Systems Analysis Of Chromatin Related Protein Complexes In Cancer
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Systems Analysis of Chromatin Related Protein Complexes in Cancer
Author | : Andrew Emili,Jack Greenblatt,Shoshana Wodak |
Publsiher | : Springer Science & Business Media |
Total Pages | : 320 |
Release | : 2013-08-13 |
Genre | : Medical |
ISBN | : 9781461479314 |
Download Systems Analysis of Chromatin Related Protein Complexes in Cancer Book in PDF, Epub and Kindle
Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.
Introduction to Epigenetics
Author | : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz |
Publsiher | : Springer Nature |
Total Pages | : 215 |
Release | : 2021-03-23 |
Genre | : Science |
ISBN | : 9783030686703 |
Download Introduction to Epigenetics Book in PDF, Epub and Kindle
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Systems Biology of Cancer
Author | : Sam Thiagalingam |
Publsiher | : Cambridge University Press |
Total Pages | : 597 |
Release | : 2015-04-09 |
Genre | : Mathematics |
ISBN | : 9780521493390 |
Download Systems Biology of Cancer Book in PDF, Epub and Kindle
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Endocytosis in Plants
Author | : Jozef Šamaj |
Publsiher | : Springer Science & Business Media |
Total Pages | : 337 |
Release | : 2012-10-02 |
Genre | : Science |
ISBN | : 9783642324628 |
Download Endocytosis in Plants Book in PDF, Epub and Kindle
Endocytosis is a fundamental cellular process by means of which cells internalize extracellular and plasma membrane cargos for recycling or degradation. It is important for the establishment and maintenance of cell polarity, subcellular signaling and uptake of nutrients into specialized cells, but also for plant cell interactions with pathogenic and symbiotic microbes. Endocytosis starts by vesicle formation at the plasma membrane and progresses through early and late endosomal compartments. In these endosomes cargo is sorted and it is either recycled back to the plasma membrane, or degraded in the lytic vacuole. This book presents an overview of our current knowledge of endocytosis in plants with a main focus on the key molecules undergoing and regulating endocytosis. It also provides up to date methodological approaches as well as principles of protein, structural lipid, sugar and microbe internalization in plant cells. The individual chapters describe clathrin-mediated and fluid-phase endocytosis, as well as flotillin-mediated endocytosis and internalization of microbes. The book was written for a broad spectrum of readers including students, teachers and researchers.
Ubiquitin Proteasome System
Author | : Matthew Summers |
Publsiher | : BoD – Books on Demand |
Total Pages | : 228 |
Release | : 2019-06-19 |
Genre | : Science |
ISBN | : 9781838804909 |
Download Ubiquitin Proteasome System Book in PDF, Epub and Kindle
The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.
The Drosophila Model in Cancer
Author | : Wu-Min Deng |
Publsiher | : Springer Nature |
Total Pages | : 251 |
Release | : 2019-09-13 |
Genre | : Medical |
ISBN | : 9783030236298 |
Download The Drosophila Model in Cancer Book in PDF, Epub and Kindle
This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
Epigenetic Mechanisms of Gene Regulation
Author | : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs |
Publsiher | : Unknown |
Total Pages | : 716 |
Release | : 1996 |
Genre | : Medical |
ISBN | : UOM:39015047449171 |
Download Epigenetic Mechanisms of Gene Regulation Book in PDF, Epub and Kindle
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Fundamentals of Chromatin
Author | : Jerry L. Workman,Susan M. Abmayr |
Publsiher | : Springer Science & Business Media |
Total Pages | : 594 |
Release | : 2013-12-04 |
Genre | : Medical |
ISBN | : 9781461486244 |
Download Fundamentals of Chromatin Book in PDF, Epub and Kindle
While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.