Unravelling Cancer Signaling Pathways A Multidisciplinary Approach

Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Protein Interactions A fundamental guide to the burgeoning field of protein interactions From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology. Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior. Protein Interactions readers will also find: Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces A data-driven approach incorporating machine learning and integrating experimental data into computational models An outlook on the current challenges in the field and suggestions for future research Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.

A multidisciplinary understanding of the various processes leading to colorectal cancer progression is important for creating promising methods of therapy. Therefore it is necessary to scrutinize the progression of cancer and the therapeutic process through various academic theories. This book examines colorectal cancer - its prevention, pathogenesis, and treatment - through a multidisciplinary lens in an effort to advance understanding of the disease and improve therapeutic efficacy.

Discover 'Optimizing Well-Being in Hypopharyngeal Cancer,' a comprehensive guide tailored to patients and caregivers navigating the challenges of this condition. Written by medical experts, this treatise offers a holistic approach to managing hypopharyngeal cancer, providing invaluable insights into its medical intricacies, anatomy, risk factors, and pathogenesis. Readers will delve into the world of hypopharyngeal cancer, gaining a profound understanding of its genetic and epigenetic alterations, the role of oncogenes and tumor suppressors, and the intricate cell signaling pathways involved. Explore the latest research on biomarkers, metabolism, and immunological aspects, empowering you with knowledge to make informed decisions about your treatment journey. With chapters dedicated to surgical techniques, radiation therapy, chemotherapy, targeted therapies, immunotherapy, and palliative care, this treatise equips you with a comprehensive toolkit to combat hypopharyngeal cancer effectively. Dive into the world of cutting-edge treatments and emerging therapies, guided by the expertise of medical professionals. Additionally, this guide delves into complementary and alternative therapies, offering insights into their safe integration alongside conventional treatments. Explore the benefits of mind-body practices, social support, and coping strategies that enhance your emotional and psychological well-being. As you navigate your cancer journey, this treatise provides crucial guidance on survivorship, quality of life assessment, and holistic approaches to well-being. Empower yourself with knowledge, resilience, and the support needed to optimize your well-being in the face of hypopharyngeal cancer. 'Optimizing Well-Being in Hypopharyngeal Cancer' is your indispensable companion on the path to recovery and a resource you can trust. Start your journey to well-being today, and let this guide be your beacon of hope and healing.

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment