The Treatment Of Glomerulonephritis

Glomerulonephritis is one of the commonest causes of end-stage renal failure worldwide. Although there have been considerable advances in the management of renal failure by dialysis and transplantation, there has been relatively little progress in its prevention. This volume sets out to review current practice in the treatment of glomerulonephritis, which is aimed both at controlling the clinical manifestations, e.g. nephrotic syndrome, and at preventing the progression to renal failure. The term glomerulonephritis covers a wide range of conditions with different immunological, histological and clinical features. This volume therefore starts with reviews of the immunology and pathology of different types of glomerulonephritis. This is followed by detailed consideration of the treatment of the commoner primary and secondary forms of the disease. There are separate chapters on special circumstances, such as glomerulonephritis in pregnancy or following renal transplantation. In each chapter, attempts are made to review the evidence for the effectiveness of treatment, based on controlled trials, immunopathological principles and the authors' considerable experience. Although some aspects of the treatment of glomerulonephritis can be found in the standard texts on renal disease, this volume provides an up-to-date, thoroughly referenced, and practical guide to management. As such, it should be of value to nephrologists and general physicians, including those in training, and to postgraduate students of nephrology.

This comprehensive yet concise guide to the treatment of even the most complex patients with primary glomerular diseases is full of practical information collected and organized in an easy-to-read manner, containing not only an evidence-based review of the topic but also practical recommendations from experts in the field.

Primary glomerulonephritis is one of the most common kidney diseases, and a frequent cause of kidney failure. Treatment of this disease is a constant concern for the clinician, as there are no precise guidelines available. This book brings together for the first time information on all aspectsof primary glomerulonephritis. It reports in detail the characteristics of the drugs used in treatment, gives a critical review of the results obtained from the trials of different drugs, and provides practical recommendations for the clinician.

Primary glomerulonephritis is a common renal disease which may eventually lead to chronic renal failure. Treatment of glomerulonephritis is difficult. In particular the use of glucocorticoids and immunosuppressive drugs require expertise, knowledge of the drugs, and careful monitoring of the patient. Paradoxically, the treatment of glomerulonephritis has become even more complicated in the recent years, after the introduction of a number of newer immunosuppressive drugs. Extensively updated since publication of the first edition in 1997, this comprehensive yet concise guide to the treatment of even the most complex patients with primary glomerular diseases is full of practical information collected and organized in an easy-to-read manner. It encompasses the possible treatments of the different types of primary glomerulonephritis, including diseases intrinsic to the kidney of unknown or uncertain aetiology. Each of the main chapters is devoted to a single primary glomerulonephritis and follows a similar format to allow easy access of information. The book contains not only an evidence-based review of the topic, but also practical recommendations from internationally recognized experts in the field.

This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.

This guideline presents clear criteria for testing of chronic kidney disease, for suspecting progressive CKD and referring people for specialist assessment.

Chinese, Asian and global perspectives Chronic kidney disease is a global major health issue that ultimately leads to end-stage renal disease, a devastating condition requiring costly renal replacement therapy. Given this background, extensive understanding of the pathogenesis of the disease and exploring novel therapeutic targets will help to alleviate disease progression, improve prognosis and reduce its impact on the global economic burden. Currently, primary glomerulonephritis is the leading cause of chronic kidney disease and end-stage renal disease in China and many other countries. Recently, there has been much progress with regard to pathogenesis as well as treatment of primary glomerulonephritis. Clinical data from Chinese studies have significantly contributed to the making of international guidelines and histological classifications of the disease. This book focuses on the cutting-edge knowledge and provides up-to-date information on primary glomerulonephritis. Topics covered are IgA nephropathy, focal segmental glomerulosclerosis, membranous nephropathy, membranoproliferative glomerulonephritis, and crescentic glomerulonephritis.

Concise, readable, and well-illustrated, Handbook of Glomerulonephritis is a convenient, one-stop resource for physicians, residents and fellows, advanced practice professionals, and nurses who are involved with the care of patients with glomerular diseases. Drs. Patrick H. Nachman, Michelle Rheault, and Edgar V. Lerma, along with a team of internationally renowned glomerulonephritis experts, provide practical guidance on both adult and pediatric glomerular diseases, across the spectrum of clinical presentations and pathogenic mechanisms.