ‘smart’ nanomaterials with unique physical and chemical properties being utilized in POCT devices for immobilizing biorecognition elements and labels for signal generation, transduction and amplification. It showcases the applications of these smart nanomaterials and their superiority in developing point-of-care diagnostics devices in a wide range of applied fields like food industry, agriculture sector, water quality assessment, pharmaceuticals and tissue engineering. It also looks into the challenges associated and future direction of research in this promising field. This book caters as reference book for researches from the field of nanobiotechnology and biomedical sciences who are interested in the development of rapid, affordable and accurate POCT devices.

Smart Nanodevices for Point-of-Care Applications examines the latest trends on the capabilities of nanomaterials for point-of-care (PoC) diagnostics and explains how these materials can help to strengthen, miniaturize, and improve the quality of diagnostic devices. A thorough explanation of all-in-one nanosmart devices is included, incorporating all of the applications and fundamentals of these smart devices. This book provides practical information on the following: novel and effective smart materials, better-quality health management, effective management of a disease, potential point-of-care devices, and mobile nanosensors. Additional Features Includes in-depth research based collation of the latest trends of smart devices Provides practical information on all-in-one nanosmart devices Explains how nanomaterials can help to strengthen and improve the quality of diagnostic devices Emphasizes the development of smart nanodevices, especially the miniaturization aspect

This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare. ​

Analytical Applications of Graphene for Comprehensive Analytical Chemistry, Volume 91 in the Comprehensive Analytical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of interesting topics, including Graphene based Nanocomposites: Synthesis, Properties and Application as Electrochemical Sensors, Graphene based Sample Preparation Techniques, Graphene Based Sample Preparation Techniques, Graphene-based thin film nanocomposite membranes for separation and purification, Analytical Applications of Graphene Oxide for Membrane Processes as Separation and Concentration Methods, Physico-chemically Functionalized Hybrid Graphene Derivatives for Miniaturized Microfluidics and Biotransducer Platform, and much more. Other chapters cover Graphene-based chemiresistive gas sensors, Graphene based Sensors, Applications of graphene-based sensors for biomedical industries, Point of care applications with graphene in human life, Ethical, Legal, Social & Economics Issues of Graphene, Safety and toxicity concerns of graphene and its composites, and the Future of Analytical Chemistry with Graphene. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Comprehensive Analytical Chemistry series Contains the latest information on the analytical applications of graphene for analytical chemistry

This book comprehensively documents the application of Nanobiomaterials in the field of bio-medicine and diagnostics technologies by involving classical concepts/examples. Nanobiotechnology is an emerging area which encompasses all the facets of research of nano and biomaterials with their interaction with biological systems. The book briefly summarizes the various types of Nanomaterial’s, and highlights the recent developments in the synthesis of the nanomaterials for the diagnostic and therapeutic biomedical applications. It skilfully reviews the utilization of the nanomaterials alone or in combination with other bio-molecules as a contrast enhancer in in-vivo imaging, Nano-Theranostics, drug delivery, and sensing transducer matrix. It also discusses the current research on designing of the new Nanobiomaterials and their implementation in numerous fields including bio-medicine and diagnostics. Finally, it summarizes the future prospects and the commercial viability of Nanobiomaterials in the human health care.​

Miniaturized Analytical Devices An in-depth overview of integrating functionalized nanomaterials with mass spectrometry, spectroscopy, electrophoresis, and other important analytical techniques Miniaturized Analytical Devices: Materials and Technology is an up-to-date resource exploring the analytical applications of miniaturized technology in areas such as clinical microbiology, pharmaceuticals, agriculture, and environmental analysis. The book covers the integration of functional nanomaterials in mass spectrometry, microscopy, electrophoresis, and more—providing the state-of-the-art information required for successfully implementing a range of chemical analysis techniques on microchips. Featuring contributions from a panel of international experts in the field, the book begins with an introduction to selected miniaturized devices, nanomaterials, and analytical methods. Subsequent sections describe functionalized nanomaterials (FNMs) for miniaturized devices and discuss techniques such as miniaturized mass spectrometry for bioassays and miniaturized microscopy for cell imaging. The book concludes by exploring a variety of applications of miniaturized devices in areas including metal analysis, bioimaging, DNA separation and analysis, molecular biology, and more. This timely volume: Surveys the current state of the field and provides a starting point for developing faster, more reliable, and more selective analytical devices Focuses on the practical applications of miniaturized analytical devices in materials science, clinical microbiology, the pharmaceutical industry, and environmental analysis Covers a wide range of materials and analytical techniques such as microvolume UV-VIS spectroscopy, microchip and capillary electrophoresis, and matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) analysis Discusses the role of miniaturized analytical devices in securing a green and sustainable future Miniaturized Analytical Devices: Materials and Technology is essential reading for analytical chemists, analytical laboratories, materials scientists, biologists, life scientists, and advanced students in related fields.