The Bioarchaeology Of Metabolic Bone Disease

The Bioarchaeology of Metabolic Bone Disease provides a comprehensive and invaluable source of information on this important group of diseases. It is an essential guide for those engaged in either basic recording or in-depth research on human remains from archaeological sites. The range of potential tools for investigating metabolic diseases of bone are far greater than for many other conditions, and building on clinical investigations, this book will consider gross, surface features visible using microscopic examination, histological and radiological features of bone, that can be used to help investigate metabolic bone diseases. Clear photographs and line drawings illustrate gross, histological and radiological features associated with each of the conditions Covers a range of issues pertinent to the study of metabolic bone disease in archaeological skeletal material, including the problems that frequent co-existence of these conditions in individuals living in the past raises, the preservation of human bone and the impact this has on the ability to suggest a diagnosis of a condition Includes a range of conditions that can lead to osteopenia and osteoporosis, including previous investigations of these conditions in archaeological bone

The Bioarchaeology of Metabolic Bone Disease, Second Edition provides an updated, comprehensive and invaluable source of information combining both clinical and paleopathological manifestations and effects on these groups of diseases. The range of potential tools for investigating metabolic diseases of bone are far greater than for many other conditions, hence this edition will consider the gross, radiological, histological and surface features using microscopic examination (light microscopy and scanning electron microscopy), that can be used to investigate metabolic bone diseases. Diagnostic tables have been updated with the latest information, including new research on vitamin C and D deficiency, cardiovascular disease and diabetes. This second edition continues to explore the paleopathological research, covering the light of clinical and epidemiological work relevant to better understand the extent of the co-morbidity of these conditions. This is a must-have resource that demonstrates the important role that the analysis of metabolic bone disease has within bioarcheology for improving our understanding of health and life in past populations. Presents a clear introduction to bone biology relevant to each disease process Highlights key issues and ideas to provoke critical analysis across the spectrum of disciplines in physical anthropology, paleopathology, medical history and forensic anthropology Contains clear and user-friendly instructions for macroscopic, radiological and histological diagnoses Reviews current challenges in bioarcheology and provides direction for future research

The explosive growth in the field of molecular biology over the last two decades has started to make a great impact on clinical medicine. Genes have been cloned for diseases that were poorly understood only a decade ago. Additionally, investigators are increasingly aware that there are strong genetic components to complex disorders, such as osteoporosis, that are not classically thought of as genetic disorders. New insights into the pathogenesis of metabolic bone diseases have been obtained from investigations into the molecular biology of these diseases and new therapies will become available based on these new insights. In The Genefies of Osteoporosis and Metabolie Bane Disease, I have assembled an internationally renowned group of experts to write the various chapters. Each of the authors is an expert in his/her field who is currently performing research on the content of their chapter and have made important contributions to the understanding of the clinical fea tures and pathophysiology of metabolic bone disease and genetics. The first part of The Genefies of Osteoporosis and Metabolie Bane Disease addresses issues related to genetic contributions to the development of osteoporosis and the many factors that must be considered when searching for genesthat predispose to osteoporosis. The second sec tion addresses recent advances in the clinical and molecular biological aspects of inherited metabolic bone disorders. The last section reviews the latest techniques for finding genes that predispose to metabolic bone diseases.

Emphasizes a practical approach to the diagnosis and management of metabolic bone disorders. Covers biochemistry and physiology of bone cell function, calcitonin, pathophysiology of calcium absorptive disorders, bone biopsies, osteoporosis, diagnosis and management of bone tumors, metabolic bone disorders in children, and much more.

Anatomy and biology of bone matrix and cellular elements; Skeletal physiology; Mineral homeostasis; Clinical evaluation of bone and mineral disorders; Disorders of serum minerals; Metabolic bone diseases; Genetic, developmenal, and dysplastic skeletal disorders; Acquired disorders of cartilage and bone; Paget's disease; Extraskeletal (ectopic) calcification and ossification; Nephrolithiasis; Dentistry.

Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.