The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease
Author: Cheryl S Rosenfeld
Publsiher: Academic Press
Total Pages: 560
Release: 2015-10-10
Genre: Science
ISBN: 9780128016725

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The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease
Author: Cheryl Rosenfeld
Publsiher: Unknown
Total Pages: 135
Release: 2015-11-09
Genre: Electronic Book
ISBN: 1974804100

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Developmental Origins of Health and Disease

Developmental Origins of Health and Disease
Author: Peter Gluckman,Mark Hanson
Publsiher: Cambridge University Press
Total Pages: 542
Release: 2006-04-20
Genre: Medical
ISBN: 0521847435

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This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Developmental Origins of Health and Disease

Developmental Origins of Health and Disease
Author: Lucilla Poston,Keith Godfrey,Sir Peter Gluckman,Mark Hanson
Publsiher: Cambridge University Press
Total Pages: 239
Release: 2022-12-31
Genre: Medical
ISBN: 9781009272247

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Fully revised new edition highlighting the scientific and clinical advances in the field of developmental origins of health and disease. Explores new understanding of mechanisms such as epigenetics and the role of environmental influences on the fetus. Interventions throughout the lifespan and implications for public health are also covered.

Developmental Origins of Health and Disease DOHaD

Developmental Origins of Health and Disease  DOHaD
Author: Takeo Kubota,Hideoki Fukuoka
Publsiher: Springer
Total Pages: 95
Release: 2018-06-28
Genre: Medical
ISBN: 9789811055263

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This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

Epigenetics

Epigenetics
Author: Joel D. Wallach,Ma Lan,Gerhard N. Schrauzer
Publsiher: SelectBooks, Inc.
Total Pages: 443
Release: 2014-05
Genre: Health & Fitness
ISBN: 9781590792551

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WHAT IS EPIGENETICS? Epigenetics is an emerging field of science that studies alterations in gene expression caused by factors other than changes in the DNA sequence. Epigenetics: The Death of the Genetic Theory of Disease Transmission is the result of decades of research and its findings that could be as critical to our understanding of human health as Pasteur’s research in bacteriology. Dr. Joel “Doc” Wallach has dedicated his life work to identifying connections between certain nutritional deficiencies and a range of maladies, formerly thought to be hereditary, including Cystic Fibrosis and Muscular Dystrophy. This nexus between nutrition and so-called genetic disease has been observed in both humans and primates, and it is the central theme of Epigenetics. To bring us Epigenetics, Wallach has teamed with noted scholars Dr. Ma Lan and Dr. Gerhard N. Schrauzer. Their collective expertise gives this book its far reaching perspective. Epigenetics is of vital importance to anyone who wants real knowledge about how the human body functions, and it provides a path for better health. Epigentics dispels the dogma and misinformation propagated by medical institutions and doctors resistant to change. Epigenetics is the beginning of a new era of well-being on this planet.

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics
Author: Michael D. Waters,Claude L. Hughes
Publsiher: John Wiley & Sons
Total Pages: 790
Release: 2018-01-04
Genre: Medical
ISBN: 9781119023609

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Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Genetic and Epigenetic Insights Into the Developmental Origins of Health and Disease

Genetic and Epigenetic Insights Into the Developmental Origins of Health and Disease
Author: Tesfaye B. Mersha,Fasil Tekola-Ayele,Daniel Enquobahrie
Publsiher: Frontiers Media SA
Total Pages: 83
Release: 2022-04-21
Genre: Science
ISBN: 9782889747474

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