Treatments From Toxins

Eliminate avoidable toxins, mitigate the effects of those you can’t avoid, and enjoy a longer life with this essential health guide from a pioneer in integrative medicine, Dr. Joe Pizzorno—the author, teacher, practitioner, and founder of Bastyr University, the country’s first and largest fully accredited university of natural medicine. Dr. Joe Pizzorno is convinced that lifelong good health rests on two key determinants: your exposure to toxins and your ability to process them in your body. While lifestyle, diet, and genetics all play a major role in well-being, many symptoms of declining health and chronic disease are rooted in toxic overload—our exposure to a barrage of chemicals, heavy metals, radiation, electromagnetic frequencies, and pollution that are the byproducts of modern life. While the human body has an innate capacity to detoxify, it cannot cope with the elevated levels of toxins we are exposed to today. Most alarmingly, this toxic overload has helped transform once rare diseases into epidemics affecting people of all ages. In The Toxin Solution, Dr. Pizzorno provides the proven detox and tailored methods he has developed to heal toxic overload and restore health in just eight weeks. With this essential guide you will learn how to: Avoid toxins in food and the products you use; Mend your gut and prepare for detox; Support your body in releasing the chemicals; Repair some of the damage toxins have caused. Fortunately, our bodies have a tremendous capacity for healing and recovery. With The Toxin Solution you will discover how releasing and avoiding toxins can help you to feel better today—and every day for the rest of your life.

As little as two decades ago, deliberately injecting botulinum toxin into patients would have seemed foolhardy at best and criminal at worst. The increased clinical use of botulinum toxins has expanded the body of knowledge available on the structure and function of these proteins. This knowledge can be applied to topics as varied as therapies based on the endopeptidase activity of the toxins, vaccine development, protection against botulism, and vectors for neuronal drug delivery. Based on recent scientific and clinical information from top international authorities, Treatments from Toxins: The Therapeutic Potential of Clostridial Neurotoxins reviews the status of current research and development and identifies significant developments. Drawing on their vast experience in this field, the editors present the basic background of the bacteriology and genetics of the neurotoxigenic clostridia, a history of the discovery of the neurotoxins, and an overview of the tetanus and botulism diseases. The chapters detailing common medical applications of the toxins cover side effects and novel uses, including neuronal drug delivery strategies, and provide a fresh look at what can still be achieved. They also explore the toxins as potential threat agents and the advent of the therapeutic use of botulinum toxins. Highlighting the pitfalls, successes, and challenges that exist when engineering complex proteins, the book brings together the clinical and theoretical worlds. It presents a broad overview of the current status of botulinum research and its clinical applications.

The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity. Structured to bring together exploration into the epidemiology, molecular mechanism, pathogenesis, environmental factors and management in cardiovascular toxins” Included various topics on cardiovascular toxins such as plant, chemical, animal, nanomaterial and marine biology induced cardiac damage – which are new ideas discussed in detail Comprehensive chapters on the cardiovascular toxicity from drugs, radiotherapy and radiological imaging Enables you to manage multiple clinical cases of cardiovascular toxicity Outlined conclusions at the end of each chapter providing “key learning points” to help you organize the chapter’s details without losing insight

Open access edition: DOI 10.6069/9780295749013 At first glance, medicine and poison might seem to be opposites. But in China’s formative era of pharmacy (200–800 CE), poisons were strategically employed as healing agents to cure everything from abdominal pain to epidemic disease. Healing with Poisons explores the ways physicians, religious figures, court officials, and laypersons used toxic substances to both relieve acute illnesses and enhance life. It illustrates how the Chinese concept of du—a word carrying a core meaning of “potency”—led practitioners to devise a variety of methods to transform dangerous poisons into effective medicines. Recounting scandals and controversies involving poisons from the Era of Division to the Tang, historian Yan Liu considers how the concept of du was central to how the people of medieval China perceived both their bodies and the body politic. He also examines the wide range of toxic minerals, plants, and animal products used in classical Chinese pharmacy, including everything from the herb aconite to the popular recreational drug Five-Stone Powder. By recovering alternative modes of understanding wellness and the body’s interaction with foreign substances, this study cautions against arbitrary classifications and exemplifies the importance of paying attention to the technical, political, and cultural conditions in which substances become truly meaningful. Healing with Poisons is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem) and the generous support of the University of Buffalo.

Did you know that high levels of toxins in the human body can be linked to common conditions such as infertility, obesity, rheumatoid arthritis, heart disease, and diabetes? With therapeutic guidance designed for clinicians, Clinical Environmental Medicine focuses on how toxins such as arsenic, lead, mercury and organophosphates have become one of the leading causes of chronic disease in the industrial world. The first edition of this text describes how to treat these undesirable elements and molecules that can poison enzyme systems, damage DNA, increase inflammation and oxidative stress, and damage cell membranes. Expert authors Walter Crinnion and Joseph E. Pizzorno offer practical guidance for assessing both total body load as well as specific toxins. In addition, evidence-based treatment procedures provide recommendations for decreasing toxin exposure and supporting the body’s biotransformation and excretion processes. NEW! Unique! Practical diagnostic and therapeutic guidance designed for clinicians. NEW! Unique! Coverage of the most common diseases for which toxins are a primary cause. NEW! Description of how each toxin causes damage provides insights into sources, body load, and interventions for each toxin. NEW! Unique! Entirely evidence-based content focuses on the most common conditions from which patients suffer. NEW! Unique! Coverage of environmental toxicants, endogenous toxicants, and "toxins of choice" focuses on non-industrially-exposed populations.

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Removal of Toxic Pollutants through Microbiological and Tertiary Treatment: New Perspectives offers a current account of existing advanced oxidation strategies - including their limitations, challenges, and potential applications - in removing environmental pollutants through microbiological and tertiary treatment methods. The book introduces new trends and advances in environmental bioremediation technology, with thorough discussion of recent developments in the field. Updated information as well as future research directions in the field of bioremediation of industrial wastes is included. This book is an indispensable guide to students, researchers, scientists, and professionals working in fields such as microbiology, biotechnology, environmental sciences, eco-toxicology, and environmental remediation. The book also serves as a helpful guide for waste management professionals and those working on the biodegradation and bioremediation of industrial wastes and environmental pollutants for environmental sustainability. Introduces various treatment schemes, including microbiological and tertiary technologies for bioremediation of environmental pollutants and industrial wastes Includes pharmaceutical wastewater, oil refinery wastewater, distillery wastewater, tannery wastewater, textile wastewater, mine tailing wastes, plastic wastes, and more Describes the role of relatively new treatment technologies and their approaches in bioremediation, including molecular and protein engineering technologies, microbial enzymes, bio surfactants, plant-microbe interactions, and genetically engineered organisms Provides many advanced technologies in the field of bioremediation and phytoremediation, including electro-bioremediation technology, microbial fuel cell technology, nano-bioremediation technology, and phytotechnologies

The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.