Uses Of Inorganic Chemistry In Medicine

Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine. Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging. The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses. This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.

Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Transport and storage of metal ions in biology -- 5. Biominerals and biomineralization -- 6. Metals in medicine. -- Part B.: Metal ion containing biological systems : 1. Metal ion transport and storage -- 2. Hydrolytic chemistry -- 3. Electron transfer, respiration, and photosynthesis -- 4. Oxygen metabolism -- 5. Hydrogen, carbon, and sulfur metabolism -- 6. Metalloenzymes with radical intermediates -- 7. Metal ion receptors and signaling. -- Cell biology, biochemistry, and evolution: Tutorial I. -- Fundamentals of coordination chemistry: Tutorial II.

This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.

A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.

This book provides a contemporary research-led overview of the applications of inorganic materials in biomedicine. It begins with a short introduction summarising key concepts in inorganic materials (layered materials, framework materials etc.), and explaining the need for new materials in medicine. It then discusses the key areas in which inorganic materials have been applied, considering: drug delivery; imaging; diagnostics and theranostics; hard matter restoration; and vaccines. Each chapter gives an overview of the major extant challenges in the research area, before presenting a systematic review of how inorganic materials have been applied to gain traction in the field. A clear focus is maintained on the fate of the applied materials in vivo, clinical considerations, and the path to translation from lab to clinic. With contributions from leading researchers, Biomedical Applications of Inorganic Materials will provide a comprehensive introduction for advanced undergraduates, postgraduates and researchers wishing to learn about the topic.

Excerpt from d104-Book of Chemistry: Inorganic and Organic With Toxicology, for Students of Medicine, Pharmacy, Dentistry and Biology In the preface to the earlier editions of this book the author clearly specified its Scope and purpose. The general plan of the work remains unaltered, and may be indicated by the following extracts from the preface to the sixth edition. The main purpose of the section on inorganic chemistry is to supply certain data which shall serve as the text upon which to discuss the general principles of chemistry. It is the Opinion of the author that the object of chemical teaching should not be to lay up in the memory of the student a store of isolated facts, but rather to train his mind in those general principles by which he may reason out chemical problems for himself. If a teacher of chemistry to medical students aim merely to supply them with chemical facts, he and they are fore ordained to disappointment, but if the student be led to think in chemistry, ' the success and possible extent of the teaching, both in the fundamentals and in the superstructure of organic and physio logical chemistry, which can be attained, will be surprising and delightful to both instructor and pupil. And in this connection it must be said that the order of consideration of the several subjects which has been here followed, because it is logical, is not recommended in the teaching of students. The study should begin with that of a few elements and compounds, the consideration of the general physical and chemical principles being taken up as material for their discussion is supplied. The section on organic chemistry has been rearranged in the light of further information upon the relationship of substances, and somewhat extended, the prominence given to this branch of the subject the author believes to be justified, notwithstanding its intricacy and the impossibility of teaching it satisfactorily to those not well grounded in general chemistry, because of the intimate connection of organic chemistry with physiology and with modern pharmacy, and the impossibility of the comprehension of the problems of animal and pharmaceutical chemistry without the possession of an adequate knowledge of the principles of organic chemistry. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Excerpt from Text-Book of Chemistry: Inorganic and Organic With Toxicology, for Students of Medicine, Pharmacy, Dentistry and Biology In the preface to the earlier editions of this book the author clearly specified its scope and purpose. The general plan of the work remains unaltered, and may be indicated by the following extracts from the preface to the sixth edition. "The main purpose of the section on inorganic chemistry is to supply certain data which shall serve as the text upon which to discuss the general principles of chemistry. It is the opinion of the author that the object of chemical teaching should not be to lay up in the memory of the student a store of isolated facts, but rather to train his mind in those general principles by which he may reason out chemical problems for himself. If a teacher of chemistry to medical students aim merely to supply them with chemical facts, he and they are foreordained to disappointment, but if the student be led to 'think in chemistry,' the success and possible extent of the teaching, both in the fundamentals and in the superstructure of organic and physiological chemistry, which can be attained, will be surprising and delightful to both instructor and pupil. And in this connection it must be said that the order of consideration of the several subjects which has been here followed, because it is logical, is not recommended in the teaching of students. The study should begin with that of a few elements and compounds, the consideration of the general physical and chemical principles being taken up as material for their discussion is supplied. "The section on organic chemistry has been rearranged in the light of further information upon the relationship of substances, and somewhat extended, the prominence given to this branch of the subject the author believes to be justified, notwithstanding its intricacy and the impossibility of teaching it satisfactorily to those not well grounded in general chemistry, because of the intimate connection of organic chemistry with physiology and with modern pharmacy, and the impossibility of the comprehension of the problems of animal and pharmaceutical chemistry without the possession of an adequate knowledge of the principles of organic chemistry." About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.