The Mif Handbook

The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science. Contents:MIF Structure and Mechanism of Action:MIF, MIF Alleles, and the Regulation of the Host Response (Richard Bucala)MIF and the Chemokine Axis (Sandra Kraemer, Christian Weber and Jürgen Bernhagen)CD74, the Natural Receptor for MIF, Regulates Cell Survival in Health and Disease (Idit Shachar, Maya Gordin, Sivan Cohen, Inbal Binsky, Ayelet Marom and Shirly Becker-Herman)Towards the MIF Interactome (Jörg Klug and Andreas Meinhardt)Structural Studies of Small Molecule Inhibitors of MIF (Yoonsang Cho and Elias J Lolis)Regulation of MIF Expression:Epigenetic Control of MIF Expression (Thierry Roger, Jérôme Lugrin, Xavier C Ding and Thierry Calandra)Regulation of MIF Gene Expression in the Lung (Lili Li and John Baugh)Hypoxic Adaptation Facilitated by MIF (Robert A Mitchell)Infectious and Inflammatory Diseases:MIF in Infectious Diseases (Marcelo Torres Bozza and Claudia Neto Paiva)Role of Macrophage Migration Inhibitory Factor (MIF) in Parasitic Diseases (Rashmi Tuladhar, Ran Dong, Sanjay Varikuti, John R David and Abhay R Satoskar)MIF and Pulmonary Disease (Gordon Cooke, Michelle E Armstrong, Helen Conroy and Seamas C Donnelly)The Role of MIF in Neurogenic Inflammation (Pedro L Vera and Katherine L Meyer-Siegler)MIF and Lower Urinary Tract Disorders (Anthony DeAngelis, Phillip P Smith and George A Kuchel)Neoplasia:MIF in the Pathogenesis of Urological Cancer (Katherine L Meyer-Siegler and Pedro L Vera)MIF in Ovarian Cancer: Detection and Treatment (Guy Nadel, Ayesha B Alvero and Gil Mor)The Role of MIF on Tumorigenicity of Embryonic Stem Cells (Yi Ren)Atherogenesis and Cardiovascular Disease:MIF in Atherosclerosis (Heidi Noels, Jürgen Bernhagen and Christian Weber)MIF in Cardiovascular Disease (Edward J Miller, Dake Qi, Ji Li and Lawrence H Young)Neurophysiology and Neuropathology:A Detrimental Role of MIF in Ischemic Brain Damage (Kate L Lambertsen and Tomas Deierborg)Association of MIF with Autism Spectrum Disorders (Ivana Kawikova, James F Leckman, Astrid Morer and Elena L Grigorenko) Readership: Basic scientists working in inflammation and immunity as well as cytokine biology; clinically oriented scientists in infectious diseases, clinical immunology, and rheumatology; pharmacologists; drug development groups. Keywords:Immunology;Cytokine;Inflammation;Immunopathology;Macrophase Migration Inhibitory FactorKey Features:A comprehensive and up-to-date handbook of the biology, biochemistry, and pathophysiology of MIFContributors are all leaders in their respective fields

The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.

These volumes provide a reference source of different gas chromatographic, liquid chromatographic, or thin-layer chromatographic techniques for the qualitative determination of various therapeutic agents, including antibiotics, vitamins and hormones, drugs of abuse in body fluids, dosage forms, or food stuffs. Over 5000 publications were reviewed to prepare tables of chromatographic data for 800 compounds, arranged alphabetically by generic drug name or by drug groups. A detailed summary of the extraction procedure described in each publication included in the table of a particular drug is also provided. This easy-to-read handbook is useful for selecting an appropriate chromatographic procedure for the determination of a given compound according to the available facilities.

This book focuses on the development and use of interoperability standards related to healthcare information technology (HIT) and provides in-depth discussion of the associated essential aspects. The book explains the principles of conformance, examining how to improve the content of healthcare data exchange standards (including HL7 v2.x, V3/CDA, FHIR, CTS2, DICOM, EDIFACT, and ebXML), the rigor of conformance testing, and the interoperability capabilities of healthcare applications for the benefit of healthcare professionals who use HIT, developers of HIT applications, and healthcare consumers who aspire to be recipients of safe and effective health services facilitated through meaningful use of well-designed HIT. Readers will understand the common terms interoperability, conformance, compliance and compatibility, and be prepared to design and implement their own complex interoperable healthcare information system. Chapters address the practical aspects of the subject matter to enable application of previously theoretical concepts. The book provides real-world, concrete examples to explain how to apply the information, and includes many diagrams to illustrate relationships of entities and concepts described in the text. Designed for professionals and practitioners, this book is appropriate for implementers and developers of HIT, technical staff of information technology vendors participating in the development of standards and profiling initiatives, informatics professionals who design conformance testing tools, staff of information technology departments in healthcare institutions, and experts involved in standards development. Healthcare providers and leadership of provider organizations seeking a better understanding of conformance, interoperability, and IT certification processes will benefit from this book, as will students studying healthcare information technology.

Choice Recommended Title, August 2019 Read an exclusive interview with Professor Vera Kolb here. Astrobiology is the study of the origin, evolution, distribution, and future of life on Earth. This exciting and significant field of research also investigates the potential existence and search for extra-terrestrial life in the Solar System and beyond. This is the first handbook in this burgeoning and interdisciplinary field. Edited by Vera Kolb, a highly respected astrobiologist, this comprehensive resource captures the history and current state of the field. Rich in information and easy to use, it assumes basic knowledge and provides answers to questions from practitioners and specialists in the field, as well as providing key references for further study. Features: Fills an important gap in the market, providing a comprehensive overview of the field Edited by an authority in the subject, with chapters written by experts in the many diverse areas that comprise astrobiology Contains in-depth and broad coverage of an exciting field that will only grow in importance in the decades ahead

A THOROUGH AND CONTEMPORARY EXPLORATION OF ISSUES FUNDAMENTAL TO MULTICULTURAL COMPETENCY Handbook of Multicultural Counseling Competencies draws together an expert group of contributors who provide a wide range of viewpoints and personal experiences to explore the identification and development of specific competencies necessary to work effectively with an increasingly diverse population. Beginning with a Foreword by Derald Wing Sue, this unique handbook offers a broad, comprehensive view of multiculturalism that is inclusive and reflective. The coverage in this important book lies beyond the scope of traditionally defined multiculturalism, with discussion of historically overlooked groups that have experienced prejudice and bias because of their size, social class, age, language, disability, or sexual orientation. This book provides readers with: Practical cases and examples to enhance skill development, promote critical thinking, and increase awareness A cross-section of diversity characteristics and best practice guidelines Examination of detailed, developmentally relevant competency categories Resources and exercises designed for practitioners at various levels of experience and expertise A forum for debate, discussion, and growth Designed to help readers enhance general multicultural competency and their ability to provide services to the populations specifically described, this thought-provoking text will prove useful in facilitating ongoing dialogues about multicultural competence in all its variations.

About the Book Beat the Devils is a memoir of the life of John R. David, which includes his research, discovering one of the first cytokines MIF (Migration Inhibitory Factor), a proinflammatory cytokine critical in autoimmunity and sepsis. John also worked on parasites affecting humans with new diagnostics and treatments. Read Beat the Devils and learn about John and his wife of 62 years, Roberta, working together; Lisa, his daughter, COO of Planned Parenthood and now CEO of Public Health Solutions; Joshua, his son, who started the High Line in NYC; John’s director father, who married Deana Durbin; how John sent 200,000 condoms twice to prevent HIV/AIDS at the Carnival in Salvador, Brazil; and much more. About the Author John R. David practices the piano for three hours a day and records duets with his wonderful composer/cellist/piano teacher, Andrea Casarrubios. John’s son and daughter live five minutes away and his two granddaughters, Nathalie and Claudia, are 25 minutes away, which he loves. He is a member of the National Academy of Medicine, American Academy of Arts and Science, and American Association of Immunologists. John attended Hollywood High School and the University of Chicago for college and medical school.

Handbook of Immunological Investigations in Children presents an extensive examination of the immune system of children. It discusses the fundamental concepts in immunology. It addresses studies in the primary immunodeficiency diseases. Some of the topics covered in the book are the respiratory disorders; renal disorders; gastrointestinal disorders; endocrine disorders; neurological and psychiatric disease; identifications of diseases of the skin; muscle malfunction and connective tissue disorder; and the methods of infections and immunizations. The definition and description of factors influencing blood and blood-forming elements are fully covered. An in-depth account of the factors causing allergies and cardiovascular diseases are provided. The general characteristics of severe combined immunodeficiency are completely presented. A chapter is devoted to usage of immunoglobulin therapy. Another section focuses on the disorders of neutrophils, monocytes, and macrophages. The book can provide useful information to immunologists, pediatricians, doctors, students, and researchers.