Type 2 Diabetes And Dementia

Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications

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The American diet is typically high in sugar consumption and extremely acidic. This lifestyle leads to insulin resistance, inflammation, diabetes, high blood pressure, risk for heart attack or stroke, and possibly dementia and Alzheimer’s disease. In The New Threat of Type 3 Diabetes, authors Alan D. Raguso and Maria Lizotte offer an understanding of diabetes, discussing why people’s health declines and why they get sick. Based on their personal and professional experiences with diabetes, they discuss concepts of body chemistry, look at inflammation as a health risk, and share how it’s a result of improper food intake, heredity, and environmental conditions, along with economics, poor pH balance, lack of moderate exercise, and the modern technological world. Raguso and Lizotte tell how type 3 diabetes is a newly accepted category, connecting a lifetime of damage caused by excessive blood sugar levels. With illustrations and graphics included, The New Threat of Type 3 Diabetes reviews the basic definitions of medical terms, the possible connections to prediabetes, type 2 and type 3 diabetes, and the steps that can be taken to prevent or reverse these diseases. Raguso and Lizotte suggest ways to make simple changes to live more healthily, better, and longer.

In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. The WPA is providing an update of currently available evidence on these interrelationships by the publication of three books, dealing with the comorbidity of depression with diabetes, heart disease and cancer. Depression is a frequent and serious comorbid condition in diabetes, which adversely affects quality of life and the long-term prognosis. Co-occurrent depression presents peculiar clinical challenges, making both conditions harder to manage. Depression and Diabetes is the first book devoted to the interaction between these common disorders. World leaders in diabetes, depression and public health synthesize current evidence, including some previously unpublished data, in a concise, easy-to-read format. They provide an overview of the epidemiology, pathogenesis, medical costs, management, and public health and cultural implications of the comorbidity between depression and diabetes. The book describes how the negative consequences of depression in diabetes could be avoided, given that effective depression treatments for diabetic patients are available. Its practical approach makes the book ideal for all those involved in the management of these patients: psychiatrists, psychologists, diabetologists, general practitioners, diabetes specialist nurses and mental health nurses.

This book is designed to guide all physicians in long-term care, in-, and outpatient settings who work with elders with co-current dementia and medical comorbidities. Chapters cover a wide range of challenging topics, including epidemiological data, evaluation and management techniques to optimize physical and cognitive function in patients with dementia, safety measures, and nonpharmacologic measures to support cognition. Chapters also discuss the unique aspects of managing the most common chronic diseases and the management of musculoskeletal pain in elders with dementia. Except for the introductory chapter, each chapter will include a case vignette to highlight some of the primary challenges of management of the particular chronic disease/condition in elders with dementia, making this an accessible and highly practical tool for medical professionals of all backgrounds. Written by experts in the field, Dementia and Chronic Disease is an excellent resource for all medical professionals treating patients with dementia, including geriatricians, family medicine physicians, social workers, nurses, hospitalists, and all others.

The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.