The Granulomatous Disorders

This authoritative account of the granulomatous disorders provides a comprehensive overview of this complex group of diseases. Collectively, these disorders can present a bewildering array of symptoms, affecting all the body systems. This volume takes full account of recent advances in our knowledge of the molecular biology and immunology of these disorders, and casts fresh light on their diagnosis and treatment. This timely publication is organised to include chapters focused on causative agents and those addressing affected body systems. Highly illustrated throughout, including numerous colour plates, it encompasses and integrates the very latest science, pathology and practical clinical advice. Compiled by international authorities with chapters which combine the expertise of both a pathologist and clinician, it is sure to become an essential source of reference for a very wide readership including infectious disease specialists, immunologists, pathologists, radiologists, ophthalmologists and general physicians.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the ‘Essential features’ of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.

Granulomatous disorders represent a unique group of diseases both non-infectious and infectious that require the utmost clinical pathologic correlation combined with a keen sense of inquiry for underlying systemic disease. Some of these diseases are common and some are rare; however all dermatologists need to diagnose and manage these diseases whether common or rare. This issue of Dermatology Clinics "Granulomatous Disorders of the Adult Skin" supplies the readers with a comprehensive, up to date, and evidence based review of multiple granulomatous disorders (i.e. palisdaing, epitheliod, xanthomatous, casseating, supprative, vasculitic, lymphoproliferative, foreign body). Dermatologists need to be able to differentiate the entities, evaluate patients for specific underlying systemic diseases (diabetes to cancer) and treat with a wide range of immunosuppressant to anti-infectious agents. This issue will help the dermatologist learn the most current etiopathogenesis, clinical/systemic manifestations and therapeutic modalities for these diseases. Other specialists who would find the information useful: Rheumatologists, Infectious Disease specialists, Hematologists/Oncologists, Endocrinologists, Pulmonologists, Oral-maxillary surgeons, and Pharmacists.

This case study is about a 15-year-old high-school student with a specific failure of phagocytes to produce H2O2and superoxide. It outlines the details of a phenotype of X-linked chronic granulomatous disease caused by mutations in the gene encoding gp91phox.