Upper Tract Urothelial Carcinoma

Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. It's aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage and patient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy is covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.

Upper Urinary Tract Urothelial Carcinoma was at one time felt to be a somewhat rare entity. With the success of various treatments for bladder urothelial carcinoma, the incidence of this disease in the uretere and kidney is rising. Many medical subspecialists encounter these complex patients and a multimodality treatment plan is often required for care.

This book provides a practical, comprehensive, state-of-the-art review of bladder cancer. A valuable resource for anyone with an interest in urothelial tumors, this text brings together a multidisciplinary team of experts who have distilled their vast years of experience and knowledge into a concise, easy to digest format. Topics covered range from importance of a pattern recognition in diagnosis and pathologic evaluation to ‘how I do it’ tips on patient selection for appropriate therapies such as chemotherapy, immunotherapy, surgery and radiation. Bridging the gap between a traditional textbook and hands-on experience, this book provides a practical guide to managing day-to-day issues and challenges and brings an algorithmic approach to avoid common pitfalls. Bladder Cancer: A Practical Guide provides a concise yet comprehensive summary of the current status of the field of bladder cancer treatment, guiding patient management and stimulating investigative efforts.

The first edition of The Paris System for Reporting Urinary Cytology introduced a completely new paradigm for detecting bladder cancer by urine cytology. This system concentrated on defining morphological characteristics of the most clinically significant form of bladder cancer, High Grade Urothelial Carcinoma. This new approach has been widely accepted throughout the world, and has become part of the daily practice of cytology. Considering that the first edition of The Paris System (TPS) introduced a new model of urinary cytodiagnosis, verification and expansion of initial material and data were anticipated. Based on evolving knowledge and readership requests, the group of highly experienced authors have created a new edition of TPS. This second edition includes areas and issues not originally covered. A new chapter on urine cytology of the upper tract, a rarely addressed topic, has been introduced. Furthermore, the issue of cellular degeneration is discussed in the criteria of all diagnostic categories. Examples of standardized reports are included in each chapter. Most importantly, a separate chapter presents data defining the risk of malignancy (ROM) for each diagnostic category to inform clinical management. New high quality images augment those of the first edition to better illustrate diagnostic clues and potential pitfalls. In addition to chapters on diagnostic criteria, current concepts of pathogenesis of bladder cancer, specimen adequacy and preparation, and ancillary tests are covered in separate chapters. A bonus to the volume is a comprehensive history of urine as the earliest diagnostic sample of human disease, richly illustrated with artworks from major museums. Written by internationally recognized authorities, this comprehensive and evidence-based guide to urine cytology is supported by the newest data confirming the original concept and significance of diagnostic criteria defining High Grade Urothelial Carcinoma. TPS is an essential tool for anyone who is practicing urinary cytology, including cytotechnologists, pathologists-in-training and practicing pathologists. This book should find a place in every cytology laboratory throughout the world. The Concept has been endorsed by the American Society of Cytopathology, and the International Academy of Cytology.

Dr. Holzbeierlein has created an issue devoted to the current knowledge and best practice of Bladder Cancer and Upper Tract Urothelial Cell Carcinoma. Top expert authors have written clinical reviews on the following topics: Current Staging Strategies for Muscle Invasive Bladder Cancer and Upper Tract Urothelial Cell Carcinoma; Neoadjuvant Chemotherapy for MIBC and Upper Tract UCC; Bladder Preservation Therapy for MIBC; Pre-Operative and Intraoperative Optimization of the Cystectomy Patient; Robotic Cystectomy; Robotic Nephroureterectomy; Organ Sparing Cystectomy; Lymphadenectomy for MIBC and Upper Tract UCC; ERAS Pathways; Follow-up Management of Cystectomy Patients; Quality of Life after Cystectomy; Endoscopic Approaches to Upper Tract UCC; Adjuvant Therapy in MIBC and Upper Tract UCC; and Immunotherapy in MIBC and Upper Tract UCC. The urologist will have the clinical information he or she needs to treat these patients so as to optimize outcomes.

Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.

This book provides a comprehensive overview of contemporary evidence-based management of urothelial carcinoma. The first part of the book is devoted to urothelial carcinoma of the bladder and includes detailed description of the diagnosis and treatment of non-muscle-invasive, muscle-invasive, and advanced or metastatic disease. Attention then turns to upper tract urothelial carcinoma (UTUC), with individual chapters on diagnosis, nephron-sparing surgery, nephroureterectomy, and treatment of advanced or metastatic UTUC. The text is supported by many illustrations, photos, and tables that clarify management, and surgical video clips are also available to readers. The book will be a welcome addition to the literature as progress continues to be made in understanding the exact pathophysiology of urothelial carcinoma and in developing more effective diagnostic and therapeutic modalities. It will be useful both to researchers in the field of urothelial carcinoma and to clinicians, including especially residents and fellows.