Theranostic Imaging In Cancer Precision Medicine

Over the past few decades, there have been many dramatic innovations in cancer diagnosis and treatment strategies. Medical imaging plays a pivotal role in the diagnosis and treatment of cancer. It provides a comprehensive assessment of the tumors and their environments. Multiple imaging modalities are used for theranostics including optical (fluorescence or bioluminescence), nuclear (PET or SPECT), ultrasound, photoacoustic, CT, and MR imaging techniques. Radiomics is an approach for high-throughput extraction of quantitative imaging features or textures from imaging to decode histopathology and create high-dimensional datasets for feature extraction. Therefore, Radiomics may provide quantitative and objective support for decisions surrounding cancer detection and treatment.

Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics – the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

This comprehensive volume covers radiopharmaceuticals developed for pathway-directed systems in imaging and theranostic applications. We now are at the cutting edge of providing personalized treatment with increased use in oncology of these new radiopharmaceuticals. Trends in high-resolution instrumentation development, quality assurance systems and regulatory compliance for radiopharmaceuticals, clinical evaluation of radiopharmaceuticals, and benefits and pitfalls of the current clinical FDG PET are discussed. Radiopharmaceuticals are used for diagnosis of diseases of the central nervous and cardiovascular systems and for staging, restaging, and treatment planning for cancers. Nuclear biomarkers allow precise measurement of molecular pathways on a whole-body image upon administration of functional radiolabeled agents, and nuclear imaging agents have potential use in patient selection, pharmacokinetic, dosage-finding, and proof-of-concept studies. Nuclear imaging agents and hybrid instrumentation also provide sensitive and specific answers for differential responsiveness in therapeutic outcome. This book serves as a reference for moving the discovery and development of radiopharmaceuticals from the workbench to clinical applications. It thus benefits not only clinicians but also translational research scientists—molecular biologists, chemists, imaging scientists, pharmaceutical developers, physicists, and support staff.

The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome. Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine. This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field. Contents:Combining Imaging and Drug Delivery for the Treatment of Severe Diseases (Simona Mura and Patrick Couvreur)Increased Sensitivity for Medical Imaging Using Non-Ionizing Nanomedicine as Contrast Agents (Cyrille Richard, Bich-Thuy Doan and Nathalie Mignet)MRI T2 Weighted Theranostic Nanodevices and Chemotherapy (Sophie Laurent, Luce Vander Elst, Dimitri Stanicki and Robert N Muller)MRI T1 Weighted Theranostic Nanodevices (Lucie Sancey, François Lux, Géraldine Le Duc, Sabin Carme and Olivier Tillement)Optical Imaging and Chemotherapy (Guillaume Bort, Simona Mura and Patrick Couvreur)Plasmonic Nanoparticles-Coated Microbubbles for Theranostic Applications (Mark A Borden, Jacob D Dove and Todd W Murray)Contribution of Nuclear Medicine to Cancer Nanotheranostics (Thomas Lars Andresen, Anncatrine L Petersen, Anders E Hansen and Jonas R Henriksen)Nanotheranostics in Gene Therapy (Madhura Deshpande, Shravan Kumar Sriraman and Vladimir Torchilin)Nanotheranostics in Cardiovascular Diseases (Maya Juenet, Mariana Varna, Cédric Chauvierre and Didier Letourneur)Stimuli-Responsive Nanotheranostics (Basit Yameen, Jun Wu, Critian Vilos, Andrew Whyte David Werstler, Lori Pollit and Omid C Farokhzad)Advancing the Practical Clinical Utility in Personalized Medicine: Capabilities and Lessons Learned for Pharmacology and Pharmaceutics (Ioannis S Vizirianakis, Christina Karavasili, Elsa P Amanatiadou and Dimitrios G Fatouros) Readership: Advanced undergraduates, graduates, as well as experimental researchers in academia or the industry with an interest in this emerging concept in the nanomedicine world. Key Features:This book presents an integrated and transdisciplinary description of an emerging concept in the world of nanomedicine: nanotheranosticsThis work is one of the few dedicated to nanotheranostics and its applicationsWritten by well-recognized experts in academia, this book would offer to the reader a clear overview of the progresses in the field of nanotheranostics and their fundamental contribution to the field of personalized medicineReading this book would open the way to further improvements and to the possible clinical translation of the nanotheranostics concept in the not-too-distant futureKeywords:Bioengineering;Nanomedicine & Nanobiology;Biomedical Engineering;Medical Imaging;Therapy