Translational Neuroscience Of Speech And Language Disorders

This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language. To this end, this edited volume brings together contributions from several leading experts in a markedly broad range of disciplines, comprising Neurology, Neurosurgery, Genetics, Engineering, Neuroimaging and Neurostimulation, Neuropsychology, and Speech and Language Therapy.

Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions and tutor-dependent influences, on the learning of vocal communication. Songbird research has elucidated cellular and molecular mechanisms underlying learning and production of vocal patterns, perception of vocal sounds, vocal motor control and vocal neuromotor plasticity. More recently, the entire genome of the songbird zebra finch has been sequenced. These discoveries, along with the identification of several genes implicated in familial human speech and language disorders, have made it possible to look for analogues of speech and language dysfunction in zebra finches, at least at the perceptual and sensori-motor levels. Two approaches in particular have led us closer to the development of animal models of human speech conditions, namely developmental stuttering and a familial verbal dyspraxia associated with a mutation in the gene for the transcription factor FoxP2. Work on other animals that show developmental sensori-motor learning of vocal sounds used for communication have also shown significant progress, leading to the possibility of development of models of speech and language dysfunction in them. Among mammals, the principal ones include dolphins and whales. In non-human primates, while vocal learning per se is not very prominent, investigations on their communicative abilities have thrown some light on the rudiments of language. These considerations make the publication of a book focused on animal models of speech and language disorders, detailing the overall investigative approach of neurobehavioral studies in animals capable of vocal communication and learned vocalizations, a much-needed and worthwhile project. It would serve as a unifying review of research in this new multidisciplinary frontier, spanning the molecular to the behavioral, for clinicians and researchers, as well as a teaching resource for advanced speech pathology and neuroscience students. This book will also be the first of its kind.

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Clinical Neuroscience for Communication Disorders: Neuroanatomy and Neurophysiology offers a comprehensive and easy-to-understand introduction to neuroscience for undergraduates and beginning graduate students in the field of communication disorders. Packed with features to aid student understanding, this textbook introduces the neurologic underpinnings of systems involved in communication (speech, language, cognition, and hearing) and swallowing, from the nervous system to the anatomy of the head and neck. A highly readable writing style makes abstract and complex material accessible to students and provides just the right amount of information to challenge yet not overwhelm students. What sets this book apart is the extensive infusion of clinical application. Each chapter begins by tying the content to the everyday clinical applications for speech-language pathologists, audiologists, and related professionals and includes clinical cases to illustrate neural functions. In addition to coverage of the main systems, this text contains chapters devoted to neuroplasticity, communication, and cognition to move beyond basic anatomy to the key principles of contemporary neuroscience and application of the concepts discussed. Additionally, explicit connections are drawn between cranial nerves, the oral mechanism examination, and clinicall swallowing assessment. The clinical cases cover a variety of both pediatric and adult scenarios designed to highlight the interconnectedness of neural systems and the complexity of neurologically-based communication disorders. The cases span the breadth of clinical practice—developmental and acquired disorders, pediatric and adult cases, and disorders of speech, language, cognition, and hearing—and are cross-referenced with each of the other chapters for improved understanding. Key Features: * More than 150 customized illustrations solidify connections between anatomy and physiology * Clinical cases throughout the text and expanded versions of the cases in a stand-alone chapter illustrate clinical relevance of neuroanatomy and neurophysiology * Bolded keywords highlight foundational concepts and terminology * Boxes throughout the text offer an opportunity for applying learning through applications, exercises, glossaries of key terms, and clinical cases * End-of-chapter summaries provide an overview of the key concepts within the chapter in plain language * A bulleted list of key concepts concludes each chapter to reinforce learning outcomes * References and further reading augment student learning

This revised, updated Second Edition continues to give students a strong foundation in neuroanatomy as it applies to speech-language pathology and audiology. New features include: additional and revised color illustrations and tables to reinforce technical details; an expanded clinical discussion section with more case studies; and a technical glossary in the appendix. This concise, yet comprehensive, user-friendly book is the only neuroscience text that meets the educational needs of students who study communication disorders. For more information, visit http://connection.LWW.com/go/bhatnager.

This distinctive handbook is a key reference for both clinicians and researchers working in the scientific investigation of aphasia. The focus is on how the study of acquired language disorders has contributed to our understanding of normal language and its neural substrates, and to the clinical management of language disorders. The handbook is unique in that it reviews studies from the major disciplines in which aphasia research is conducted - cognitive neuropsychology, linguistics, neurology, neuroimaging, and speech-language pathology - as they apply to each topic of language. For each language domain (such as reading), there is a chapter devoted to theory and models of the language task, a chapter devoted to the neural basis of the language task (focusing on recent neuroimaging studies) and a chapter devoted to clinical diagnosis and treatment of impairments in that domain.

This book provides comprehensive coverage of speech and language disorders arising from pathological processes involving the subcortical structures of the brain. It gives an understanding of these disorders in terms of their neuropathological basis, clinical symptomatology and prognosis. A full discussion of contemporary models and theories of subcortical participation in speech and language processing is given, including discussion of the possible roles of structures such as the basal ganglia, subthalamic nucleus, thalamus and cerebellum. The book covers speech and language disorders associated with a variety of subcortical conditions, ranging from major degenerative conditions such as Parkinsons’ Disease, Huntington’s chorea and dystonia, through to acquired non-degenerative subcortical lesions arising from, for example, cerebrovascular accidents and sterotactic surgically induced lesions. In addition, a full description of the relevant assessment and treatment procedures currently recommended for use for each of the subcortical communication disorders is given.