The Fate Of The Inflammatory Macrophage With Resolution Of Inflammation

Macrophages were initially identified as a key element in the innate host response to infection and injury due to their phagocytic clearance and elimination of pathogenic and non-pathogenic entities. However, as macrophage research advanced it became clear that not only are these cells amenable to the acquisition of multiple plastic phenotypes during inflammatory responses to different pathogens, they also play a paramount role in the termination of inflammation and acquired immune responses. In addition, macrophages profoundly affect host physiology when they migrate to distant sites and differentiate to specialized cells, like foam cells, osteoclasts, adipose tissue- and tumor -associated macrophages and other macrophage-derived cell types. These processes are affected by the inflammation-resolution axis and can result in health threats, such as atherosclerosis, bone loss, obesity, fibrosis and cancer. This Research Topic issue will cover a wide range of topics in macrophage biology: 1. Macrophages in immune responses to pathogens 2. Macrophages in the termination of acute and acquired immunity. 3. The role of macrophages and their descendents in inflammation-associated pathologies. 4. Macrophage polarization and differentiation. Particular focus will be given to the modulation of macrophage phenotype and function following their encounter with apoptotic cells and the signaling cascades that govern these changes.

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

With contributions by numerous experts

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field. neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application