Uncontrolled Spread

NEW YORK TIMES BESTSELLER “Uncontrolled Spread is everything you’d hope: a smart and insightful account of what happened and, currently, the best guide to what needs to be done to avoid a future pandemic." —Wall Street Journal “Informative and well paced.”—The Guardian “An intense ride through the pandemic with chilling details of what really happened. It is also sprinkled with notes of true wisdom that may help all of us better prepare for the future.”—Sanjay Gupta, MD, chief medical correspondent, CNN Physician and former FDA commissioner Scott Gottlieb asks: Has America’s COVID-19 catastrophe taught us anything? In Uncontrolled Spread, he shows how the coronavirus and its variants were able to trounce America’s pandemic preparations, and he outlines the steps that must be taken to protect against the next outbreak. As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced. A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security. Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks. Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.

* NATIONAL BESTSELLER * “Painfully good. The book could have been called, ‘Outrageous.’ The story Andy Slavitt tells is not just about Trump’s monumental failures but also about the deeper ones that started long before, with our health system, our politics, and more.” --Atul Gawande, author of Being Mortal The definitive, behind-the-scenes look at the U.S. Coronavirus crisis from one of the most recognizable and influential voices in healthcare From former Biden Senior Advisor Andy Slavitt, Preventable is the definitive inside account of the United States' failed response to the Coronavirus pandemic. Slavitt chronicles what he saw and how much could have been prevented -- an unflinching investigation of the cultural, political, and economic drivers that led to unnecessary loss of life. With unparalleled access to the key players throughout the government on both sides of the aisle, the principal public figures, as well as the people working on the frontline involved in fighting the virus, Slavitt brings you into the room as fateful decisions are made and focuses on the people at the center of the political system, health care system, patients, and caregivers. The story that emerges is one of a country in which -- despite the heroics of many -- bad leadership, political and cultural fractures, and an unwillingness to sustain sacrifice light a fuse that is difficult to extinguish. Written in the tradition of The Big Short, Preventable continues Andy Slavitt’s important work of addressing the uncomfortable realities that brought America to this place. And, he puts forth the solutions that will prevent us from being here again, ensuring a better, stronger country for everyone.

Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work. It discusses the interactions which control the structure of virus particles, the ways viruses infect cells, how viruses replicate themselves, and the consequences and pathogenesis of virus infection for host organisms. This fully updated edition also reflects advances made in the field and includes new content on phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses. With the addition of ancillary resources, Principles of Molecular Virology, Seventh Edition is an essential foundational reference for academics, graduate students, and advance undergraduates in virology, molecular biology, and microbiology as well as researchers entering virology, infectious disease, and immunology research. Provides a conceptual approach to the principles of molecular virology, with important examples of new advances in virology Includes new concepts in this edition include coverage of emerging topics and new technologies in viral research like phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses Contains updated learning outcomes and further reading for each chapter Supported by online resources for students and instructors

Jedes Jahr breiten sich invasive gebietsfremde Arten in neue Ökosysteme aus. Die von den Eindringlingen verursachten Auswirkungen können sich in kürzester Zeit bemerkbar machen und verheerend sein. Das Thema der invasiven gebietsfremden Arten ist umfassend, komplex und auf verschiedenen Ebenen von globaler Bedeutung. Verschärft wird es durch die Globalisierung der Weltwirtschaft und den zunehmenden Handel, durch den die natürlichen Barrieren für den Transfer von Arten durchbrochen werden. Invasive gebietsfremde Arten bedrohen die weltweite Nahrungsmittelversorgung, die Qualität und Verfügbarkeit von Trinkwasser sowie die Stromproduktion und -versorgung. Zusammen mit den zusätzlichen Risiken durch den globalen Klimawandel ist die weltweite Homogenisierung von Pflanzen, Tieren und Mikroben ein wesentlicher Faktor für den sich verschlechternden Gesundheitszustand der Ökosysteme und die nachlassenden Ökosystemdienstleistungen überall auf der Welt. Um dieser Entwicklung entgegenzuwirken, besteht die dringende Notwendigkeit einer einheitlichen Ausrichtung von Regierungen, Kulturen und Programmen und einer besseren grenzüberschreitenden Koordination. Nur so lassen sich die vielfältigen Bedrohungen durch invasive gebietsfremde Arten für die Umwelt, die Wirtschaft und die Gesundheit von Pflanzen und Tieren sowie insbesondere die menschliche Gesundheit effektiv bekämpfen. Dieses vierbändige Werk ist das erste, das einen umfassenden Satz nützlicher Materialien zu den zentralen Themen bereitstellt, um die gesamte globale Bedrohung durch invasive gebietsfremde Arten sowie die vielfältigen Probleme in verschiedenen Teilen der Welt deutlich zu machen, und es enthält Material, in dem potenziell replizierbare Lösungen zur Überwindung dieser Bedrohungen aufgezeigt werden. Das Werk betont die Bedrohung durch invasive gebietsfremde Arten auch im Sinne eines globalen ?Aufrufs zum Handeln?. Invasive Arten kennen keine Grenzen. Daher hoffen wir, dass wir durch die Zusammenstellung von Material, das unterschiedliche wissenschaftliche und gesellschaftliche Standpunkte aus aller Welt berücksichtigt, sowie durch die Vermittlung von Erkenntnissen und Beispielen zu einer Vielzahl damit zusammenhängender Themen das globale Bewusstsein stärken und einheitliche nationale Reaktionen auf die Bedrohung durch invasive gebietsfremde Arten fördern können.

This powerful report on what went wrong—and right—with America’s Covid response, from a team of 34 experts, shows how Americans faced the worst peacetime catastrophe of modern times Our national leaders have drifted into treating the pandemic as though it were an unavoidable natural catastrophe, repeating a depressing cycle of panic followed by neglect. So a remarkable group of practitioners and scholars from many backgrounds came together determined to discover and learn lessons from this latest world war. Lessons from the Covid War is plain-spoken and clear sighted. It cuts through the enormous jumble of information to make some sense of it all and answer: What just happened to us, and why? And crucially, how, next time, could we do better? Because there will be a next time. The Covid war showed Americans that their wondrous scientific knowledge had run far ahead of their organized ability to apply it in practice. Improvising to fight this war, many Americans displayed ingenuity and dedication. But they struggled with systems that made success difficult and failure easy. This book shows how Americans can come together, learn hard truths, build on what worked, and prepare for global emergencies to come. A joint effort from: Danielle Allen • John M. Barry • John Bridgeland • Michael Callahan • Nicholas A. Christakis • Doug Criscitello • Charity Dean • Victor Dzau • Gary Edson • Ezekiel Emanuel • Ruth Faden • Baruch Fischhoff • Margaret “Peggy” Hamburg • Melissa Harvey • Richard Hatchett • David Heymann • Kendall Hoyt • Andrew Kilianski • James Lawler • Alexander J. Lazar • James Le Duc • Marc Lipsitch • Anup Malani • Monique K. Mansoura • Mark McClellan • Carter Mecher • Michael Osterholm • David A. Relman • Robert Rodriguez • Carl Schramm • Emily Silverman • Kristin Urquiza • Rajeev Venkayya • Philip Zelikow

This book provides guidance on the design of timber buildings for fire safety, developed within the global network Fire Safe Use of Wood (FSUW) and with reference to Eurocode 5 and other international codes. It introduces the behaviour of fires in timber buildings and describes strategies for providing safety if unwanted fires occur. It provides guidance on building design to prevent any fires from spreading while maintaining the load-bearing capacity of structural timber elements, connections and compartmentation. Also included is information on the reaction-to-fire of wood products according to different classification systems, as well as active measures of fire protection, and quality of workmanship and inspection as means of fulfilling fire safety objectives. Presents global guidance on fire safety in timber buildings Provides a wide perspective, covering the whole field of fire safety design Uses the latest scientific knowledge, based on recent analytical and experimental research results Gives practical examples illustrating the importance of good detailing in building design Fire Safe Use of Wood in Buildings is ideal for all involved in the fire safety of buildings, including architects, engineers, firefighters, educators, regulatory authorities, insurance companies and professionals in the building industry.