Unleashing Innovation On Precision Public Health Highlights From The Mcbios Maqc 2021 Joint Conference

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Cloud computing offers many advantages to researchers and engineers who need access to high performance computing facilities for solving particular compute-intensive and/or large-scale problems, but whose overall high performance computing (HPC) needs do not justify the acquisition and operation of dedicated HPC facilities. There are, however, a number of fundamental problems which must be addressed, such as the limitations imposed by accessibility, security and communication speed, before these advantages can be exploited to the full. This book presents 14 contributions selected from the International Research Workshop on Advanced High Performance Computing Systems, held in Cetraro, Italy, in June 2012. The papers are arranged in three chapters. Chapter 1 includes five papers on cloud infrastructures, while Chapter 2 discusses cloud applications. The third chapter in the book deals with big data, which is nothing new – large scientific organizations have been collecting large amounts of data for decades – but what is new is that the focus has now broadened to include sectors such as business analytics, financial analyses, Internet service providers, oil and gas, medicine, automotive and a host of others. This book will be of interest to all those whose work involves them with aspects of cloud computing and big data applications.