The Plasticity Of Sex

The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations. This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas. Winner of the 2021 PROSE Award in Biomedicine from the Association of American Publishers! Discusses the role of biology in gender identity from research in genetics, endocrinology and neuroscience Addresses important health disparities and how to address them when treating the transgender patient Reviews evidence-based information on the biological basis and impact of environmental and hormonal factors at different life stages Outlines schema for treating variations in the sexuality and sexual function of the individual patient

A groundbreaking twentieth-century history of transgender children With transgender rights front and center in American politics, media, and culture, the pervasive myth still exists that today’s transgender children are a brand new generation—pioneers in a field of new obstacles and hurdles. Histories of the Transgender Child shatters this myth, uncovering a previously unknown twentieth-century history when transgender children not only existed but preexisted the term transgender and its predecessors, playing a central role in the medicalization of trans people, and all sex and gender. Beginning with the early 1900s when children with “ambiguous” sex first sought medical attention, to the 1930s when transgender people began to seek out doctors involved in altering children’s sex, to the invention of the category gender, and finally the 1960s and ’70s when, as the field institutionalized, transgender children began to take hormones, change their names, and even access gender confirmation, Julian Gill-Peterson reconstructs the medicalization and racialization of children’s bodies. Throughout, they foreground the racial history of medicine that excludes black and trans of color children through the concept of gender’s plasticity, placing race at the center of their analysis and at the center of transgender studies. Until now, little has been known about early transgender history and life and its relevance to children. Using a wealth of archival research from hospitals and clinics, including incredible personal letters from children to doctors, as well as scientific and medical literature, this book reaches back to the first half of the twentieth century—a time when the category transgender was not available but surely existed, in the lives of children and parents.

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Sex determination, differentiation and gamete maturation are well organised molecular events in vertebrates. In vertebrates, sex determination and differentiation are two important events in the development of gonads (testis or ovary). Sex determination is the genetic (sex chromosomes) or environmental process by which the sex (male or female) of an individual is established. During embryonic development, primordial germ cells migrate from the site of origin to the gonadal primordia where they differentiate along with somatic cells and finally form the indifferent/bipotential gonads. Depending on the action of various factors the bipotential gonads give rise to either testis or ovaries. In most vertebrates, excluding fishes and some amphibians, the event of sex determination is controlled genetically and later the progression of gonadal development is controlled by hormones and other factors. Interestingly, these processes in fishes are controlled not only genetically but also through hormones or environmental factors. These characteristics make fish the champions of sex reversal and serve as excellent animal models to precisely understand sexual development. The next interesting aspect is meiotic maturation which is essentially mediated by gonadotropins and progesterone metabolites to trigger final gamete maturation in fishes which is different from mammals. The novel aspects pertaining to gamete maturation has been studied in great detail in fish which depicts precise regulatory events of gamete maturation.

“[Fine’s] sharp tongue is tempered with humor. . . . Read this book and see how complex and fascinating the whole issue is.”—The New York Times It’s the twenty-first century, and although we tried to rear unisex children—boys who play with dolls and girls who like trucks—we failed. Even though the glass ceiling is cracked, most women stay comfortably beneath it. And everywhere we hear about vitally important “hardwired” differences between male and female brains. The neuroscience that we read about in magazines, newspaper articles, books, and sometimes even scientific journals increasingly tells a tale of two brains, and the result is more often than not a validation of the status quo. Women, it seems, are just too intuitive for math; men too focused for housework. Drawing on the latest research in neuroscience and psychology, Cordelia Fine debunks the myth of hardwired differences between men’s and women’s brains, unraveling the evidence behind such claims as men’s brains aren’t wired for empathy and women’s brains aren’t made to fix cars. She then goes one step further, offering a very different explanation of the dissimilarities between men’s and women’s behavior. Instead of a “male brain” and a “female brain,” Fine gives us a glimpse of plastic, mutable minds that are continuously influenced by cultural assumptions about gender. Passionately argued and unfailingly astute, Delusions of Gender provides us with a much-needed corrective to the belief that men’s and women’s brains are intrinsically different—a belief that, as Fine shows with insight and humor, all too often works to the detriment of ourselves and our society.

The first comprehensive synthesis on development and evolution: it applies to all aspects of development, at all levels of organization and in all organisms, taking advantage of modern findings on behavior, genetics, endocrinology, molecular biology, evolutionary theory and phylogenetics to show the connections between developmental mechanisms and evolutionary change. This book solves key problems that have impeded a definitive synthesis in the past. It uses new concepts and specific examples to show how to relate environmentally sensitive development to the genetic theory of adaptive evolution and to explain major patterns of change. In this book development includes not only embryology and the ontogeny of morphology, sometimes portrayed inadequately as governed by "regulatory genes," but also behavioral development and physiological adaptation, where plasticity is mediated by genetically complex mechanisms like hormones and learning. The book shows how the universal qualities of phenotypes--modular organization and plasticity--facilitate both integration and change. Here you will learn why it is wrong to describe organisms as genetically programmed; why environmental induction is likely to be more important in evolution than random mutation; and why it is crucial to consider both selection and developmental mechanism in explanations of adaptive evolution. This book satisfies the need for a truly general book on development, plasticity and evolution that applies to living organisms in all of their life stages and environments. Using an immense compendium of examples on many kinds of organisms, from viruses and bacteria to higher plants and animals, it shows how the phenotype is reorganized during evolution to produce novelties, and how alternative phenotypes occupy a pivotal role as a phase of evolution that fosters diversification and speeds change. The arguments of this book call for a new view of the major themes of evolutionary biology, as shown in chapters on gradualism, homology, environmental induction, speciation, radiation, macroevolution, punctuation, and the maintenance of sex. No other treatment of development and evolution since Darwin's offers such a comprehensive and critical discussion of the relevant issues. Developmental Plasticity and Evolution is designed for biologists interested in the development and evolution of behavior, life-history patterns, ecology, physiology, morphology and speciation. It will also appeal to evolutionary paleontologists, anthropologists, psychologists, and teachers of general biology.

THE BRILLIANT AND HUGELY INFLUENTIAL BOOK BY THE WINNER OF THE 2017 ROYAL SOCIETY INSIGHT INVESTMENT SCIENCE BOOKS PRIZE 'Fun, droll yet deeply serious.' New Scientist 'A brilliant feminist critic of the neurosciences ... Read her, enjoy and learn.' Hilary Rose, THES 'A witty and meticulously researched exposé of the sloppy studies that pass for scientific evidence in so many of today's bestselling books on sex differences.' Carol Tavris, TLS Gender inequalities are increasingly defended by citing hard-wired differences between the male and female brain. That's why, we're told, there are so few women in science, so few men in the laundry room – different brains are just suited to different things. With sparkling wit and humour, Cordelia Fine attacks this 'neurosexism', revealing the mind's remarkable plasticity, the substantial influence of culture on identity, and the malleability of what we consider to be 'hardwired' difference. This modern classic shows the surprising extent to which boys and girls, men and women are made – not born.