The Molecular Biology Of Membranes

This text attempts to introduce the molecular biology of cell membranes to students and professionals of diverse backgrounds. Although several membrane biology books are available, they do not integrate recent knowledge gained using modern molecular tools with more traditional membrane topics. Molecular techniques, such as cDNA cloning and x-ray diffraction, have provided fresh insights into cell membrane structure and function. The great excitement today, which I attempt to convey in this book, is that molecular details are beginning to merge with physiological responses. In other words, we are beginning to understand precisely how membranes work. This textbook is appropriate for upper-level undergraduate or beginning graduate students. Readers should have previous or concurrent coursework in biochemistry; prior studies in elementary physiology would be helpful. I have found that the presentation of topics in this book is appropriate for students of biology, biochemistry, biophysics and physiology, chemistry, and medicine. This book will be useful in courses focusing on membranes and as a supplementary text in biochemistry courses. Professionals will also find this to be a useful resource book for their personal libraries.

This well-organized, 'user friendly', and profusely illustrated work fills the need for an up-to-date textbook on the structure and function of biological membranes. In addition to the traditional topics covered in membrane biology courses, it discusses recent findings provided by cDNA cloning and X-ray diffraction to furnish the advanced undergraduate and graduate student with the most current, practical classroom resource available.

The purpose of this book is to give students and teachers a contemporary guide to the development in the structure and function of cell membranes.

Introduction to Biological Membranes: Composition, Structure and Function, Second Edition is a greatly expanded revision of the first edition that integrates many aspects of complex biological membrane functions with their composition and structure. A single membrane is composed of hundreds of proteins and thousands of lipids, all in constant flux. Every aspect of membrane structural studies involves parameters that are very small and fast. Both size and time ranges are so vast that multiple instrumentations must be employed, often simultaneously. As a result, a variety of highly specialized and esoteric biochemical and biophysical methodologies are often utilized. This book addresses the salient features of membranes at the molecular level, offering cohesive, foundational information for advanced undergraduate students, graduate students, biochemists, and membranologists who seek a broad overview of membrane science. Significantly expanded coverage on function, composition, and structure Brings together complex aspects of membrane research in a universally understandable manner Features profiles of membrane pioneers detailing how contemporary studies originated Includes a timeline of important discoveries related to membrane science

On February 14, 1977, a symposium entitled "The Molecular Biology of Membranes" was held in New Orleans in honor of Professor David E. Green, whose many contributions in mitochondrial structure and metabolism have influenced and guided research in this important area of biochemistry for many years. The symposium was attended by many former and present-day colleagues, friends, and interested scientists. The contents of this volume represent papers that were delivered at the symposium and other contributions from individuals who have been associates of Professor Green. We wish to thank Plenum Press for their help in making the symposium and publication of this book possible. Sidney Fleischer Youssef Hatefi David MacLennan Alexander Tzagoloff vii Contents Impressions of David E. Green by His Colleagues . . . . . . . . . . . . . . 1 Enzyme Institute Days 13 F. M. Huennekens Perspective for the Mitochondrion 17 David E. Green Chapter 1 Organization of Protein and Lipid Components in Membranes 29 Garret Vanderkooz Chapter 2 Structure of the Mitochondrion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 Robert A. Haworth and Douglas R. Hunter Chapter 3 Permeability of Membrane as a Factor Determining the Rate of Mitochondrial Respiration: Role of Ultrastructure . . . . . . . . . . . . . . 75 Jerzy Popinigis Chapter 4 Chemistry of Intrinsic Membrane Protein Complexes: Studies on Complex III and Cytochrome c Oxidase . . . . . . . . . . . . . . . . . . . . . . . 103 Roderick A. Capaldi ix x Contents Chapter 5 Reversible Mitochondrial ATPase as a Model for the Resolution of a 121 Membrane Complex A. E.

An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science. Brings together different facets of membrane research in a universally understandable manner Emphasis on the historical development of the field Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport.