The Search For An Aids Vaccine

"The book is a balanced and comprehensive treatment of an important social issue. It is accessible to the general reader and belongs in public as well as academic libraries." -- Religious Studies Review "Painstaking analysis of the knotty ethical problems involved in human-subjects research, and a well-thought-out proposal for a community approach to conducting field trials for an HIV vaccine.... Highly recommended for medical ethicists and anyone concerned about the AIDS epidemic and how HIV research is conducted."Â -- Kirkus Reviews "... a carefully reasoned account of how research for and trial of a preventive vaccine differ from the methods used to discover a therapy."Â -- Booklist "I highly recommend reading this book which I would attest to be a thrilling, ethically challenging, and informative descent into the allopathic solution." -- Ryan Hosken, Bastyr University Library Newsletter "As the scientific effort to produce an efficacious vaccine continues, [Grady's] work provides an ethical compass that will guide us well, regardless of where phase III HIV vaccine trials ultimately occur." -- Journal of the American Medical Association "Highly recommended... " -- AIDS Book Review Journal "A remarkable treatment of a most difficult and complex subject... Grady's book is of special merit because it is simple, readable, and understandable, while conveying in-depth perceptions that are critical to the reader. A useful and essential reference work for those who would engage in the initiative to bring about a resolution of a mighty human health problem." -- Maurice R. Hilleman, Ph.D., D.Sc., Director, Merck Institute for Therapeutic Research "Dr. Grady's important study captures the complexity of the search for an AIDS vaccine with startling clarity. Her insights into the full range of forces that shape our national response to AIDS vaccine development should read like signposts to vaccinologists, AIDS community activists, and most importantly, the Public Health Service. An impressive contribution." -- Derek Hodel, Gay Men's Health Crisis "This book is recommended to medical ethicists, those involved in non-HIV vaccine trials, and all persons involved in HIV vaccine trials, including investigators, sponsors, study subjects and communities at risk." -- Journal of Health Politics, Policy and Law The creation of a vaccine now seems the best hope for controlling AIDS. Yet developing and testing an HIV vaccine raises a host of difficult ethical issues. These concerns are the focus of this timely and important book. Essential reading for everyone interested in ethics and the conduct of HIV vaccine research.

In 1984 it was announced that an AIDS vaccine would be ready for testing in two years. More than 15 years later only one vaccine has made it to a field trial. This text explains the reasons for this slow progress.

How many human immune systems are there? How old are they? Why is there no AIDS vaccine? Is a new approach needed? Why is public opinion growing skeptical of the scientific community after three decades of public awareness about HIV/AIDS? Consider answers to these puzzling questions. Learn from the decades of experience of two senior scholars: Dr. Omar Bagasra (an eminent molecular biologist, immunologist, and retrovirologist) and Dr. Donald Gene Pace (a highly published writer who examines public health policy). Explore intriguing new possibilities about human immunity, and the development of an effective AIDS vaccine. Read Immunology and the Quest for an HIV Vaccine. Benefit from an informed synthesis backed by a wealth of peer-reviewed scientific references. Review basic concepts of immunology, and stretch your perspective by contemplating this creative synthesis that provides a provocative treatise on the origin, evolution, and etiology of several forms of immune systems. Consider compelling ideas that will have an important bearing on HIV vaccine development. Enjoy this informative volume designed for anyone interested in the development of a safe AIDS vaccine, for anyone curious about present knowledge about human immunity, and for anyone yearning for a solution to the global pandemic that is AIDS.

How many human immune systems are there? How old are they? Why is there no AIDS vaccine? Is a new approach needed? Why is public opinion growing skeptical of the scientific community after three decades of public awareness about HIV/AIDS? Consider answers to these puzzling questions. Learn from the decades of experience of two senior scholars: Dr. Omar Bagasra (an eminent molecular biologist, immunologist, and retrovirologist) and Dr. Donald Gene Pace (a highly published writer who examines public health policy). Explore intriguing new possibilities about human immunity, and the development of an effective AIDS vaccine. Read Immunology and the Quest for an HIV Vaccine. Benefit from an informed synthesis backed by a wealth of peer-reviewed scientific references. Review basic concepts of immunology, and stretch your perspective by contemplating this creative synthesis that provides a provocative treatise on the origin, evolution, and etiology of several forms of immune systems. Consider compelling ideas that will have an important bearing on HIV vaccine development. Enjoy this informative volume designed for anyone interested in the development of a safe AIDS vaccine, for anyone curious about present knowledge about human immunity, and for anyone yearning for a solution to the global pandemic that is AIDS.

This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

The HIV/AIDS pandemic is the most devastating global public health crisis since the great plagues of the middle ages, with more than 14,000 new HIV infections and 8000 deaths due to AIDS every day. This book reviews the scientific challenges that have impeded the search for an effective AIDS vaccine.

Since 1984, the world has been spending, on the average, over $700 million annually in a futile effort at developing safe and effective HIV vaccines. During this period, over 25 million people have perished from the HIV/AIDS scourge, 90 per cent of them in the poor developing countries of sub-Saharan Africa. The socio-economic wreck caused by the HIV/AIDS pandemic is mind-boggling. The years of wayward search for safe and effective HIV vaccines since 1984 should have shown the world that the recipe for HIV vaccines that they have been following religiously without success should be appraised. That has not been done up till today. Instead, the entire world has persisted with the unscientific, unreasonable, bizarre, and ridiculous dogmas and established knowledge. Globally, the world has deceitfully been made to believe that these vaccines, if ever they would be developed, are at least a decade away. The author expects this book to be of immense interest to all mankind especially international Institutions/Agencies like the UN, UNAIDS and WHO, Governments and their Health Ministries/Departments, the world's major or leading Pharmaceutical Companies, Universities/Research Institutes, leading media houses such as the CNN, the BBC, VOA, AFP and the CBS, virologists, HIV vaccine researchers and developers, medical practitioners and students, medical laboratory scientists and students, registered and student nurses, epidemiologists, ethicists, HIV-infected persons and all those that are involved or interested in HIV vaccine research and development.

HIV and AIDS: A Global Health Pandemic by the Editors of Scientific American On June 5, 1981, the scientific community received a wake-up call from the CDC regarding a terrible and mysterious new illness that caused immune system failure. A year passed before it had a name: AIDS. Reported infections skyrocketed while science raced to understand a virus that hid among our own cells and mutated quickly. Three decades later, remarkable progress has been made but much more remains to be understood and to be done. In this book, HIV and AIDS: A Global Health Pandemic, Scientific American chronicles the war against the disease from its discovery by Robert Gallo and Luc Montagnier to the most current research on gene editing and potential drug targets. These articles explore where the disease came from, how it works, how it spreads, the search for a vaccine, and cultural and sociological factors. In this book, you'll find not only a record of crisis and unprecedented response, but also an essential source to understand the scientific struggle against HIV/AIDS.