The Epstein Barr Virus

The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.

From the Best Selling author Dr. Kasia Kines. Take your life back! For anyone suffering from Epstein-Barr Virus (EBV), chronic fatigue, autoimmune disorders, Infectious Mononucleosis, or other mystery illnesses, this is a must read!Do you feel lost and hopeless, living a life of illness with no answers? Do you feel unsupported by your medical team, left to suffer alone with no guidance? Are you searching for solutions to get your health and life back on track?Finally, a book that speaks to both the medical community and people inflicted by both mono and chronic conditions caused by EBV!The expanse of this pivotal book is far reaching - many people may not yet know they have been infected with EBV (commonly known as the "kissing disease"), but yet they struggle every day with chronic symptoms such as severe brain fog, debilitating fatigue, headaches, fever, chills, sore throat, body aches, and abdominal discomfort and can't seem to find a successful treatment solution.Eventually, some go on to develop autoimmune disorders, e.g. Lupus, Multiple Sclerosis, or Hashimoto's Thyroiditis and even cancer and are told that their immune system is simply confused and is now attacking itself, left with no solutions or hope for recovery.Alarmingly, chronic EBV infection is almost completely missed in medical practice, and as a result of never being tested, misinterpreting the test results, not being diagnosed, or being mis-diagnosed by their doctors, millions of people suffer debilitating conditions for many years with no answers.But this suffering can be avoided. And with this book, answers can be found.Author Dr. Kasia Kines is considered by her colleagues to be "one of the most brilliant, and importantly, clinically experienced functional nutritionists in the world." In Epstein-Barr Virus Solution, Dr. Kines provides a groundbreaking examination of EBV and not only how it causes chronic fatigue, autoimmune disorders, and even cancer but also how recovery is possible. This book was written in hopes that it will globally change the way EBV is understood, diagnosed, and treated.The deep journey into the existing research sheds light on the EBV virus for both the seasoned medical community and the layperson. Along with the validated research, Epstein-Barr Virus Solution presents practical, time-tested, and evidence-based clinical solutions for the testing and medical nutrition therapy for EBV, testing and lab interpretation, unique supplementation protocols, recovery strategies for stress, insomnia, fatigue, and toxicity, pantry and kitchen rehab for EBV, and delicious anti-EBV recipes. Through Dr. Kines' compassionate guidance, readers will feel confident to discuss their concerns with their doctor, to ask for testing, and to take their lives back from EBV. Epstein-Barr Virus Solution urges medical providers to hear their clients' concerns and provides the medical community with the research and insights needed to avoid misdiagnosis and common problems with testing for EBV.Epstein-Barr Virus Solution was made possible because of Dr. Kines' long-standing expertise as a functional clinical nutritionist who has dedicated her practice to working with clients inflicted by EBV. Dr. Kines tells readers in easy-to-understand language that recovery and hope for better health are possible through targeted nutrition and lifestyle changes. Readers are given a toolkit full of practical advice and guidance, including exclusive materials from Dr. Kines' life-changing 30-Day Detox Program that she has taught successfully for over 10 years.The research is out there, and Dr. Kasia Kines has found it, synthesized it, and utilized it to implement successful treatment protocols in her own clinic. Clients who had suffered years with chronic EBV infection symptoms are now recovering and living their lives.This book will provide those infected with EBV everything they need to finally take control of their health and take their life and happiness back.

Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.

Relates the story of the discovery of the Epstein-Barr virus in 1964 and how scientists are gradually coming to understand it, and considers why the virus causes apparently unrelated diseases in different populations.

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Joanna Wilson and Gerhard May have assembled a collection of the key molecular biology protocols used in the analysis of Epstein-Barr virus (EBV), along with a series of valuable immunology, cell biology, and transgenic mouse protocols. These readily reproducible techniques include methods for gene expression with mini-EBV plasmids, for expression analysis by FISH, for EBV detection and quantitation, and for cell proliferation and death assays. In addition, there are EBV-based vectors, an up-to-date map of EBV, a comprehensive table of available latent protein antisera, and assays from in vitro to cell to organ to organism levels. Timely and highly practical, Epstein-Barr Virus Protocols provides powerful tools for elucidating the life cycle of EBV and its host interactions, work that promises the emergence of major new treatments and cures for EBV associated diseases, including several forms of human cancer.

Epstein-Barr virus (EBV) is a human gamma herpes virus that is best known for being the causative agent of infectious mononucleosis in man. A fascinating feature of this virus is its ability to persist in the host, and it is estimated that more than 95% of adults are carriers of the virus. Importantly, EBV can transform latently infected primary cells from healthy individuals into cancerous ones, thereby causing important human cancers such as B-cell neoplasms (e.g. Burkitt's lymphoma and Post-transplant lymphomas), certain forms of T-cell lymphoma, and some epithelial tumors (e.g. gastric carcinomas). Understanding viral latency, what triggers viral reactivation and the mechanism of transformation of normal host cells into malignant cells are critical for the development of strategies for the prevention and control of this intriguing virus and related cancers. In this book, expert EBV virologists comprehensively review this important subject from a genetic, biochemical, immunological, and cell biological perspective. Topics include: latent infections, EBV leader protein, EBNA-1 in viral DNA replication and persistence, EBNA-2 in transcription activation of viral and cellular genes, the nuclear antigen family 3 in regulation of cellular processes, molecular profiles of EBV latently infected cells, latent membrane protein 1 oncoprotein, regulation of latency by LMP2A, role of noncoding RNAs in EBV-induced cell growth and transformation, and the regulation of EBV latency by viral lytic proteins. This book is essential reading for all EBV virologists, as well as clinical and basic scientists working on oncogenic viruses.