Targeted Cancer Treatment in Silico

Targeted Cancer Treatment in Silico
Author: Natalia L. Komarova,Dominik Wodarz
Publsiher: Springer Science & Business Media
Total Pages: 227
Release: 2013-11-19
Genre: Mathematics
ISBN: 9781461483014

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Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
Author: Kenneth K.W. To,William C.S. Cho
Publsiher: Academic Press
Total Pages: 460
Release: 2020-07-29
Genre: Science
ISBN: 9780128199039

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Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Targeted Cancer Therapy in Biomedical Engineering

Targeted Cancer Therapy in Biomedical Engineering
Author: Rishabha Malviya,Sonali Sundram
Publsiher: Springer Nature
Total Pages: 949
Release: 2023-04-11
Genre: Science
ISBN: 9789811997860

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This book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs. Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes. This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.

In Silico Chemistry and Biology

In Silico Chemistry and Biology
Author: Girish Kumar Gupta,Mohammad Hassan Baig
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 210
Release: 2022-05-09
Genre: Science
ISBN: 9783110493955

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In Silico Chemistry and Biology: Current and Future Prospects provides a compact overview on recent advances in this highly dynamic branch of chemistry. Various methods of protein modelling and computer-assisted drug design are presented, including fragment- and ligand-based approaches. Many successful practical applications of these techniques are demonstrated. The authors also look to the future and describe the main challenges of the field.

Combinatorial Approaches for Cancer Treatment from Basic to Translational Research

Combinatorial Approaches for Cancer Treatment  from Basic to Translational Research
Author: Daniela Spano,Aniello Cerrato,George Mattheolabakis
Publsiher: Frontiers Media SA
Total Pages: 206
Release: 2022-03-03
Genre: Science
ISBN: 9782889745708

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Metronomic Chemotherapy

Metronomic Chemotherapy
Author: Guido Bocci,Giulio Francia
Publsiher: Springer
Total Pages: 295
Release: 2014-09-04
Genre: Medical
ISBN: 9783662436042

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This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Targeting autophagy in cancer therapy Focus on small molecule modulators and new strategies

Targeting autophagy in cancer therapy  Focus on small molecule modulators and new strategies
Author: Chen Yi,Ryszard Pluta,Guan Wang,Liang Ouyang,Bo Liu
Publsiher: Frontiers Media SA
Total Pages: 158
Release: 2023-04-17
Genre: Science
ISBN: 9782832515747

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Phytochemistry An in silico and in vitro Update

Phytochemistry  An in silico and in vitro Update
Author: Shashank Kumar,Chukwuebuka Egbuna
Publsiher: Springer
Total Pages: 575
Release: 2019-06-25
Genre: Science
ISBN: 9789811369209

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Phytochemistry is the branch of science that deals with the study of plant-derived chemicals or compounds, which are also known as phytochemicals or plant-derived secondary metabolites. Plants are known to produce phytochemicals that are essential for their growth and reproduction, as they protect them from insects, pathogens, and herbivores. Some of the major groups of plant-derived secondary metabolites are phenolics, flavonoids, terpenoids, alkaloids, tannin etc. Plant-derived phytochemicals are pharmacologically active and have the potential to cure various human diseases and disorders. Natural plant products have been known for their medicinal properties for untold years, and form the basis of several medicinal systems such as Chinese, Unani, and Ayurvedic Medicine. This book offers an essential introduction to phytochemicals and their synthetic analogues. It discusses various in silico approaches used to identify pharmacologically active phytochemicals and their biological activities, as well as in vitro and in vivo models/assays that have been utilized for the pharmacological profiling of plant-derived products to combat cancer, diabetes, cardiovascular diseases and neurological disorders. The intended audience includes upper-level undergraduate and graduate students; researchers and scientists from the pharmaceutical/food chemistry/nutrition sciences/biochemistry, and clinical biochemistry fields; and medical students. Sharing the latest findings, the book will familiarize these readers with the concepts, chemistry, and tremendous potential of phytochemistry.