The Combine Study

The guideline focuses specifically on evidence-based pharmacological treatments for AUD in outpatient settings and includes additional information on assessment and treatment planning, which are an integral part of using pharmacotherapy to treat AUD.

Finally, there is a cure for alcoholism. This is the first step. Featuring new and updated information and studies, including an introduction by actress Claudia Christian, the second edition of The Cure for Alcoholism delivers exactly what millions of alcoholics and families of alcoholics have been hoping for: a painless, dignified, and medically proven cure for their addiction. Backed by 82 clinical trials and research that extends back to 1964, The Sinclair Method deploys an opiate-blocking medication in a very specific way—in combination with ongoing drinking—to extinguish the addictive "software" in the brain. The de-addiction process rolls back the addictive mechanism in the brain to its original pre-addicted state—before the first drink was consumed, making this program an actual cure for alcoholism. Drs. Roy Eskapa and David Sinclair of The Sinclair Method have put together a sound scientific book that proves that with this particular method, alcoholism can be cured in more than 78 percent of patients. What's more, the treatment avoids the dangerous withdrawal symptoms, allowing patients to detox gradually and safely while they are still drinking. This removes the need for expensive and unpleasant inpatient rehabilitation programs. Actual drinking levels and cravings automatically decrease until control over alcohol is restored. The bottom line is that patients can control their drinking or stop altogether with the simple yet powerful process outlined in The Cure for Alcoholism. Including a new introduction by actress Claudia Christian about The Sinclair Method's impact on her life, updated trial information, and a letter explaining the treatment that can be given to doctors by patients, The Cure for Alcoholism is a revolutionary book for anyone who wants to gain control over drinking.

What are the most promising strategies to treat alcohol and drug abuse? What are their medical implications? Despite the enormous resources spent on treating alcoholism and drug dependence, there is still no satisfactory evaluation of their effectiveness or of the cost of the different alternatives. Programs designed to treat substance abuse should be built on a foundation of evidence-based knowledge. Yet it is almost impossible to cope with the increasing amount of scientific literature. This book thus represents a guide through the myriads of articles. The most comprehensive scientific review of its kind, it presents the findings from more than 1,600 studies on the effectiveness of different treatments. The work also includes a summary of the methods available to intervene against harmful levels of alcohol, with most of the studies making use of the Diagnostic and Statistical Manual of Mental Disorders (DSM) system. The extensive results are arranged in detailed tables, which may be searched using the accompanying CD-ROM. Also enclosed are a quality checklist and an extensive glossary explaining more than 70 terms. An invaluable tool for medical researchers, clinicians and doctors as well as healthcare providers and insurers, allowing them to save major resources by identifying ineffective treatments and being aware of cost-effective alternatives. With a foreword by Henry R. Kranzler, University of Connecticut, USA.

The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...

Integrating Psychological and Pharmacological Treatments for Addictive Disorders distills the complex literature on addiction, offering a curated toolbox of integrated pharmacological and psychotherapeutic treatments in chapters authored by leading experts. Introductory chapters on the epidemiology, etiology, and fundamentals of addiction treatment provide a concise overview of the state of the field. Subsequent chapters then focus on the treatment of specific substance use disorders and on gambling disorder. Finally, a chapter on the treatment of addiction in primary care addresses the opportunities for clinical care in non-specialist outpatient settings. Physicians, psychologists, social workers, and other mental health professionals will come away from the book with an essential understanding of evidence-based practice in treating addiction and the scientific foundations of those approaches. .